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Ivermectin and COVID-19: Why poison centers are getting calls about this controversial drug

Is this a miracle pill or a sham?

Since the start of the COVID-19 pandemic, some medical professionals have reviewed already available drugs to see if they could be used as effective treatments. Ivermectin, an anti-parasitic, was administered to some patients across the globe, with seemingly positive effects. However, more studies show it has little to no effect when it comes to treating COVID-19. There’s also been an increase in calls to poison centers by people who are taking ivermectin intended for animals.

On one side, there are doctors who say ivermectin could help end the pandemic if used globally. On the other are public health officials who have reviewed the data and say the drug’s effectiveness against COVID-19 isn’t conclusive.

Here’s everything you need to know about ivermectin and its use for COVID-19.

What is ivermectin?

Ivermectin is an anti-parasitic medicine «that works by altering cellular channels,» said Dr. Soumi Eachempati, CEO of Cleared4 and former professor of surgery and public health at Weill Cornell Medical College. The drug inhibits some viruses from infecting cells, thus preventing the virus from spreading. Ivermectin is usually given to treat parasitic infections like lice and Strongyloides, according to Eachempati.

Scientists at pharmaceuticals giant Merck discovered ivermectin in 1975 and began to use it to treat scabies, river blindness and other parasitic diseases carried by worms and lice starting in 1981. It’s on the World Health Organization’s list of essential medicines for a basic health care system. More than 250 million people take the drug across the globe each year, and it’s effective for animals as well.

The drug is considered safe when taken in appropriate dosages. Side effects for the ivermectin vary depending on whether it’s taken orally to treat intestinal infections or topically for skin infections. Oral tablets can cause drowsiness, nausea, vomiting and, in very rare cases, an increase in heart rate and seizures. Side effects for the topical ivermectin can include skin rash and irritation, while dry skin and stinging pain are severe and rare.

Can ivermectin be used to cure COVID-19?

This is where things get complicated. Public health agencies, including the Federal Drug Administration, the National Institutes of Health and the World Health Organization, don’t suggest ivermectin’s use to treat COVID-19. They cite the lack of data from large, randomized trials confirming the drug’s effectiveness to treat the disease.

Doctors who cited multiple smaller studies and firsthand experience say otherwise. They claim ivermectin does work to prevent people from developing symptoms from COVID-19 and can shorten recovery time for those already infected.

What do the public health agencies say about ivermectin use for COVID-19 treatment?

The FDA said in March it hasn’t approved the use of ivermectin to treat COVID-19. It warned that large doses of the drug are «dangerous and can cause serious harm.» The agency also advised against human use of ivermectin produced for animals, such as cows and horses, as the doses aren’t the same and could contain ingredients intended only for animals.

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A growing number of people have been taking ivermectin for animals as word’s spread on social media about its possible use against COVID-19. This has resulted in some people calling state poison centers after taking the drug, since the medication is intended for animals. On Aug. 20, the Mississippi State Department of Health sent out an alert regarding the number of calls its poison center received, with 70% related to the «ingestion of livestock or animal formulations of ivermectin purchased at livestock supply centers

In April, the FDA reaffirmed in a post on its website that ivermectin isn’t approved to treat COVID-19 nor has it been given emergency use authorization.

The NIH said in February there was insufficient data to «recommend either for or against the use of ivermectin for the treatment of COVID-19.» It did say lab tests found the drug stopped the reproduction of the SARS-CoV-2 virus that cause the disease. However, to be effective, the dosages would need to be «100-fold higher than those approved for use in humans.»

While some clinical studies showed ivermectin to have no benefit, the NIH said others saw a lower mortality rate among patients. However, those studies were incomplete or had methodological limitations such as small sample sizes or patients receiving additional medicine along with ivermectin, according to the NIH.

The WHO said in March the current evidence on the use of ivermectin for treatment of COVID-19 was «inconclusive.»

A doctor in Arkansas who prescribed the drug to patients is under investigation by the state medical board, according to a report from CNN. He reportedly gave ivermectin prescriptions to prisoners at the county jail where he was contracted to provide medical services.

Who says ivermectin is a treatment, and what information do they have?

Ivermectin’s potential use as a COVID-19 therapeutic made headway last December during a Senate Homeland Security Committee meeting called Focus on Early Treatment of COVID-19. Dr. Pierre Kory, a pulmonary and critical care specialist, testified about the drug’s usage for treatment of the disease.

