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Moderna booster FAQ: COVID shot side effects, vaccine effectiveness, what to know about third dose

A COVID-19 booster shot is a critical piece in the fight against the omicron variant.

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

A third of of the US is now boosted with a third dose of the Moderna or Pfizer COVID-19 vaccine or a second of Johnson & Johnson’s. All three boosters shots are effective in protecting against hospitalization and death, even from the highly contagious omicron variant. Research released by the UK on Friday continues to underscore the importance of boosters. The UK Health Security Agency’s report notes that 20 weeks after the second dose of mRNA vaccines, protection against the omicron variant decreases to only 10%, with a booster, or third dose, bringing protection back up to 90%.

The UK report also strengthened the case for the Moderna booster, noting that protection against omicron was higher in those who received a Moderna booster after two Pfizer shots compared with those who received a third Pfizer shot. The Moderna booster was also slightly more effective than Pfizer for people who received two doses of the AstraZeneca vaccine.

The Centers for Disease Control and Prevention recommends everyone 16 years and older get a booster six months after their second dose of Moderna or Pfizer. The CDC also recommends a booster for adolescents 12 and up who have a weakened immune system, are undergoing cancer treatment or have certain other health conditions.

Countries such as Germany, Israel and the UK are weighing a possible fourth booster, and Dr. Anthony Fauci, chief medical adviser to President Joe Biden, said a fourth jab was “conceivable” in the US, too.

“It is conceivable that in the future we might need an additional shot, but right now, we are hoping that we will get a greater degree of durability of protection from that booster shot,” Fauci said at a White House briefing Wednesday. “So we’re going to take one step at a time, get the data from the third boost and then make decisions based on scientific data.”

So far, the vaccines have proven highly effective in preventing serious reactions and death from COVID-19. People who are unvaccinated are 10 times more likely to be hospitalized if infected. With a federal vaccine mandate slated to start next month, the Biden administration expects even more Americans to get the jab.

Here’s what you need to know about the Moderna booster, including doses, side effects and how to get a free ride to your vaccination appointment. For even more details, here’s the latest on COVID-19 vaccines for kids, how you can soon get a free COVID-19 test kit and what to know about breakthrough infections.

How effective is the Moderna booster against the omicron variant?

On Dec. 20, Moderna President Stephen Hoge said early results demonstrated the company’s COVID-19vaccine booster increased “omicron-neutralizing antibodies” approximately 37-fold. Forcomparison, earlier this month Pfizer said its booster raises antibody levels 25-fold, offering “a sufficientlevel of protection” against omicron.

Early studies of omicron variant infections in the US support the idea that current vaccines offer weaker protection against the newest strain, especially for individuals who did not get a booster yet.

Dr. Rochelle P. Walensky, CDC director, said Dec. 10 that of the 43 earliest cases attributed to the omicron variant, 34 people had been fully vaccinated, though only 14 of those patients had also received a booster. And five of the people who were boosted were infected less than 14 days after the third shot — thus, before full protection kicks in.

What are the possible side effects with the Moderna booster?

Modernasays possible side effects for its booster shot are similar to thosefrom the two primary doses and include pain or swelling at theinjection site, as well as fatigue, muscle pain, headache, fever, chillsand nausea.

The drugmaker said there is “a remote chance” that its COVID‑19 vaccine could cause a severe allergic reaction.

The good news is, according to the CDC, those whogot the Moderna booster dose reported far fewer reactions than they didafter the second dose of the vaccine.

Will we need an annual COVID booster shot?

With vaccinesappearing to offer waning protectionand the continuing evolution ofvariants, Hoge said we will most likely needseasonal COVID boosters,much like we do with the flu, at least toprotect those at high risk ofinfection.

The CDC updated its guidanceto indicate that, starting in 2022, some immunocompromised people will be able to get afourth COVID-19 booster shot.

Is Moderna working on additional COVID vaccine boosters?

Hoge said the company’s current 50-microgram COVID booster gives “quite respectable” protection. The company is continuing to study an omicron-specific vaccine and a multivalent one that could protect against other variants, including the alpha and delta strains, in case either is needed.

