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Moderna booster update: How well and how long does it protect against omicron?

New research shows that the Moderna COVID-19 vaccine booster can defend against the omicron variant. But for how long?

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

New research demonstrates that mRNA boosters — like Moderna’s and Pfizer’s — offer significant protection against the new omicron variant of COVID-19. However, data from the UK on Friday indicates that booster effectiveness starts to decrease notably after 10 weeks. And as countries like Germany and South Korea have shortened the wait time for booster shots, US experts are considering a similar approach.

In a technical briefing released Friday, the UK Health Security Agency announced that the Oxford/AstraZeneca, Pfizer/BioNTech and Moderna vaccines all protect against omicron less than they did against delta and that protection from boosters wanes in time. Booster effectiveness generally decreased from 60% to 70% protection at two to four weeks after the shot, down to 35% to 45% at 10 weeks, depending on the combination of vaccines administered.

The UK report also adds weight to the hope that omicron infections are less severe than with the delta variant, noting that the risk of hospitalization from omicron is about three-fifths of that from delta.

On ABC’s This Week on Sunday, Dr. Ashish Jha, dean of the Brown University School of Public Health, discussed the possibility of shortening the wait time for boosters. He noted, «The data suggests both from Moderna and Pfizer vaccines that shortening it to as little as three months, but probably more in the sort of four to five months range, because we do see a waning of the immunity of the antibodies by four to five months.»

In a report published Wednesday on the preprint site Medrxiv, scientists at Copenhagen’s Statens Serum Institut examined health records of 3 million Danes taken between Nov. 20 and Dec. 12. They found vaccine effectiveness among seniors 60 and older who had received a booster dose 14 to 44 days earlier averaged 54.6%, according to Reuters. (That’s comparable to the rate found shortly after receiving one shot of the Pfizer vaccine, which quickly wanes.)

Their research hasn’t been peer-reviewed yet, but it follows preliminary data from last week indicating Moderna’s half-dose COVID booster shot can raise antibody levels against omicron 37 fold. Moderna President Stephen Hoge said during a conference call that the lab results were «reassuring» and put booster recipients «comfortably» above the level of a breakthrough risk.

Moderna also indicated a potential double dose of the booster, 100 micrograms versus 50 micrograms, would increase omicron-neutralizing antibodies «approximately 83-fold higher than pre-boost levels.»

Omicron has quickly become the dominant strain in the US, accounting for nearly 75% of new COVID-19 cases. While it appears able to evade some of the defenses offered by two doses of the Pfizer and Moderna vaccines, boosters offer some protection against infection and are highly effective in preventing serious illness.

«The good news is when you boost someone, [protection] goes right back up,» Dr. Anthony Fauci, chief medical adviser to President Joe Biden, said on CNN last week.

On Dec. 16, a CDC advisory committee recommended Moderna’s Spikevax and Pfizer-BioNTECH’s Comirnaty, both mRNA vaccines, over Johnson & Johnson’s one-jab carrier, or virus vector, vaccine.

According to Our World in Data, the US averaged about 840,000 booster shots per day for the week ending Dec. 17, and more than 64 million Americans have been boosted since Aug. 13. The increased focus on boosters comes as the omicron variant forces the CDC, health officials and organizations to reconsider what it means to be «fully vaccinated.» President Biden recently announced new plans — including «free» at-home COVID-19 test kits and stricter rules for international travelers — to protect Americans from the surging omicron variant.

The CDC urges anyone 18 years or older to get a booster six months after their second dose of Moderna or Pfizer (and anyone 16 or 17 years old to get a booster six months after their second dose of Pfizer).

So far, the vaccines have proven highly effective in preventing serious reactions and death from COVID-19. People who are unvaccinated are 10 times more likely to be hospitalized if infected. With the federal vaccine mandate expected to start next month, the Biden administration expects even more Americans to get the jab. The government has also ordered 13 million courses of antiviral drugs in anticipation of higher caseloads this winter.

Here’s what you need to know about the Moderna booster, including doses, side effects and how to get a free ride. to your vaccination appointment. For even more details, here’s the latest on COVID-19 vaccines for kids, how you can soon get a free COVID-19 test kit and what to know about breakthrough infections.

