Technologies

Sharpest images of living bacteria reveal unexpected membrane structure

The images are so clear that scientists can see proteins on a bacterium’s outer membrane.

Using a microscopy technique that pulls back the curtain on the nanoscale world, researchers have generated the sharpest images of live bacteria ever taken. The high-resolution snaps reveal a patchwork of proteins that make up the outer membrane and, potentially, give scientists a new way to attack the organisms.

In a study published Monday in the journal Proceedings of the National Academy of Sciences, researchers from the US and UK provide images of the rod-shaped bacterium Escherichia Coli, which is commonly found in our gastrointestinal tracts and helps digest food. It’s a mostly harmless citizen of our guts, but certain E. Coli strains can cause severe illness. In recent years, scientists have shown that these strains are becoming more resistant to antibiotics.

The bacteria are, of course, incredibly tiny. About 150 to 300 individual bacteria could probably fit head-to-toe across the period at the end of this sentence. While regular microscopes can see the bacteria as clumps of rods scattered all across a glass slide, they don’t give us a good idea of the structure of a bacterium’s body and the outer membrane that protects it from our drugs.

«The outer membrane is a formidable barrier against antibiotics and is an important factor in making infectious bacteria resistant to medical treatment,» Bart Hoogenboom, a nanotechnologist at University College London and co-author on the paper, said in a press release. Hoogenboom and his team wanted to take a much closer look and turned to «atomic force microscopy» to study the membrane in greater detail.

Atomic Force Microscopy, or AFM, is a powerful technique to study objects that are just nanometers in length. (A nanometer is a millionth of a millimeter.) Hooked up to a computer, the device can study the surface of tiny, tiny objects by running a fine-tipped probe, just a few nanometers wide, across the surface. The probe moves along the object — whether it’s a microbe, a piece of bone or another nanomaterial — and can sense the undulations present. You can imagine it kind of like a turntable stylus, moving along the grooves of a vinyl record. Totally different process but similar concept.

When the team ran the AFM probe over the surface of a living E. Coli bacterium, they discovered it was a mosaic of proteins. Most areas of the outer membrane were covered in mostly immobile proteins, but there were also islands that lacked any protein at all and were instead full of sugary lipid molecules.

«This suggests that the barrier may not be equally hard to breach or stretch all over the bacterium, but may have stronger and weaker spots that can also be targeted by antibiotics,» Hoogenboom said.

Outer membranes are present on what’s known as «gram-negative» bacteria, like E coli, and not gram-positive bacteria, like Staphylococcus. The «gram» doesn’t refer to weight, but a specific test designed to quickly differentiate bacteria based on their cell walls. Notably, gram-negative bacteria have a more impenetrable cell wall, which makes it hard for antibiotics to get in and work to destroy the microbes.

Antibiotic resistance makes infectious diseases harder to treat and can turn common infections into life-threatening scourges. Many antibiotic resistant infections are picked up in hospitals, and the World Health Organization has consistently listed antibiotic resistance as a global health threat over the past few years because it has the potential to upend health care systems.

How the protein patchwork of the outer membrane might affect the strength of a bacteria’s protective covering or how it could help combat antibiotic resistance is not yet known. But with advanced microscopy techniques, scientists can shine a light on a previously unseen realm.

Technologies

Today’s NYT Strands Hints, Answers and Help for June 29, #483

Here are hints and answers for the NYT Strands puzzle for June 29, No. 483.

Looking for the most recent Strands answer? Click here for our daily Strands hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections and Connections: Sports Edition puzzles.

I love today’s NYT Strands puzzle! It’s maybe a bit easier than usual once you understand the theme, but then it gets, well, really colorful. And the spangram even makes a themed shape! If you need hints and answers, read on.

I go into depth about the rules for Strands in this story.

If you’re looking for today’s Wordle, Connections and Mini Crossword answers, you can visit CNET’s NYT puzzle hints page.