«Ivermectin is highly safe, widely available, and low cost,» Kory said in the Senate meeting. «We now have data from over 20 well-designed clinical studies, 10 of them randomized, controlled trials, with every study consistently reporting large magnitude and statistically significant benefits in decreasing transmission rates, shortening recovery times, decreasing hospitalizations, or large reductions in deaths. These data show that ivermectin is effectively a ‘miracle drug’ against COVID-19.»

During his testimony, Kory referred to a paper he authored — Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 — that was published in the May edition of the American Journal of Therapeutics.

The paper was also included in the Frontiers of Pharmacology journal in January but was then removed in March. Dr. Frederick Fenter, chief executive editor of the journal, said the paper was removed due to «strong, unsupported claims based on studies with insufficient statistical significance, and at times, without the use of control groups.» Fender also said the authors promoted their own specific ivermectin-based treatment, which goes against editorial policies.

A study listed in Kory’s paper involved giving ivermectin to 234 uninfected health care workers in Argentina and found those who received the drug were far less likely to be diagnosed with COVID. For mildly ill patients, an Iraq study saw a quicker recovery time.

There are also studies that show otherwise. A clinical trial of 476 patients found ivermectin didn’t improve the recovery time in patients who had COVID-19. A review of 10 random clinical trials, with more than 1,000 participants, also didn’t find improvements with ivermectin. One Egyptian study claimed to show positive results, but it’s since been redacted over ethical concerns. Another study, of 1,500 patients, found that ivermectin had «no effect whatsoever.»

Merck, the company that discovered ivermectin, released a statement in February saying there was «no scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies» and «no meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease.» It also cited a lack of safety data from major studies.

Why is there controversy over ivermectin?

The debate about ivermectin’s usage to treat COVID-19 has gone from the hospital to social media, exacerbating the discourse as well as the vitriol. While those in support of the drug appear to want an end to the pandemic, their arguments in favor of ivermectin have become fodder for anti-vaxxers and conspiracy theorists.

Groups that have spread misinformation about COVID-19 throughout the pandemic latched onto ivermectin’s usage following Kory’s Senate testimony. Anti-vax groups on Telegram share misinformation about the vaccine while asking where they can buy the drug. Rumble, an alternative video platform to YouTube, has pages of videos falsely saying vaccines are ineffective while advising people to also take ivermectin.

Anti-vax posts and videos can also be found on YouTube, Facebook and Twitter, although the companies are attempting to take these posts down or make them harder to find.

Kory was a guest on the Dark Horse Podcast hosted by Bret Weinstein, a former professor at Evergreen State College, on June 1 to talk about ivermectin. That video was eventually demonetized on YouTube and Weinstein’s channel received a strike, which prevented him from posting content for one week and could lead to its removal if he receives two more strikes within 90 days.

YouTube says its actions on Weinstein’s videos were part of its policies.

«While we welcome open discussions of potential treatments and clinical trials related to COVID-19 on YouTube, based on guidance from the CDC, FDA and other local health authorities, we don’t currently allow content that recommends ivermectin as an effective treatment or prevention method for the virus,» said Ivy Choi, a YouTube spokesperson. «We craft our policies to prevent the risk of egregious real-world harm, and update them as official guidance evolves. We do allow exceptions to our policy about ivermectin, including content that also gives viewers the full context of the FDA’s current position

Because of YouTube’s decision, the controversy over ivermectin grew and became tied to what some claim to be «big tech censorship.»

What is required for ivermectin to get approved for COVID-19 treatment?

For the public health agencies, it’s going to come down to the results of large clinical studies being conducted around the world.

«In the UK, it was announced that ivermectin will be added to the Principle Trial, a large clinical study designed to assess potential COVID therapies for non-hospitalized therapies for patients at higher risk for severe disease,» said Dr. David Shafran, head of pediatrics at telehealth app K Health. «This should demonstrate more definitively the efficacy of ivermectin in early-stage COVID infections. Fingers crossed because it’s a cheap medication with a good safety profile. It would be great to add this to the armament of medication to fight COVID.»

The Oxford University Principle Trial has more than 5,000 participants and will give a three-day course of oral ivermectin treatment to individuals randomly and compare their results to individuals who will receive standard care.

In the US, the NIH is evaluating therapeutics for COVID-19 with its Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) master protocol. ivermectin was added in phase three of ACTIV-6, which will test the effectiveness of repurposed drugs.

«The ACTIV prioritization group, trial team and trial oversight groups continuously track new data on any agent we are studying in our trials and evaluate that data for how it might influence our testing of that agent and the safety/well being of the participants in the trial,» said Dr. Sarah Dunsmore, a program director at the National Center for Advancing Translational Sciences that is part of the NIH.