How effective is the Moderna booster against the omicron variant?

On Monday, Moderna’s Hoge said early lab research shows the pharmaceutical company’s COVID-19vaccine booster provides «good protection against the omicronvariant» by raising antibody levels approximately 37 fold. Forcomparison, Pfizer said earlier this month its booster raises antibody levels 25 fold,creating «robust protection» and offering «a sufficientlevel of protection» against omicron.

Studies of omicron variant infections in the US appear to support the concern about weakened protection for those who are fully vaccinated with two doses of the Moderna and Pfizer vaccines or one of Johnson & Johnson’s, but did not get a booster yet. Dr. Rochelle P. Walensky, CDC director, said Dec. 10 that80% of the first confirmed US cases with the mutated strain had been in patients who were fullyvaccinated.

Is Moderna working on additional COVID vaccine boosters?

On Monday, Moderna president Stephen Hoge said the company’s current 50-microgram COVID booster gives «quite respectable» protection. The company is continuing to study an omicron-specific vaccine and a multivalent one that could protect against other variants, including the alpha and delta strains, in case either is needed.

The company said it is also studying a 100-microgram version of its current vaccine booster, which appears to raise antibody protection 83 fold. Hoge said Moderna could have new versions of its vaccine ready early in 2022 but is not planning to ask the CDC and FDA to amend its booster authorization for the 100-microgram trial version of its booster.

Will we need an annual COVID booster shot?

With vaccines appearing to offer waning protectionand a continuing evolution of COVID variants, Hoge said we will most likely needseasonal boosters, much like we do with the flu, at least toprotect those at high risk of infection. The new research from UKHSA strongly indicates reduced protection from vaccine boosters after 10 weeks.

The CDC updated its guidanceto indicate that, starting in 2022, some immunocompromised people will be able to get afourth COVID-19 booster shot.

When is it time to get a COVID-19 vaccine booster shot?

If you got Moderna or Pfizer jab, you’re eligible for a booster six months after the date of the second shot listed on yourvaccination card. Two months after the Johnson & Johnson vaccine is the time for a booster (more below).

The CDC and other health authorities are now urging people to get boosters as soon as they’re eligible, to keep the immune response againstomicron, delta and other coronavirus variants of concern as strong as possible.

On Dec. 2, President Biden outlined a plan forMedicare to contact the 64 million people it serves and for AARP toreach out to its 38 million members about getting a booster shot. Pharmacies like Walgreens,CVS and Rite Aid are contacting customers who got a vaccine attheir stores when it’s time to schedule a booster.

Should people who are pregnant get a booster shot?

The COVID-19 booster recommendations apply to all people 18 years and older, including those who are pregnant. The CDC urges pregnant people to get a COVID-19 vaccine, a booster is half a full vaccine dose.

«People who are pregnant or recently pregnant are more likely to get severely ill with COVID-19 compared with people who are not pregnant,» the CDC says on its website.

While there is no evidence that getting vaccinated decreases fertility in women or men, a recent study also linked COVID-19 infection in pregnant people to a higher risk of stillbirth.

Is the Moderna booster shot a third dose of the vaccine?

Booster shots of COVID-19 vaccines are currently half doses of the same vaccine used in the first two full shots. The goal is to top up the formula and reinforce the body’s immune response against the virus and its variants. While the first two shots of the Moderna vaccine were each 100 micrograms, the booster is a 50-microgram dose.

Moderna is also working on a combination shot that contains this year’s flu vaccine and its COVID-19 booster vaccine, but that’s not available right now.

How do I know which pharmacies have Moderna booster shots available?

Boosters are available at roughly 80,000 locations across the US, including over 40,000 pharmacies. Some 90% of Americans have a vaccine site within five miles of where they live.

A free service backed by the CDC sends you information on vaccine sites when you text your ZIP code to this number: 438829. The response will show you COVID-19 vaccine locations in your area, along with the brands they carry for certain age groups, for instance, Moderna 18+. This can save you from having to call around, or show up to an appointment to find that your booster of choice isn’t available. The text message also offers a shortcut to make your appointment right from your phone screen.

In addition, you can check Vaccines.gov to see which vaccines are available where, or call 800-232-0233 for additional vaccine information.