Read more: NYT Connections Turns 1: These Are the 5 Toughest Puzzles So Far

Hint for today’s Strands puzzle

Today’s Strands theme is: Hue are my sunshine.

If that doesn’t help you, here’s a clue: Why are there so many songs about these?

Clue words to unlock in-game hints

Your goal is to find hidden words that fit the puzzle’s theme. If you’re stuck, find any words you can. Every time you find three words of four letters or more, Strands will reveal one of the theme words. These are the words I used to get those hints but any words of four or more letters that you find will work:

RAIN, SING, SIGN, ROLL, LINE, BILL, BAGS, GABS, HOUSE, GRAIN, RAINS

Answers for today’s Strands puzzle

These are the answers that tie into the theme. The goal of the puzzle is to find them all, including the spangram, a theme word that reaches from one side of the puzzle to the other. When you have all of them (I originally thought there were always eight but learned that the number can vary), every letter on the board will be used. Here are the nonspangram answers:

ORANGE, YELLOW, GREEN, BLUE, INDIGO, VIOLET

Today’s Strands spangram

Today’s Strands spangram is CHASINGRAINBOWS. To find it, look for the C that’s six letters down on the first row on the left, and wind around… in the shape of a rainbow! Nice one, puzzle-makers!

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for June 29, #279

Here are hints and the answers for the NYT Connections: Sports Edition puzzle, No. 279, for June 29.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition might be tough. But all you Hoosiers will nail the yellow category, I think. Read on for hints and the answers.

Connections: Sports Edition is out of beta now, making its debut on Super Bowl Sunday, Feb. 9. That’s a sign that the game has earned enough loyal players that The Athletic, the subscription-based sports journalism site owned by the Times, will continue to publish it. It doesn’t show up in the NYT Games app but now appears in The Athletic’s own app. Or you can continue to play it free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Think Indianapolis.

Green group hint: Multitalented.

Blue group hint: They forgot Air Bud!

Purple group hint: Lace up your skates.

Answers for today’s Connections: Sports Edition groups

Yellow group: Indiana sports teams, in singular form.

Green group: Skills of a five-tool baseball player.

Blue group: Basketball movies.

Purple group: PWHL stars.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is Indiana sports teams, in singular form. The four answers are Boilermaker, Colt, Hoosier and Pacer.

The green words in today’s Connections

The theme is skills of a five-tool baseball player. The four answers are fielding, power, speed and throwing.

The blue words in today’s Connections

The theme is basketball movies. The four answers are Air, Blue Chips, Glory Road and He Got Game.

The purple words in today’s Connections

The theme is PWHL stars. The four answers are Fast, Fillier, Knight and Poulin.

Technologies

Your Phone’s a Germ Magnet. How to Disinfect It Properly

Want to keep your iPhone or Android germ-free? Follow these phone cleaning tips.

Your phone goes everywhere with you — on your commute, your lunch break, even the bathroom (don’t lie). But for something that spends so much time in your hands and against your face, it’s probably way dirtier than you think. In fact, studies have shown that the average smartphone can carry more germs than a toilet seat. Yeah, really.

All that touching, tapping, swiping and setting it down on random surfaces adds up fast. If you’re not regularly disinfecting your phone, you’re basically carrying a pocket-sized petri dish. The good news? Cleaning it the right way is quick, easy and doesn’t require fancy gear. Here’s how to sanitize your device safely — without damaging the screen or frying your electronics..

The Federal Communications Commission suggests disinfecting your phone daily, but not all cleaning methods are safe. Harsh chemicals and abrasive materials can damage protective coatings and potentially harm your screen. To keep your phone both clean and intact, it’s crucial to use the right cleaning techniques.

We’ll guide you through the best methods and products for keeping your device germ-free, from iPhones to Samsungs, and whatever their level of water resistance may be.

For more cleaning tips, here’s how to clean wireless earbuds and AirPods.

What are the best products for daily cleaning?