What’s unclear is how long the whole process will take. The studies need time to be completed, and then the agencies will require additional time to come up with decisions based on the data.

Technologies

An AWS Outage Broke the Internet While You Were Sleeping, and the Trouble Continues

Reddit, Roblox and Ring are just a tiny fraction of the 1,000-plus sites and services that were affected when Amazon Web Services went down, causing a major internet blackout.

The internet kicked off the week the way that many of us often feel like doing: by refusing to go to work. An outage at Amazon Web Services rendered huge portions of the internet unavailable on Monday morning. Sites and services including Snapchat, Fortnite, Venmo, the PlayStation Network and, predictably, Amazon, were unavailable off and on through the start of the day.

The outage began shortly after midnight PT, and took Amazon around 3.5 hours to fully resolve. Social networks and streaming services were among the 1,000-plus companies affected, and critical services such as online banking were also taken down. 

The issues seemed to have been largely resolved as the US East Coast was coming online, but spiked again dramatically after 8 a.m. PT as work began on the West Coast.

AWS, a cloud services provider owned by Amazon, props up huge portions of the internet. So when it went down, it took many of the services we know and love with it. As with the Fastly and Crowdstrike outages over the past few years, the AWS outage shows just how much of the internet relies on the same infrastructure — and how quickly our access to the sites and services we rely on can be revoked when something goes wrong. 

The reliance on a small number of big companies to underpin the web is akin to putting all of our eggs in a tiny handful of baskets. When it works, it’s great, but only one small thing needs to go wrong for the internet to come to its knees in a matter of minutes.

How widespread was the AWS outage?

Just after midnight PT on Oct. 20, AWS first registered an issue on its service status page, saying it was «investigating increased error rates and latencies for multiple AWS services in the US-East-1 Region.» Around 2 a.m. PT, it said it had identified a potential root cause of the issue. Within half an hour, it had started applying mitigations that were resulting in significant signs of recovery. 

«The underlying DNS issue has been fully mitigated, and most AWS Service operations are succeeding normally now,» AWS said at 3.35 a.m. PT. The company didn’t respond to request for further comment beyond pointing us back to the AWS health dashboard.

But as of 8:43 a.m. PT, many services were still impacted, and the AWS status page showed the severity as «degraded.» In a post at that time, AWS noted: «We are throttling requests for new EC2 instance launches to aid recovery and actively working on mitigations.»

Around the time that AWS says it first began noticing error rates, Downdetector saw reports begin to spike across many online services, including banks, airlines and phone carriers. As AWS resolved the issue, some of these reports saw a drop off, whereas others have yet to return to normal. (Disclosure: Downdetector is owned by the same parent company as CNET, Ziff Davis.)

Around 4 a.m. PT, Reddit was still down, while services including Ring, Verizon and YouTube were still seeing a significant number of reported issues. Reddit finally came back online around 4.30 a.m. PT, according to its status page, which was then verified by us.

In total, Downdetector saw over 6.5 million reports, with 1.4 million coming from the US, 800,000 from the UK and the rest largely spread across Australia, Japan, the Netherlands, Germany and France. Over 1,000 companies in total have been affected, Downdetector added.

«This kind of outage, where a foundational internet service brings down a large swath of online services, only happens a handful of times in a year,» Daniel Ramirez, Downdetector by Ookla’s director of product told CNET. «They probably are becoming slightly more frequent as companies are encouraged to completely rely on cloud services and their data architectures are designed to make the most out of a particular cloud platform.»

What caused the AWS outage?

AWS didn’t immediately share full details about what caused the internet to fall off a cliff this morning. Then at 8:43 a.m. PT, it offered this brief description: «The root cause is an underlying internal subsystem responsible for monitoring the health of our network load balancers.»

Earlier in the day it had attributed the outage to a «DNS issue.» DNS stands for the Domain Name System and refers to the service that translates human-readable internet addresses (for example, CNET.com) into machine-readable IP addresses that connect browsers with websites.

When a DNS error occurs, the translation process cannot take place, interrupting the connection. DNS errors are common internet roadblocks, but usually happen on small scale, affecting individual sites or services. But because the use of AWS is so widespread, a DNS error can have equally widespread results.

According to Amazon, the issue is geographically rooted in its US-East-1 region, which refers to an area of North Virginia where many of its data centers are based. It’s a significant location for Amazon, as well as many other internet companies, and it props up services spanning the US and Europe.