How can I get a free ride to get my booster shot?

Lyft and Uber are offering free rides for some people who need them. An easy way to access those links for more information is through the text feature above. You can also go to Lyft.com/vax or call Uber at 855-921-0033.

Who can get a Moderna booster shot right now?

On Nov. 19, all US adults 18 and older became eligible to receive COVID-19 booster shots if it’s been at least six months since they’ve received a second dose of either the Moderna or Pfizer vaccine. Those who received the Johnson & Johnson vaccine are eligible for a booster dose after two months. Adults are encouraged to get whatever booster dose is available, even if that means mixing and matching vaccine boosters (more below).

What are the side effects of Moderna’s booster?

Moderna says possible side effects for its booster shot are similar to those from the two primary doses, and include pain or swelling at the injection site, as well as fatigue, muscle pain, headache, fever, chills and nausea.

The good news is, according to the CDC, those who got the Moderna booster dose reported far fewer reactions than they did after the second dose of the vaccine.

Is it safe to mix and match vaccine and booster brands?

Yes. The US Food and Drug Administration has authorized mixing COVID-19 boosters, which in the US means Moderna and Pfizer. Any adult eligible for a booster can get any of the available brands of coronavirus vaccines. If you initially received Johnson & Johnson and it’s been two months or longer since you received the initial dose, you’ll be able to get the Moderna or Pfizer booster. If you received Moderna or Pfizer for your first two shots, you could pick any authorized vaccine available to you, if you qualify and it’s been six months or longer since your second shot.

In its study, the CDC found 95% of those who got Moderna for the first round of vaccine shots chose Moderna for the booster dose.

Is the Moderna COVID-19 booster shot still free?

All booster shots will be free, regardless of immigration or health insurance status. However, depending on where you get your booster shot — for example, at a local pharmacy — you may be asked to provide your insurance card information, including your name, date of birth and membership number. But ou will not be charged for your COVID-19 vaccine or booster shot.

What does the Moderna booster shot do?

As the vaccine’s effectiveness decreases over time, a COVID-19 booster shot — whether from Moderna, Pfizer or Johnson & Johnson — recharges your body’s immune response and guards against a breakthrough infection.

Recent studies of the Pfizer and AstraZeneca vaccines show that their effectiveness can begin to wane after six months. Moderna said early data suggests that those who received the Moderna vaccine in 2020 are showing a higher rate of breakthrough COVID-19 infections than those vaccinated this year, suggesting the need for a booster to maintain high levels of protection.

For more on coronavirus treatments and vaccines, here’s what we know about monoclonal antibody treatments, the new federal vaccine mandates and why some people may not want the shot.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

Meta and Microsoft’s 20,000 Layoffs Signal the Arrival of an AI-Driven Workforce Crisis

Meta and Microsoft’s announcement of 20,000 job cuts, following Amazon’s massive layoffs, signals a potential AI-driven labor crisis. Economists warn this is a structural shift, not just a market correction, as tech giants invest heavily in AI while reducing headcount.