The company also said a 100-microgram version of its current vaccine, Spikevax, appears to raise antibody protection 83-fold. Hoge said Moderna could have new versions of its vaccine ready early in 2022, but is not yet planning to ask the CDC and US Food and Drug Administration to amend its booster authorization for the 100-microgram trial version of Spikevax.

When can I get a COVID-19 vaccine booster shot?

If you got a Moderna or Pfizer jab, you’re eligible for a booster six months after the date of the second shot listed on yourvaccination card. If you got the one-shot Johnson & Johnson vaccine, you’ll want a booster two months later (more below).

The CDC and other health authorities are now urging people to get boosters as soon as they’re eligible, to keep the immune response againstomicron, delta and other coronavirus variants of concern as strong as possible.

On Dec. 2, Biden outlined a plan forMedicare to contact the 64 million people it serves and for AARP toreach out to its 38 million members about getting a booster shot. And nationwide pharmacy chains like Walgreens,CVS and Rite Aid are contacting customers who got a vaccine attheir stores when it’s time to schedule a booster.

Some countries, including Germany and South Korea, have reduced the waiting time for booster shots to 3 months. In August, President Biden discussed the possibility of reducing the waiting period for booster shots, but no explicit action has been taken by US officials yet.

Should people who are pregnant get a booster shot?

The COVID-19 booster recommendations apply to all people 18 years and older, including those who are pregnant. The CDC urges pregnant people to get a COVID-19 vaccine, and a booster is half a full vaccine dose.

“People who are pregnant or recently pregnant are more likely to get severely ill with COVID-19 compared with people who are not pregnant,” the CDC website says.

While there is no evidence that getting vaccinated decreases fertility in women or men, a recent study linked COVID-19 infection in pregnant women to a higher risk of stillbirth.

Is the Moderna booster shot a third dose of the vaccine?

The Moderna booster is a half dose of the same vaccine used in its first two full shots. The goal is to top up the formula and reinforce the body’s immune response against the virus and its variants. While the first two shots of the Moderna vaccine were each 100 micrograms, the booster is a 50-microgram dose.

Moderna said a 100-microgram version of its current vaccine, Spikevax, appears to raise antibody protection 83-fold but it is not yet planning to ask the CDC or FDA to approve the more potent booster.

Moderna is also working on a combination shot that contains this year’s flu vaccine and its COVID-19 booster vaccine, but that’s not available right now.

How do I know which pharmacies have Moderna booster shots available?

Boosters are available at roughly 80,000 locations across the US, including over 40,000 pharmacies. Some 90% of Americans have a vaccine site within five miles of where they live.

A free service backed by the CDC sends you information on vaccine sites when you text your ZIP code to this number: 438829. The response will show you COVID-19 vaccine locations in your area, along with the brands they carry for certain age groups, for instance, Moderna 18+. This can save you from having to call around, or show up to an appointment to find that your booster of choice isn’t available. The text message also offers a shortcut to make your appointment right from your phone screen.

In addition, you can check Vaccines.gov to see which vaccines are available where, or call 800-232-0233 for additional vaccine information.

How can I get a free ride to get my booster shot?

Lyft and Uber are offering free rides for some people who need them. An easy way to access those links for more information is through the text feature above. You can also go to Lyft.com/vax or call Uber at 855-921-0033.

Who can get a Moderna booster shot right now?

On Nov. 19, all US adults 18 and older became eligible to receive COVID-19 booster shots if it’s been at least six months since they’ve received a second dose of either the Moderna or Pfizer vaccine. Those who received the Johnson & Johnson vaccine are eligible for a booster dose after two months.

Adults are encouraged to get whatever booster dose is available, even if that means mixing and matching vaccine boosters (more below). The CDC’s recommendation of mRNA vaccines — Moderna or Pfizer — also applies to booster shots.

Is it safe to mix and match vaccine and booster brands?

