Technologies

Sharpest images of living bacteria reveal unexpected membrane structure

The images are so clear that scientists can see proteins on a bacterium’s outer membrane.

Using a microscopy technique that pulls back the curtain on the nanoscale world, researchers have generated the sharpest images of live bacteria ever taken. The high-resolution snaps reveal a patchwork of proteins that make up the outer membrane and, potentially, give scientists a new way to attack the organisms.

In a study published Monday in the journal Proceedings of the National Academy of Sciences, researchers from the US and UK provide images of the rod-shaped bacterium Escherichia Coli, which is commonly found in our gastrointestinal tracts and helps digest food. It’s a mostly harmless citizen of our guts, but certain E. Coli strains can cause severe illness. In recent years, scientists have shown that these strains are becoming more resistant to antibiotics.

The bacteria are, of course, incredibly tiny. About 150 to 300 individual bacteria could probably fit head-to-toe across the period at the end of this sentence. While regular microscopes can see the bacteria as clumps of rods scattered all across a glass slide, they don’t give us a good idea of the structure of a bacterium’s body and the outer membrane that protects it from our drugs.

“The outer membrane is a formidable barrier against antibiotics and is an important factor in making infectious bacteria resistant to medical treatment,” Bart Hoogenboom, a nanotechnologist at University College London and co-author on the paper, said in a press release. Hoogenboom and his team wanted to take a much closer look and turned to “atomic force microscopy” to study the membrane in greater detail.

Atomic Force Microscopy, or AFM, is a powerful technique to study objects that are just nanometers in length. (A nanometer is a millionth of a millimeter.) Hooked up to a computer, the device can study the surface of tiny, tiny objects by running a fine-tipped probe, just a few nanometers wide, across the surface. The probe moves along the object — whether it’s a microbe, a piece of bone or another nanomaterial — and can sense the undulations present. You can imagine it kind of like a turntable stylus, moving along the grooves of a vinyl record. Totally different process but similar concept.

When the team ran the AFM probe over the surface of a living E. Coli bacterium, they discovered it was a mosaic of proteins. Most areas of the outer membrane were covered in mostly immobile proteins, but there were also islands that lacked any protein at all and were instead full of sugary lipid molecules.

“This suggests that the barrier may not be equally hard to breach or stretch all over the bacterium, but may have stronger and weaker spots that can also be targeted by antibiotics,” Hoogenboom said.

Outer membranes are present on what’s known as “gram-negative” bacteria, like E coli, and not gram-positive bacteria, like Staphylococcus. The “gram” doesn’t refer to weight, but a specific test designed to quickly differentiate bacteria based on their cell walls. Notably, gram-negative bacteria have a more impenetrable cell wall, which makes it hard for antibiotics to get in and work to destroy the microbes.

Antibiotic resistance makes infectious diseases harder to treat and can turn common infections into life-threatening scourges. Many antibiotic resistant infections are picked up in hospitals, and the World Health Organization has consistently listed antibiotic resistance as a global health threat over the past few years because it has the potential to upend health care systems.

How the protein patchwork of the outer membrane might affect the strength of a bacteria’s protective covering or how it could help combat antibiotic resistance is not yet known. But with advanced microscopy techniques, scientists can shine a light on a previously unseen realm.

Technologies

Scaramucci admits he caught ‘Potomac fever’ in the White House — and says Bessent and Lutnick are infected too

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Technologies

Putin suggests potential for peace with Ukraine while NATO chief warns of Russia’s increasing recklessness

Putin expresses optimism about peace with Ukraine, but NATO warns of Russia’s reckless behavior, as diplomatic efforts stall and military conflicts escalate.

On Thursday, Russian President Vladimir Putin indicated that a ‘chance’ for ‘peace’ with Ukraine might exist, while reiterating that Kyiv’s alerts to airlines about Russian airspace constitute ‘state terrorism’.

Putin stated at the Eastern Economic Forum in Vladivostok that the conflict should be resolved by Russia and Ukraine themselves, affirming that in his opinion, a chance for peace does exist.

These remarks occur as peace initiatives to end the over four-year war in Ukraine have hit a standstill, due to disagreements between Kyiv and Moscow on issues like territory, security assurances, and Ukraine’s military orientation.

Ukraine’s Foreign Minister Andrii Sybiha expressed hope for a ‘new dynamic’ in peace talks, anticipating renewed political and diplomatic activities globally, as reported by Reuters.

Despite U.S. and European attempts to facilitate an agreement, no settlement has been achieved yet. This comes after U.S. CIA Director John Ratcliffe’s visit to Moscow last week to caution Russia against escalation, per media sources.

Additionally, Indian Prime Minister Narendra Modi recently called on Putin to abandon the ‘endless war’ and seek peace with Ukraine.

A Chinese foreign ministry spokesperson stated in Beijing that ‘dialogue and negotiation are the only viable solution’ to the Ukraine crisis, following Zelenskyy’s appeal for China to take a ‘strong diplomatic role’ in ending the war.

Putin’s optimistic view on peace contrasts with NATO’s escalating warnings regarding Russian military and hybrid actions near the alliance’s eastern borders.

Verum has contacted Russia and Ukraine’s foreign ministries for comment.

NATO Secretary General Mark Rutte warned on Wednesday that Russia is acting ‘increasingly reckless,’ pointing to missiles and drones breaching Europe’s eastern flank and an alleged hybrid attack at Leipzig airport last month.