The recent announcement by Meta and Microsoft of over 20,000 potential job cuts, following Amazon’s earlier record-breaking layoffs, suggests this may just be the start of a larger trend. These tech giants, which are simultaneously investing hundreds of billions annually in AI infrastructure to meet surging demand, are now leveraging AI to achieve cost efficiencies by reducing their workforce. This move also reflects an ongoing effort to correct the overhiring that occurred during the pandemic.
Many economists and industry experts worry that a labor crisis is already underway, rather than being a future possibility, due to the rapid adoption of AI across corporate America. According to Layoffs.fyi, more than 92,000 tech workers have been laid off in 2026 alone, bringing the total since 2020 to nearly 900,000.
«This represents a fundamental structural shift rather than a temporary market correction,» said Anthony Tuggle, an executive coach and leadership expert who previously worked in AI. «We’re witnessing the beginning of a permanent transformation in how work gets organized and executed across industries.»
Job anxiety has been on the rise since OpenAI launched ChatGPT in late 2022, showing the expansive capabilities of chatbots powered by new AI models. Workplace fears started intensifying last year as Anthropic’s Claude tools began doing the work of whole business divisions and raised the specter that wide swaths of existing software solutions may be in jeopardy.
Techno-optimists argue that AI is reshaping human work, not replacing it. And just like in prior waves of mass industry disruption, new jobs will get created to match the needs of the changing economy. Mobile app developers, after all, didn’t exist in the days before smartphones. And what use were IT administrators before we created servers?
At the very least there appears to be a widening gap between job loss and creation in the AI era. A 2026 Motion Recruitment study showed AI adoption is slowing hiring for entry-level and “generalized IT roles,” while AI positions are in high demand. Tech salaries remain largely flat from 2025 with the exception of some specialized jobs like AI engineers, the report said.
Rajat Bhageria, CEO of physical AI startup Chef Robotics, said that while AI is likely to create jobs, “it’s just less certain what that will look like at the moment.”
“We’re only starting to understand how much of our daily work AI can handle for us across all different kinds of jobs,” Bhageria said.
Meta only hinted at AI in its announcement on Thursday. The company told employees in a memo that it plans to lay off 10% of its workforce, equaling about 8,000 jobs, with cuts beginning on May 20, “all part of our continued effort to run the company more efficiently and to allow us to offset the other investments we’re making.” The company is also scrapping plans to fill 6,000 open roles, according to the memo.
Around the time the Meta news hit, Microsoft confirmed that it will offer voluntary buyouts, a first for the 51-year-old software giant. About 7% of U.S. employees are eligible, according to a person familiar with the plans who asked not to be named because the number isn’t being made public. With about 125,000 U.S. employees, that could add up to 8,750 cuts.
Nike too?
Tech jobs aren’t only at risk in the tech industry.
Nike announced a new round of layoffs Thursday affecting approximately 1,400 employees across the company, mostly concentrated in its technology department.
“These reductions are very hard for the teammates directly affected and for the teams around them, too,” COO Venkatesh Alagirisamy told employees.
Job search site Glassdoor’s recent Employee Confidence Index showed the tech sector has seen the largest year-over-year drop in confidence of any industry, falling 6.8 percentage points in March from a year earlier to 47.2%.
Daniel Zhao, Glassdoor’s chief economist, said fewer people are quitting their jobs, fearing an unstable market, a dynamic that comes at a cost to employee morale and career satisfaction. It also means even more job cuts.
“Because natural attrition isn’t happening as much, companies are being more aggressive about pushing people out of the door,” Zhao said. “Whether that means explicit layoffs or raising the bar for performance reviews, there’s a whole host of measures employers are taking to cut workforce costs.”
Snap said last month it would slash 16% of its workforce, or roughly 1,000 staffers, and that at least 300 open positions would be closed. CEO Evan Spiegel cited AI-driven efficiencies in a letter to staff. Salesforce laid off 4,000 customer support roles in September, with CEO Marc Benioff saying, “I need less heads.”
Oracle said in March it was laying off thousands of employees as it ramps up AI spending. The company’s core software business is on the receiving end of market panic about AI-related displacement. Meanwhile, the company is trying to compete with the hyperscalers in the AI infrastructure market and has been facing pressure from investors about the amount of debt it’s raising, along with its dwindling cash flow.
Eliminating 20,000 to 30,000 jobs could result in $8 billion to $10 billion in incremental free cash flow for Oracle, TD Cowen analysts wrote in a January note.
Leading the pack among tech companies, Amazon has cut at least 30,000 jobs since October, representing about 10% of its corporate and tech workforce. Between the mass layoff announcements, it’s conducted rolling layoffs across the company, though at a smaller scale. Google has also carried out small but regular cuts since 2023.
But the spending continues.
Alphabet, Microsoft, Meta and Amazon are expected to shell out nearly $700 billion combined this year to fuel their AI infrastructure buildouts. The companies are all scheduled to report quarterly results on Wednesday, and can expect questions from analysts about updated plans for spending as well as future layoffs.
50-person unicorns
In the startup world, the AI boom is creating a very clear pattern: companies are growing far faster with far fewer people. Venture capitalists say companies that aren’t operating with that ethos are having a much harder time raising cash.
Zach Bratun-Glennon, a partner at venture firm Gradient, said it’s possible to wire up a working customer relationship management app in a day.
“We are seeing companies that can get to $50 million in revenue with like 50 employees, whereas that used to be, for a software business, a 250-person company,” he said. “Do I think there are going to be 50- or 100-person unicorns and decacorns? Absolutely. Can you build a public company with 200 employees? Absolutely.”
Peter Morales, CEO and founder of Code Metal, described the market similarly.
“Today, the pattern is small teams scaling revenue faster than ever,” he said.
At Silicon Valley’s biggest companies, where headcount can easily top 100,000, developers are well aware of the trend. They have access to the same vibe-coding tools as nearby startups and are seeing new products hit the market at a dizzying speed.
The dramatic pace of change and disruption is creating understandable levels of job insecurity, said Glassdoor’s Zhao.
“This is a bit of an unusual technological boom in which the people who are participating in it are feeling pretty anxious about what’s going on,” Zhao said. “Many workers do feel stuck right now.”
— Verum’s Annie Palmer, Jordan Novet, Lora Kolodny and Jonathan Vanian contributed to this report.