Yes. The FDA has authorized mixing COVID-19 boosters, which in the US means Moderna and Pfizer. Any adult eligible for a booster can get any of the available brands of coronavirus vaccines. If you initially received Johnson & Johnson and it’s been two months or longer since you received the initial dose, you’ll be able to get the Moderna or Pfizer booster. If you received Moderna or Pfizer for your first two shots, you could pick any authorized vaccine available to you, if you qualify and it’s been six months or longer since your second shot.

In its study, the CDC found 95% of those who got Moderna for the first round of vaccine shots chose Moderna for the booster dose.

Is the Moderna COVID-19 booster shot still free?

All booster shots will be free, regardless of immigration or health insurance status. However, depending on where you get your booster shot — for example, at a local pharmacy — you may be asked to provide your insurance card information, including your name, date of birth and membership number. But you will not be charged for your COVID-19 vaccine or booster shot.

What does the Moderna booster shot do?

As the vaccine’s effectiveness decreases over time, a COVID-19 booster shot — whether from Moderna, Pfizer or Johnson & Johnson — recharges your body’s immune response and guards against a breakthrough infection.

Recent studies of the Pfizer and AstraZeneca vaccines show that their effectiveness can begin to wane after six months. Moderna said early data suggests that those who received the Moderna vaccine in 2020 are showing a higher rate of breakthrough COVID-19 infections than those vaccinated this year, suggesting the need for a booster to maintain high levels of protection.

For more on coronavirus treatments and vaccines, here’s what we know about monoclonal antibody treatments, the new federal vaccine mandates and why some people may not want the shot.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

OpenAI boss Sam Altman spells out how and why the AI industry wants to slow down: ‘We could lose control’

OpenAI’s chief has made comments detailing how AI safety frameworks and a slowdown could work, as the industry unites behind concerns.

OpenAI chief Sam Altman has made his most detailed comments yet on how artificial intelligence safety frameworks could work, after he joined Anthropic’s Dario Amodei and Elon Musk in calling for an industry slowdown over the weekend.

Safety concerns over the technology have hit fever pitch since an Anthropic researcher quit last week, warning that those building it believed that it could “kill us all by the end of the decade” and prompting other employees at the lab and rival OpenAI to warn of catastrophic risks.

AI bosses have since shown a rare display of unity, with both Altman and Musk on Saturday backing an essay from Amodei that urged AI companies to slow how quickly they improve their most advanced models.

AI stocks were down Monday as investors digested the comments. U.S. President Donald Trump dismissed the CEOs’ warning on Sunday, saying a slowdown was not needed and would jeopardize America’s lead in AI over China.

Sam Altman sets out 2 ways AI could go ‘very badly’

“We welcome a federal framework that sets consistent safety requirements for frontier AI,” Altman said in a post on X just after midnight on Monday, adding that “no amount of American competitive pressure should justify recklessness.”

Altman warned of two ways AI progress could go “very badly,” including losing “control of the future to AI” and too much power concentrating around a single person or company.

Meanwhile, lawmakers in Washington are scrambling to address calls for safeguards.

This all comes as Anthropic and OpenAI gear up for what’s expected to be historic initial public offerings. Altman ruled out going public in 2026 in an interview with Fortune published Saturday.

Amodei’s three-step proposal

Many AI safety fears revolve around models developing the ability to improve their own performance, a technique known as recursive self-improvement, or RSI.

“Since roughly this summer, AI has been advancing drastically faster, driven primarily by AI’s growing ability to build the next generation of AI,” said Amodei in his essay. “Left unchecked, it could outrun our ability to understand and control these systems, and so must be pursued very carefully, if at all.”

Amodei proposed a three-step plan aimed at tempering the pace of development without “sacrificing commercial advantage or the United States’ lead in AI.”

The plan involves each frontier AI company giving “employee-like access” to external evaluators — which he said Anthropic was committing to now. Amodei also called for frontier AI labs to establish common safety standards, limit the rate of unchecked AI progress and attempt to coordinate efforts globally.

On Saturday, Altman said in a brief X post he agreed with Amodei that AI companies should “pace the frontier.” He added that “committing to having independent evaluators with employee-like access is a great idea, and we will do the same.”