«The lesson here is resilience,» said Luke Kehoe, industry analyst at Ookla. «Many organizations still concentrate critical workloads in a single cloud region. Distributing critical apps and data across multiple regions and availability zones can materially reduce the blast radius of future incidents.»

Was the AWS outage caused by a cyberattack?

DNS issues can be caused by malicious actors, but there’s no evidence at this stage to say that this is the case for the AWS outage.

Technical faults can, however, pave the way for hackers to look for and exploit vulnerabilities when companies’ backs are turned and defenses are down, according to Marijus Briedis, CTO at NordVPN. «This is a cybersecurity issue as much as a technical one,» he said in a statement. «True online security isn’t only about keeping hackers out, it’s also about ensuring you can stay connected and protected when systems fail.»

In the hours ahead, people should look out for scammers hoping to take advantage of people’s awareness of the outage, added Briedis. You should be extra wary of phishing attacks and emails telling you to change your password to protect your account.

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Apple Watch Series 11 Deals: How to Save Up to $335 on Apple’s Latest Wearable

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Take Your Apple Watch Experience to the Next Level With These 8 Tips and Tricks

Get the most out of your Apple Watch with these expert-approved tips.

Apple’s smartwatch lineup is getting better year after year. This year is no exception with the new Apple Watch series 11, Apple Watch SE 3 and the Apple Watch Ultra 3. Whether you’ve got a brand new model to get acquainted with or you’re trying out the new features in WatchOS 26, there are options to keep you productive, become more active and take control of your life. These are the features I love the most.


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Swipe between watch faces (again)

Until WatchOS 10.0, you could swipe from the left or right edge of the screen to switch active watch faces, a great way to quickly go from an elegant workday face to an exercise-focused one, for example. Apple removed that feature, likely because people were accidentally switching faces by brushing the edges of the screen.

However, the regular method involves more steps (touch and hold the face, swipe to change, tap to confirm), and people realized that the occasional surprise watch face change wasn’t really so bad. Therefore, as of version 10.2, including the current WatchOS 26, you can turn the feature on by toggling a setting: Go to Settings > Clock and turn on Swipe to Switch Watch Face.

Stay on top of your heart health with Vitals

Wearing your Apple Watch while sleeping offers a trove of information — and not just about how you slept last night. If you don the timepiece overnight, it tracks a number of health metrics. The Vitals app gathers that data and reports on the previous night’s heart rate, respiration, body temperature (on supported models) and sleep duration. The Vitals app can also show data collected during the previous seven days — tap the small calendar icon in the top-left corner.

If you own a watch model sold before Jan. 29, 2024, you’ll also see a blood oxygen reading. On newer watches in the US, that feature works differently because of an intellectual property fight: The watch’s sensors take a reading, and then send the data to the Health app on your iPhone. You can check it there, but it doesn’t show up in the Vitals app.

How is this helpful? The software builds a baseline of what’s normal for you. When the values stray outside normal ranges, such as irregular heart or respiratory rates, the Vitals app reports them as atypical to alert you. It’s not a medical diagnosis, but it can prompt you to get checked out and catch any troubles early.

Make the Wrist Flick gesture second nature

WatchOS 26 adds a new gesture that has quickly become a favorite. On the Apple Watch Series 9 and later, and the Apple Watch Ultra 2 and Ultra 3, Wrist Flick is a quick motion to dismiss incoming calls, notifications or really anything that pops up on the screen. Wrist Flick joins Double Tap as a way to interact with a watch even if you’re not in a position to tap the screen.

But what I like most about the gesture is that it’s also a shortcut for jumping back to the watch face. For example, when a Live Activity is automatically showing up in the Smart Stack, a quick flick of the wrist hides the stack. Or let’s say you’re configuring a feature in the Settings app that’s buried a few levels deep. You don’t need to repeatedly tap the back (<) button — just flick your wrist.

Make the Smart Stack work for you

The Smart Stack is a place to access quick information that might not fit into what Apple calls a «complication» (the things on the watch face other than the time itself, such as your Activity rings or the current outside temperature). When viewing the clock face, turn the digital crown clockwise or swipe from the bottom of the screen to view a series of tiles that show information such as the weather or suggested photo memories. This turns out to be a great spot for accessing features when you’re using a minimal watch face that has no complications.

Choose which Live Activities appear automatically

The Smart Stack is also where Live Activities appear: If you order a food delivery, for example, the status of the order appears as a tile in the Smart Stack (and on the iPhone lock screen). And because it’s a timely activity, the Smart Stack becomes the main view instead of the watch face.