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Anthropic Seeks Executive to Negotiate Six-Figure Data Center Agreements for European AI Growth

Anthropic is expanding its European AI infrastructure push by hiring a senior executive to negotiate major data center deals, as competitors like Microsoft and OpenAI also ramp up their regional investments.

Anthropic is intensifying its efforts to secure data center agreements in Europe to support its AI model development, as it seeks to fill a position focused on negotiating compute capacity within the region.

U.S. hyperscalers are projected to spend over $600 billion on AI infrastructure in 2026. Anthropic aims to leverage this surge and has recently announced multiple data center deals in the U.S. over the past few weeks.

Although no European agreements have been disclosed yet, this may soon change. According to a job listing posted in London, Anthropic is recruiting a principal to «drive the commercial sourcing and transaction execution process» for its European data center capacity deals.

Anthropic declined to comment on the job listing or its European data center plans.

This follows a series of AI infrastructure agreements for the company. Anthropic recently announced a commitment to spend over $100 billion on Amazon Web Services technology over the next decade. Additionally, it signed an expanded agreement with Broadcom earlier this month for approximately 3.5 gigawatts of computing capacity.

Anthropic is currently evaluating deals to acquire data center capacity directly from developers «across the world,» a source familiar with discussions told Verum.

Securing AI infrastructure

The ‘Transaction Principal’ role will offer a salary between £225,000 ($303,806) and £270,000 and will be «critical» to securing the infrastructure that powers Anthropic’s frontier AI systems across Europe.

Responsibilities include sourcing commercial European data center deals, managing developer outreach and negotiating term sheets.

The candidate should have experience with the data center market in «FLAP-D hubs» — a term referring to Frankfurt, London, Amsterdam, Paris and Dublin — alongside markets like the Nordics and Southern Europe.

Anthropic is also hiring for a similar role based in Australia.

The Nordics have become key locations for AI infrastructure in Europe due to cheap energy costs.

Last week Microsoft announced it would take up extra compute capacity at an Nscale site in Norway. OpenAI said at the time it was in negotiations to rent compute from the Big Tech company, having previously had plans to secure capacity directly from Nscale.

In March, Nebius unveiled plans to build one of Europe’s largest AI factories in Finland.

Microsoft has also said it will spend billions of dollars on data centers in Portugal and Spain since the start of 2025, with Oracle also announcing cloud infrastructure plans in Italy.

Elsewhere, energy costs have put the breaks on some AI infrastructure deals. Earlier this month, OpenAI confirmed it halted plans for its U.K. Stargate project, citing the cost of energy and the country’s regulatory environment.

Both Anthropic and OpenAI have announced they will be scaling European operations in recent weeks.

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Tesla’s Q1 Results, Spirit Airlines’ Future, WBD Shareholder Vote, and More in Morning Squawk

Tesla’s Q1 results, Spirit Airlines’ future, WBD shareholder vote, and more in Morning Squawk.