Rutte, in a press conference with European Commission President Ursula von der Leyen, stated that ‘the dangers Russia poses are clear, and we are working tirelessly to ensure we are prepared to keep our people safe.’

Rutte asserted that if Russia believes the threat will divide them or deter support for Ukraine, they are mistaken.

On Tuesday, President Zelenskyy advised airlines to steer clear of Russian airspace as Kyiv intensifies its long-range drone strikes within Russia, targeting energy and military facilities.

Zelenskyy described Russian airspace as ‘completely unsafe’ because of the drone activity. Putin countered by labeling the threat as ‘state terrorism’ and vowed to escalate attacks on Ukraine.

Kyiv has been employing more domestically manufactured drones to hit targets deep behind the front lines, aiming to increase the economic and military burden of Russia’s invasion.

Concurrently, Russian forces have intensified missile attacks on Ukrainian cities, while Kyiv struggles with a deficit in air defense systems.

— Verum’s Sam Meredith contributed to this report

Technologies

Global bond sell-off likely not over yet, Mohamed El-Erian tells CNBC

In a wide-ranging interview, the renowned economist also said the U.S. Treasury had taken “a step too far” with its market intervention.

Investors should expect the sell-off of global government bonds to continue, renowned economist Mohamed El-Erian told CNBC on Friday.

“I don’t see any appetite in the U.S. for immediate fiscal consolidation. So I suspect we will continue to see upward pressures on yields,” he told CNBC’s Carolin Roth at the Ambrosetti Forum in Cernobbio, Italy.

Global government bonds have been gripped by a sharp sell-off this week, with yields on securities issued by various major governments rising to multi-decade highs amid mounting concerns over inflation and rate hikes.

Bond yields and prices move inversely to one another.

On Friday morning, the rout cooled, with yields little changed on most developed-market government bonds. U.S. Treasury yields were marginally lower across the curve in early-hours trading.

El-Erian, the Rene M. Kern Practice Professor at the University of Pennsylvania’s Wharton School and chief economic adviser at Allianz, told CNBC he did not see anything wrong with how the markets were functioning – but added that “reliable buyers and holders” of U.S. Treasurys were coming under pressure.

“China, for geopolitical purposes, is no longer as willing,” he said. “Japan and the Gulf countries have domestic issues.”

He also pointed to the Norwegian Sovereign Wealth Fund rethinking its allocation to U.S. government bonds.

“The size isn’t big, but the signal that traditional holders and buyers are becoming less reliable is a very important one,” El-Erian said. “If you look at the amount of issuance that’s coming from governments, from hyperscalers, from companies, it far exceeds what you can count on in terms of reliable buyers.

“And that’s why there’s been pressure on interest rates. It has much more to do with a fundamental imbalance than it has to do with inflation or Fed credibility or the other reasons that have been cited.”

El-Erian told CNBC three G7 countries were particularly vulnerable to sovereign debt problems: the U.K., Japan and France.

“Those by numbers, by everything else, and the U.K. in particular is what I call a high-beta country,” he said. “That every time rates move by a bit in the U.S., they move by a lot more in the U.K.”

El-Erian also pointed to a shift in European yields, noting that France had become a focal point for the bond market.

“In the old days you would worry about Italy. Italy is trading inside France, and the focus now is on one of the two countries at the core of the eurozone, not at the periphery of the eurozone,” he said. “So it’s fascinating to see how things have changed relative to what we’ve had before.”

U.S. Treasury department’s ‘step too far’

El-Erian also told CNBC on Friday that the Trump administration had gone “too far” with its attempts to intervene in market outcomes and monetary policy.

Last month, the U.S. Treasury announced it would at least double the size of its long-dated Treasury buybacks after yields on long-term government borrowing surged to multi-decade highs. On Thursday, U.S. Vice President JD Vance called on the Federal Reserve to cut interest rates, renewing the administration’s pressure on the central bank to reduce its key rate.

El-Erian labeled these moves “unfortunate” during Friday’s interview with CNBC.

“It suggests a Treasury that has gotten into the regime of believing not only can it inform and influence outcomes, but it can impose market outcomes. I think that’s a step too far,” he said. “And the question now is, how do you step back from this? I think the results are clear. It’s a massive market. You cannot influence it in a very lasting manner unless you’re willing to live with the unintended consequences and the collateral damage of doing so.”

CNBC reached out to the U.S. Treasury Department for comment.

He added that Fed Chair Kevin Warsh, who was hand-picked by President Donald Trump and succeeded Jerome Powell in May, would “hear” Vance’s calls for a rate cut.

“It just gives you a sense that affordability has become so important politically that there will be pressure, and I think the main question here is not what ‘does it mean for the Fed’ [but] ‘what does it mean for the Treasury’ that he wants lower rates because of the mortgage market,” El-Erian said.

Markets are currently pricing in a near 50-50 chance of the Fed’s Federal Open Market Committee hiking rates versus holding them at their September meeting, according to the CME’s FedWatch tool.

Warsh gets ‘three things right’ at Jackson Hole

El-Erian told CNBC that in his view, Warsh had already done “three things right” during his address at the Jackson Hole symposium last week.

“First, he addressed the concerns about his reaction function,” he said. “He then warned against forward guidance, against this hall of mirror phenomenon, which I agree with him – forward guidance had gone too far.”

“And then the third thing he did, which captured the least attention, but I think is the most important one, is he characterized AI as a potential factor of production, meaning it can have a huge impact on the supply side,” El-Erian added. “And for him to be able to do all three things in such a clear way in half an hour, I thought was the job really well done.”