Some people find that too intrusive. To disable it, on your watch open the Settings app, go to Smart Stack > Live Activities and turn off the Auto-Launch Live Activities option. You can also turn off Allow Live Activities in the same screen if you don’t want them disrupting your watch experience.

Apple’s apps that use Live Activities are listed there if you want to configure the setting per app, such as making active timers appear but not media apps such as Music. For third-party apps, open the Watch app on your iPhone, tap Smart Stack and find the settings there.

Add and pin favorite widgets in the Smart Stack

When the Smart Stack first appeared, its usefulness seemed hit or miss. Since then, Apple seems to have improved the algorithms that determine which widgets appear — instead of it being an annoyance, I find it does a good job of showing me information in context. But you can also pin widgets that will show up every time you open the stack.

For example, I use 10-minute timers for a range of things. Instead of opening the Timers app (via the App list or a complication), I added a single 10-minute timer to the Smart Stack. Here’s how:

  1. View the Smart Stack by turning the Digital Crown or swiping from the bottom of the screen.
  2. Tap the Edit button at the bottom of the stack. (In WatchOS 11, touch and hold the screen to enter the edit mode.)
  3. Tap the + button and scroll to the app you want to include (Timers, in this example).
  4. Tap a tile to add it to the stack; for Timers, there’s a Set Timer 10 minutes option.
  5. If you want it to appear higher or lower in the stack order, drag it up or down.
  6. Tap the checkmark button to accept the change.

The widget appears in the stack but it may get pushed down in favor of other widgets the watch thinks should have priority. In that case, you can pin it to the top of the list: While editing, tap the yellow Pin button. That moves it up but Live Activities can still take precedence.

Use the watch as a flashlight

You’ve probably used the flashlight feature of your phone dozens of times but did you know the Apple Watch can also be a flashlight? Instead of a dedicated LED (which phones also use as a camera flash), the watch’s full screen becomes the light emitter. It’s not as bright as the iPhone’s, nor can you adjust the beam width, but it’s perfectly adequate for moving around in the dark when you don’t want to disturb someone sleeping.

To activate the flashlight, press the side button to view Control Center and then tap the Flashlight button. That makes the entire screen white — turn the Digital Crown to adjust the brightness. It even starts dimmed for a couple of seconds to give you a chance to direct the light away so it doesn’t fry your eyes.

The flashlight also has two other modes: Swipe left to make the white screen flash on a regular cadence or swipe again to make the screen bright red. The flashing version can be especially helpful when you’re walking or running at night to make yourself more visible to vehicles.

Press the Digital Crown to turn off the Flashlight and return to the clock face.

Pause your Exercise rings if you’re traveling or ill

Closing your exercise, movement and standing rings can be great motivation for being more active. Sometimes, though, your body has other plans. Until WatchOS 11, if you became ill or needed to be on a long-haul trip, any streak of closing those rings that you built up would be dashed.

Now, the watch is more forgiving (and practical), letting you pause your rings without disrupting the streak. Open the Activity app and tap the Weekly Summary button in the top-left corner. Scroll all the way to the bottom (take a moment to admire your progress) and tap the Pause Rings button. Or, if you don’t need that extra validation, tap the middle of the rings and then tap Pause Rings. You can choose to pause them for today, until next week or month, or set a custom number of days.

When you’re ready to get back into your activities, go to the same location and tap Resume Rings.

Bypass the countdown to start a workout

Many workouts start with a three-second countdown to prep you to be ready to go. That’s fine and all, but usually when I’m doing an Outdoor Walk workout, for example, my feet are already on the move.

Instead of losing those steps, tap the countdown once to bypass it and get right to the calorie burn.

How to force-quit an app (and why you’d want to)

Don’t forget, the Apple Watch is a small computer on your wrist and every computer will have glitches. Every once in a while, for instance, an app may freeze or behave erratically.

On a Mac or iPhone, it’s easy to force a recalcitrant app to quit and restart, but it’s not as apparent on the Apple Watch. Here’s how:

  1. Double-press the Digital Crown to bring up the list of recent apps.
  2. Scroll to the one you want to quit by turning the crown or dragging with your finger.
  3. Swipe left on the app until you see a large red X button.
  4. Tap the X button to force-quit the app.

Keep in mind this is only for times when an app has actually crashed — as on the iPhone, there’s no benefit to manually quitting apps.

These are some of my favorite Apple Watch tips, but there’s a lot more to the popular smartwatch. Be sure to also check out why the Apple Watch SE 3 could be the sleeper hit of this year’s lineup, and Vanessa Hand Orellana’s visit to the labs where Apple tests how the watches communicate.

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