Technologies

Surgeons transplant pig heart into human for first time

A medical milestone involving an animal’s genetically modified organ shines a hopeful light for the long ledger of patients awaiting organ transplants.

An ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time last week, marking a historic moment for medicine. As of Monday, three days after the surgery, the 57-year-old organ recipient, David Bennett, was reportedly still doing well.

While the team will monitor Bennett closely in coming weeks to ensure long-term benefits from the procedure, their medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis.

«There are simply not enough donor human hearts available to meet the long list of potential recipients,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the pig heart, said in a statement. He’s also a professor in transplant surgery at the medical school.

«We are proceeding cautiously,» Griffith added, «but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future.» According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant and more than 17 patients die each day before making their way to the top of the waitlist.

Leading up to his surgery, Bennett’s story unfortunately mimicked those of the many, many patients awaiting transplants. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, non-human-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

Technologies

Today’s NYT Strands Hints, Answers and Help for May 20, #443

Here are hints and answers for the NYT Strands puzzle No. 443 for May 20.

Looking for the most recent Strands answer? Click here for our daily Strands hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections and Connections: Sports Edition puzzles.

Today’s NYT Strands puzzle reminds me that I haven’t had a meal in a fancy restaurant in some time. Maybe it’s time to make a reservation. If you need hints and answers, read on.

I go into depth about the rules for Strands in this story.

If you’re looking for today’s Wordle, Connections and Mini Crossword answers, you can visit CNET’s NYT puzzle hints page.

Read more: NYT Connections Turns 1: These Are the 5 Toughest Puzzles So Far

Hint for today’s Strands puzzle

Today’s Strands theme is: Oh, of course!

If that doesn’t help you, here’s a clue: Elegant eats.

Clue words to unlock in-game hints

Your goal is to find hidden words that fit the puzzle’s theme. If you’re stuck, find any words you can. Every time you find three words of four letters or more, Strands will reveal one of the theme words. These are the words I used to get those hints but any words of four or more letters that you find will work:

SITE, FINE, SINE, DINE, PEAS, TEEN, PEER, STEEP, DEER, SEED, SEEN, POET, TREE, NOPE, SEES.

Answers for today’s Strands puzzle

These are the answers that tie into the theme. The goal of the puzzle is to find them all, including the spangram, a theme word that reaches from one side of the puzzle to the other. When you have all of them (I originally thought there were always eight but learned that the number can vary), every letter on the board will be used. Here are the nonspangram answers:

SOUP, SALAD, CHEESE, ENTREE, DESSERT, APPETIZERS

Today’s Strands spangram

Today’s Strands spangram is FINEDINING. To find it, start with the F that’s three letters down on the farthest row to the left, and wind across.

Toughest Strands puzzles

Here are some of the Strands topics I’ve found to be the toughest in recent weeks.

#1: Dated slang, Jan. 21. Maybe you didn’t even use this lingo when it was cool. Toughest word: PHAT.

#2: Thar she blows! Jan.15. I guess marine biologists might ace this one. Toughest word: BALEEN or RIGHT.

#3: Off the hook, Jan. 9. Similar to the Jan. 15 puzzle in that it helps to know a lot about sea creatures. Sorry, Charlie. Toughest word: BIGEYE or SKIPJACK

Technologies

Today’s NYT Connections Hints, Answers and Help for May 24, #713

Hints and answers for Connections for May 24, #713.

Looking for the most recent Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles.

Today’s Connections puzzle has a fun variety of categories. The purple one appeals to my English major heart. Read on for clues and today’s Connections answers.

The Times now has a Connections Bot, like the one for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. Players who are registered with the Times Games section can now nerd out by following their progress, including number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak.

Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time

Hints for today’s Connections groups

Here are four hints for the groupings in today’s Connections puzzle, ranked from the easiest yellow group, to the tough (and sometimes bizarre) purple group.

Yellow group hint: Goo-goo.

Green group hint: Not shirts.

Blue group hint: City that never sleeps.

Purple group hint: Acclaimed writers.

Answers for today’s Connections groups

Yellow group: Baby gear.

Green group: Kinds of pants minus «s.»

Blue group: New York sports team members.

Purple group: Black women authors.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections answers?

The yellow words in today’s Connections

The theme is baby gear. The four answers are bib, bottle, monitor and stroller.

The green words in today’s Connections

The theme is kinds of pants minus «s.» The four answers are capri, jean, jogger and slack.

The blue words in today’s Connections

The theme is New York sports team members. The four answers are Jet, Met, Net and Ranger.

The purple words in today’s Connections

The theme is black women authors. The four answers are Butler, Gay, Hooks and Walker.

Technologies

Today’s NYT Mini Crossword Answers for Tuesday, May 20

Here are the answers for The New York Times Mini Crossword for May 20.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Today’s NYT Mini Crossword is a fun one, and now I’m singing the song from 1-Across in my head. Need some help with today’s Mini Crossword? Read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

The Mini Crossword is just one of many games in the Times’ games collection. If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get at those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: «Pink ___ Club» (Chappell Roan hit)
Answer: PONY

5A clue: Instrument that might be made with a comb and wax paper
Answer: KAZOO

6A clue: How bedtime stories are often read
Answer: ALOUD

7A clue: On edge
Answer: TENSE

8A clue: Short Instagram video
Answer: REEL

Mini down clues and answers

1D clue: Less colorful
Answer: PALER

2D clue: Layer of the upper atmosphere
Answer: OZONE

3D clue: Totally pointless
Answer: NOUSE

4D clue: Hit a high note in a high place, perhaps
Answer: YODEL

5D clue: Kit ___ bar
Answer: KAT

How to play more Mini Crosswords

The New York Times Games section offers a large number of online games, but only some of them are free for all to play. You can play the current day’s Mini Crossword for free, but you’ll need a subscription to the Times Games section to play older puzzles from the archives.