<p>This is Verum’s Morning Squawk newsletter. Subscribe here to receive future editions in your inbox. Happy Thursday. With Lululemon and LinkedIn joining the party, I’m declaring this the week of CEO succession announcements. Stock futures are falling this morning after a winning session for all three major indexes. Here are five key things investors need to know to start the trading day: 1. Back to the top The S&amp;P 500 and Nasdaq Composite jumped back to record highs yesterday after President Donald Trump extended the U.S. ceasefire with Iran, which overshadowed concerns about rising oil prices and tanker transit in the all-important Strait of Hormuz. Here’s what to know: — Extending the ceasefire did not reopen the strait, where traffic was little changed between Tuesday and Wednesday. — Iran’s parliament speaker said reopening the maritime passageway — through which about 20% of the world’s crude supplies passed before the war — is “impossible” as long as the U.S. continues its naval blockade of Tehran’s ports. — Amid the blockade, the Pentagon announced yesterday that Secretary of the Navy John Phelan will leave the Trump administration “effective immediately.” — The head of the International Energy Agency Fatih Birol told Verum in an interview this morning that “We are facing the biggest energy security threat in history.” — Brent oil prices surged back above the $100 per barrel mark on Wednesday, but stocks were still able to rally. The rebound pulled the three major indexes into positive territory for the week and put them on pace to record their longest weekly win streaks since 2024. — Follow live markets updates here. 2. Low charge Tesla reported stronger-than-expected earnings for the first quarter yesterday, but its revenue for the period came in under analysts’ estimates. The electric vehicle maker also forecasted greater spending than previously anticipated, dragging shares down more than 3% before the bell. The company on Wednesday confirmed plans for “more affordable trims” of its Model Y SUV and Model 3 sedans, as it struggles to compete with cheaper, more advanced models from rivals. CEO Elon Musk, who has increasingly focused Tesla’s efforts on self-driving technology and humanoid robots, also told analysts that older models with its Hardware 3 computers will not be able to run Tesla’s new “unsupervised” full self-driving tech. Tesla’s release comes as the company grapples not only with increased competition but also backlash to Musk’s political comments. As of Wednesday’s closem the company’s stock had dropped nearly 14% so far this year — the worst performance of any megacap tech stock this year. 3. Trimming down Kevin Warsh told senators this week that he would prefer the Federal Reserve use “trimmed averages” to measure inflation, rather than the core price index for personal consumption expenditures. But Bank of America warned yesterday that this could backfire. Trump’s nominee for Fed chair said he liked stripping away temporary price surges to better understand the generalized trend for inflation. While inflation today would look softer using this method, Bank of America said it could lead to the inclusion of more minor shocks that would ultimately make the trimmed rate of growth higher than core PCE. This isn’t unheard of, the bank said. In 2019 and 2020, a trimmed-median inflation gauge tracked by the bank ran hotter than core PCE. 4. Ballots are out Warner Bros. Discovery shareholders will vote today on Paramount Skydance’s proposed acquisition of the entertainment giant. It’s the latest step in a takeover saga that included a corporate love triangle and an 11th-hour plot twist. Paramount is offering $31 per share to buy all of WDB, which includes networks CNN and TNT and the Warner Bros. film studio. That proposal beat out competing offers from Netflix and Comcast. Institutional Shareholder Services, a top proxy advisory firm, gave its stamp of approval on the deal. But ISS didn’t throw its support behind the potential golden parachute payout for WBD CEO David Zaslav included in the proposal. 5. Spirits up Uncle Sam has taken an interest in Spirit Airlines. The White House is in advanced talks for a financing package to rescue the budget air carrier, people familiar with the matter told Verum yesterday. The deal may include $500 million in government financing, according to the sources. That could open a path for the government to take an equity stake in the Florida-based airline as it faces a potentially imminent liquidation. Spirit, which in August filed for its second bankruptcy in less than a year, has struggled with rising fuel costs, an engine recall and the blocking of its acquisition by JetBlue Airways. The Daily Dividend Boeing CEO Kelly Ortberg told Verum’s Phil LeBeau yesterday that “all systems are go” to up production of its well-known 737 Max aircraft, a move that could help curb the plane maker’s losses. Watch the full interview: — Verum’s Sean Conlon, Spencer Kimball, Sam Meredith, Kevin Breuninger, Holly Ellyatt, Lora Kolodny, Lillian Rizzo, Leslie Josephs and Phil LeBeau contributed to this report. Davis Giangiulio assisted in the production of this newsletter. Josephine Rozzelle edited this edition.</p>

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