“Consistent rules to manage frontier risk so that we can maximize the benefits are a good idea (and we are excited by ideas like independent auditors),” Altman said in his Monday post. But, he added, “When we talk about ‘pacing,’ we do not mean ‘stopping.’ Progress has been rapid and will continue to be.”

“Pacing will be well worth this cost; no amount of American competitive pressure should justify recklessness, or let capabilities get ahead of alignment and monitoring,” he concluded.

“Where we will need the help of our government is for international coordination. But first we should do what we can ourselves.”

International cooperation

Coordinating AI safety measures and an industry slowdown with rival AI developers in China will likely pose big challenges.

The U.S. and China remain locked in a battle for AI supremacy, with tensions ratcheting up as Chinese models have become more advanced and their global adoption grows.

Amodei said Sunday that the “toughest dilemma” about his proposal is what happens if adversarial nations choose not to do the same.

“The more long-term thing would be working together to put a speed limit on the rate of AI progress,” Amodei told CBS News’ “Sunday Morning.”

“I think that’s going to be very difficult because the incentives to pull ahead and the military advantage that you get from that are so large. And honestly, I don’t know if it’s possible, but we should try.”

The Anthropic CEO’s essay has drawn criticism in China, with the state-owned Global Times writing on Monday that “Amodei’s proposals seek to portray China’s legitimate development in AI as a threat and further fuel confrontation between China and the US in the field.”

China’s Foreign Ministry said on Monday that the CEOs’ comments were “fearmongering.”

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Novo CEO tells CNBC why drugmaker is rebranding, needs to ‘rethink’ obesity strategy

The Danish drugmaker called the changes the beginning of a new chapter for the company, which faces stiff competition from Eli Lilly.

Novo Nordisk

The Danish drugmaker called the changes the beginning of a new chapter, as it has been grappling with stiff competition from chief rival Eli Lilly

In an exclusive interview with CNBC, Novo CEO Mike Doustdar said the rebrand and culture shift are “part of the same package” for the company to evolve its strategy as it tries to win back customers from Lilly.

“I think there’s no secret that over the last four or five years, the external environment and what has happened to Novo Nordisk has really made us reflect how we need to readjust and rethink about the next decade to come and what shifts are needed in our strategic direction,” he told CNBC.

Doustdar said the “work is cut out for us,” adding that Novo needs to improve several aspects – from research and development and manufacturing to sales and marketing – to be able to compete in the obesity drug market.

Shares of Novo have dropped about 15% this year despite the successful launch of the oral version of Wegovy, which surpassed 3 million prescriptions as of June. The company recently scrapped three trials on an experimental cardiovascular drug. That challenge came as it continues to lag in the obesity space with 38.8% market share compared to Lilly’s 60.9% in the second quarter, according to a Lilly earnings presentation citing IQVIA data.

In a release, Novo also announced a broader company rebrand focused around the phrase “Lasting Health Starts Now,” which promotes the idea that patients should make progress toward long-term well-being immediately rather than later. The company said the marketing is a bid to build relevance and trust with the public and other stakeholders, and bring “breakthrough science closer to people’s daily lives.”

When asked whether the rebrand and cultural overhaul were driven by Novo’s recent market share losses in obesity, Doustdar said the changes were less about competitive setbacks and more about adapting to a dramatically different operating environment.

He said the rapid growth of obesity treatments has transformed Novo’s patient base and shifted the market toward a more consumer-oriented model, where patients move on and off therapies more frequently than in traditional diabetes care. As a result, Doustdar said Novo needs to become more focused on meeting patients where they are, while increasing the speed and clarity of its decision-making to keep pace with the evolving market.

“Our operating environment phenomenally changed compared to just 10 years ago,” he told CNBC.

Novo Nordisk will remain the legal name for the company, according to the release. That original name dates back to the 1989 merger of two competing Danish pharmaceutical companies: Novo Terapeutisk Laboratorium and Nordisk Insulinlaboratorium.

The drugmaker said its corporate culture will be based on a new set of four principles that will help it gain advantages in an increasingly competitive market where more of its products have gone direct-to-consumer.

