Technologies

Doctors Transplant Genetically Modified Pig’s Heart Into Human in Medical First

The milestone operation shines a hopeful light for the long ledger of patients awaiting organ transplants.

Last month, an ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time, marking a historic moment for medicine. About five weeks post-surgery, the 57-year-old organ recipient, David Bennett, was still doing well.

«His heart function looks great, his blood pressure looks very good, and in fact, he’s on medicine to reduce his blood pressure. That’s how good it is right now,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the heart, said in an update on Feb 11.

On Feb. 14, medical staff caring for Bennett even released an inspiring clip of him watching this year’s Super Bowl and singing «America the Beautiful» as Jhené Aiko performed her rendition at the game. While the team continues to monitor Bennett closely, particularly due to reported preoperative kidney setbacks that persisted after the procedure, Griffith offered encouraging words: «Beyond that, I’d say all thumbs are up.»

This medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis. «There are simply not enough donor human hearts available to meet the long list of potential recipients,» Griffith, who’s also a professor in transplant surgery at the university, said in a statement.

«We are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,» Griffith said. According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant, and more than 17 patients die each day while still on the waitlist.

Leading up to his surgery, Bennett was one of those anxious patients on hold. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, nonhuman-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

«We’ve been asked how we would define success,» Griffith said in the team’s most recent update, underlining his cautious hope. «I think we’ve surpassed, in many measures, what we expected.»

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for April 16, #570

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for April 16 No. 570.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition is a fun one, especially if you enjoy unusual team names. If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Put your glasses on for this.

Green group hint: Hoops home.

Blue group hint: The minors.

Purple group hint: Hidden hoops word.

Answers for today’s Connections: Sports Edition groups

Yellow group: Look at.

Green group: Seen at an NBA court.

Blue group: Double-A baseball teams.

Purple group: Starts with a WNBA team.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is look at. The four answers are observe, spectate, view and watch.

The green words in today’s Connections

The theme is seen at an NBA court. The four answers are benches, half-court logo, scorer’s table and shot clock.

The blue words in today’s Connections

The theme is double-A baseball teams. The four answers are Biscuits, Drillers, Trash Pandas and Wind Surge.

The purple words in today’s Connections

The theme is starts with a WNBA team. The four answers are dreamy, firefly, Skype and sundial.

Technologies

Today’s NYT Mini Crossword Answers for Thursday, April 16

Here are the answers for The New York Times Mini Crossword for April 16.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Need some help with today’s Mini Crossword? It’s pretty simple, but 1-Across is a bit tricky. Read on for all the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: Bow ties and ribbons that you can’t wear?
Answer: PASTA

6A clue: Opposite of lower
Answer: UPPER

7A clue: Flappable origami creation
Answer: CRANE

8A clue: Where the Hangul alphabet is used
Answer: KOREA

9A clue: Apparatus under a trapeze
Answer: NET

Mini down clues and answers

1D clue: Disc dropped on center ice
Answer: PUCK

2D clue: One might read «Kiss the Chef»
Answer: APRON

3D clue: Unlikely outcome after a 7-10 split
Answer: SPARE

4D clue: Fundamental belief
Answer: TENET

5D clue: Bay ___ (part of California)
Answer: AREA

Technologies

Apple Reportedly Plans to Send Siri Engineers to AI Coding Bootcamp

The move comes just weeks before the company is expected to unveil a new Siri.

Apple plans to send dozens of Siri engineers to a multiweek AI coding bootcamp, The Information reported Wednesday. The move comes less than two months before the company is widely expected to unveil a new Siri experience as part of a broader AI reboot.

A group of fewer than 200 engineers will be sent to the bootcamp, leaving approximately 60 members of the core Siri development team behind to continue working on Siri, while another 60 will evaluate Siri’s performance, according to The Information. The outlet also reported that AI has grown in popularity in some Apple divisions, prompting some teams within the company to allocate large parts of their budgets to Claude Code.

Apple representatives didn’t immediately respond to a request for comment.

Siri, once a pioneer, has lagged behind its rivals in voice assistants. Apple had planned to roll out a smarter, AI-driven Siri in 2025 as part of its Apple Intelligence initiative, but executives delayed the launch until spring 2026, admitting the early version wasn’t reliable enough to ship.

For Apple, the move would mark another attempt to reset expectations around its AI strategy after repeated delays to its more advanced Siri ambitions. The news also comes as John Giannandrea, Apple’s former AI chief, is reportedly leaving the company this week after stepping down from that role in December.

The new Siri experience is expected to be introduced at Apple’s Worldwide Developers Conference on June 8 and would arrive as part of iOS 27, iPadOS 27 and MacOS 27 later this year, according to a Bloomberg report in March. The report says Apple is testing out a new Siri that would make the assistant feel more like a standalone AI chatbot — think ChatGPT or Claude — rather than the current built-in tool.