After touching surfaces that see a lot of action from the public — such as door handles, seats on public transportation, grocery carts and gas pumps — you might think you need a heavy-duty cleaning agent to use on your phone. However, you should avoid rubbing alcohol or products made of straight alcohol, since they can damage the protective coatings that prevent oil and water from harming your screen.

Some suggest making your own alcohol-water mix, but getting the concentration wrong can damage your phone. The safest option is using disinfectant wipes with 70% isopropyl alcohol. For daily cleaning, consider a UV light product like PhoneSoap, which kills 99.99% of germs and bacteria. We can also turn to phone manufacturers and cell service companies for guidance, too.

Apple now approves using Clorox Wipes and similar disinfectants, which was not recommended before the pandemic since they were thought to be too abrasive on the screen’s coating. AT&T advises spraying a 70% isopropyl alcohol solution on a soft, lint-free cloth and wiping your device down. Samsung also recommends using a 70% alcohol solution with a microfiber cloth. Always make sure your phone is powered off before cleaning it.

What are the best methods for removing fingerprints, sand and makeup?

Sometimes your phone needs a more specific treatment when washing up. The recommended process for daily cleaning may not be enough to remove pesky grains of sand after a beach vacation or tough foundation stains.

Get rid of fingerprints

Fingerprint smudges are inevitable since your skin produces oils. Every time you pick up your phone, your screen will get fingerprints. The safest way to make your screen print-free is with a microfiber cloth. For a deeper clean, dampen the cloth with distilled water (never apply water directly to the screen) and wipe down the surface. This works for the back and sides of your phone as well.

Alternatively, try a microfiber screen cleaner sticker that sticks to the back of your phone for easy wiping.

Remove sand and small particles

Grains of sand and lint can easily get stuck in your phone’s ports and crevices. To remove it, we recommend you use Scotch tape. Press it along the creases and speaker, then roll it up and gently insert it into the ports. The tape will pull out any debris. You can then just simply throw away the tape for easy cleanup.

For smaller speaker holes, use a toothpick gently or a small vacuum crevice tool to suck out the debris. These tools work well for other small appliances or hard-to-reach areas in your car too.

Cleanse makeup off your phone screen

When you wear makeup and skin care products, such as foundation and moisturizers, you’ll leave residue on your phone screen. While makeup remover works for your face, it’s not safe for screens due to potentially harmful chemicals. Instead, try a screen-safe makeup remover like Whoosh, which is alcohol-free and gentle on all screens.

Alternatively, use a damp microfiber cloth to clean your phone, then wash the cloth afterward. Make sure your cloth is only slightly wet to avoid soaking your phone in water.

What if my phone is waterproof?

For waterproof phones (IP67 and above), it’s best to clean the device with a damp cloth instead of submerging or running it under water — even if the phone advertises that it can withstand submersion for a certain amount of time.

Afterward, dry your phone with a soft cloth, ensuring all ports and speakers are patted dry. While your phone can withstand water, submerging it can lead to water in the ports, delaying charging. Remember, water resistance is meant for accidents, not swimming or regular cleaning.

Things to avoid when cleaning your phone

We’ve already covered why you should avoid makeup remover and rubbing alcohol, but those aren’t a comprehensive list of harmful cleaning agents. Here are a few other items and products you should never use to clean your phone:

Hand sanitizer: Fragrances and ethyl alcohol found in many sanitizers can harm your phone.
Window or kitchen cleaners: Harsh cleaners can strip the protective coating on your phone and leave it more vulnerable to scratches.
Paper towels: Paper can shred, making the debris on your phone much worse, and the rough texture can leave scratches on your screen.
Dish and hand soap: Most soaps require you to combine them with water, and since you should keep water away from your phone, it’s best to stick to a damp cloth.
Vinegar: Like cleaners and alcohols, vinegar will strip your phone screen’s coating.
Compressed air: Blowing intense and direct air into your phone’s portals can cause damage, especially to your mic. Apple specifically warns iPhone owners not to use compressed air.