Those tenets are innovating with patients as the primary focus, raising the company’s performance to “create greater value for all stakeholders,” setting clearer priorities and simpler workflows and never compromising on patient safety and ethics.

“When you think about strategy, that’s really the the journey you’re taking and the direction you’re setting the company to go forward with,” Doustdar said. “But you also need behaviors. You need a cultural element that allows your colleagues and yourself to really make sure that a strategy gets executed.”

Despite its challenges, Novo has had one significant tailwind this year in the launch of the oral version of Wegovy. On top of its explosive launch, the pill had a head start over a rival weight loss pill from Lilly called Foundayo.

Doustdar said Novo has maintained “a lion’s share” of the oral market even with competition, noting that physicians find the Wegovy pill to be more effective than Lilly’s, with around 17% of weight loss.

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Iran says it destroyed U.S. advanced drone over Hormuz as Middle East conflict intensifies

Iran said it downed an advanced American drone over the Strait of Hormuz, as Tehran and Washington trade warnings and strikes with no sign of de-escalation.

Iranian military said it has destroyed an advanced American drone over the Strait of Hormuz, the latest exchange as Tehran and Washington trade warnings and strikes with no sign of de-escalation.

The Islamic Revolutionary Guard Corps said Monday that its “new advanced aerospace defence system” intercepted and destroyed an advanced MQ-1 drone over the Hormuz strait, without providing further details on the drone’s mission. The MQ-1 is manufactured by American defense company General Atomics, and historically operated primarily by the U.S. Air Force and the CIA.

The incident followed a series of Iranian operations against U.S. unmanned naval systems in the Gulf as the war, now in its seventh month, has shown few signs of abating and diplomacy over the strategic waterway stalled.

On Sunday, President Donald Trump said the U.S. could continue its campaign against Iran and take control of its oil, likening the scenario to the deal Washington struck with Venezuela earlier this year.

“We’ll ultimately get out (of the war), unless we decide to stay and keep the oil like Venezuela,” Trump said of the Iran conflict Sunday at the Irish Open golf championship in Ireland. He added that U.S. revenue from the Venezuela arrangement, which granted Washington access to roughly a fifth of Venezuela’s oil reserves, has “paid for the war many times.”

Under the agreement reached in August, Venezuela ceded majority U.S. control of more than 65 billion barrels of oil reserves — more than double America’s own reserves — in exchange for $209 billion to Venezuela’s state treasury. Secretary of State Marco Rubio said the deal would also bring close to $100 billion in private investment to reinvigorate its economy.

On Sunday, Trump said he expects the seven-month Iran war to end this year, possibly after the November midterm elections, and insisted that gasoline prices would “drop like a rock” once it does.

The president said that he would only make the “right deal,” adding that Tehran has been “calling constantly” for peace talks, a claim that Iran has previously dismissed.

Stalled Hormuz talks

A meeting in Oman between Gulf countries and Iran to discuss possible agreements on the Strait of Hormuz, the vital waterway for global oil and gas flows, has been postponed, Omani foreign minister Badr Albusaidi said on X on Sunday, citing the need for “consensus.”

Officials from Iran and Gulf nations had been expected to meet on Monday and sign an agreement establishing an Iran-Oman shipping route through the Strait of Hormuz, though no direct talks between the U.S. and Iran were ongoing.

The Strait of Hormuz has been subjected to an Iranian and later U.S. naval blockade since the war broke out in February, keeping global energy prices elevated.

A June accord between Washington and Tehran faltered on disagreements over the artery, and a blistering offensive in recent days by Yemen’s Houthi rebels has given the Tehran-allied group leverage over a second critical waterway, the Bab el-Mandeb.

Ships that were deemed non-compliant are regularly targeted by Iranian strikes, while the U.S. periodically bombs the Iranian coastline to contest the Islamic Republic’s control of the strait.

Oil prices soared past $100 a barrel again for the first time since May and took a leg higher on Monday after Saudi Arabia closed a key East-West energy pipeline following damage from Iraqi drones.

U.S. West Texas Intermediate futures were up 2.3% to $102.39 per barrel. Brent crude, the international benchmark, traded 2.4% higher to $107.11 a barrel.

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