Technologies
Moderna booster update: How much does it protect against omicron and for how long?
Research shows that mRNA vaccine boosters can defend against the omicron variant. However, one new study finds that protection decreases after 10 weeks.
New research from Denmark and the UK this week demonstrates that mRNA boosters — like Moderna’s and Pfizer’s — offer significant protection against the new omicron variant of COVID-19. However, data from the UK on Friday indicates that booster protection starts to decrease notably after 10 weeks.
In a technical briefing released Friday, the UK Health Security Agency announced that the Oxford/AstraZeneca, Pfizer/BioNTech and Moderna vaccines all protect against omicron less than they did against delta, and that protection from boosters wanes in time. Booster effectiveness generally decreased from 60% to 70% protection at two to four weeks after the shot, down to 35% to 45% at 10 weeks, depending on the combination of vaccines administered.
The UK report also adds weight to the hope that omicron infections are less severe than with the delta variant, noting that the risk of hospitalization from omicron is about three-fifths of that from delta.
In a report published Wednesday on the preprint site Medrxiv, scientists at Copenhagen’s Statens Serum Institut examined health records of 3 million Danes taken between Nov. 20 and Dec. 12. They found vaccine effectiveness among seniors 60 and older who had received a booster dose 14 to 44 days earlier averaged 54.6%, according to Reuters. (That’s comparable to the rate found shortly after receiving one shot of the Pfizer vaccine, which quickly wanes.)
Their research hasn’t been peer-reviewed yet, but it follows preliminary data from Monday indicating Moderna’s half-dose COVID booster shot can raise antibody levels against omicron 37 fold. Moderna President Stephen Hoge said during a conference call that the lab results were “reassuring” and put booster recipients “comfortably” above the level of a breakthrough risk.
Moderna also indicated a potential double dose of the booster, 100 micrograms versus 50 micrograms, would increase omicron-neutralizing antibodies “approximately 83-fold higher than pre-boost levels.”
Omicron has quickly become the dominant strain in the US, accounting for nearly 75% of new COVID-19 cases. While it appears able to evade some of the defenses offered by two doses of the Pfizer and Moderna vaccines, boosters offer some protection against infection and are highly effective in preventing serious illness.
“The good news is when you boost someone, [protection] goes right back up,” Dr. Anthony Fauci, chief medical adviser to President Joe Biden, said on CNN last week.
On Dec. 16, a CDC advisory committee recommended Moderna’s Spikevax and Pfizer-BioNTECH’s Comirnaty, both mRNA vaccines, over Johnson & Johnson’s one-jab carrier, or virus vector, vaccine.
According to Our World in Data, the US averaged about 840,000 booster shots per day for the week ending Dec. 17, and more than 64 million Americans have been boosted since Aug. 13. The increased focus on boosters comes as the omicron variant forces the CDC, health officials and organizations to reconsider what it means to be “fully vaccinated.” President Biden recently announced new plans — including “free” at-home COVID-19 test kits and stricter rules for international travelers — to protect Americans from the surging omicron variant.
The CDC urges anyone 18 years or older to get a booster six months after their second dose of Moderna or Pfizer (and anyone 16 or 17 years old to get a booster six months after their second dose of Pfizer).
So far, the vaccines have proven highly effective in preventing serious reactions and death from COVID-19. People who are unvaccinated are 10 times more likely to be hospitalized if infected. With the federal vaccine mandate expected to start next month, the Biden administration expects even more Americans to get the jab. The government has also ordered 13 million courses of antiviral drugs in anticipation of higher caseloads this winter.
Here’s what you need to know about the Moderna booster, including doses, side effects and how to get a free ride. to your vaccination appointment. For even more details, here’s the latest on COVID-19 vaccines for kids, how you can soon get a free COVID-19 test kit and what to know about breakthrough infections.
How effective is the Moderna booster against the omicron variant?
On Monday, Moderna’s Hoge said early lab research shows the pharmaceutical company’s COVID-19vaccine booster provides “good protection against the omicronvariant” by raising antibody levels approximately 37 fold. Forcomparison, Pfizer said earlier this month its booster raises antibody levels 25 fold,creating “robust protection” and offering “a sufficientlevel of protection” against omicron.
Studies of omicron variant infections in the US appear to support the concern about weakened protection for those who are fully vaccinated with two doses of the Moderna and Pfizer vaccines or one of Johnson & Johnson’s, but did not get a booster yet. Dr. Rochelle P. Walensky, CDC director, said Dec. 10 that80% of the first confirmed US cases with the mutated strain had been in patients who were fullyvaccinated.
Is Moderna working on additional COVID vaccine boosters?
On Monday, Moderna president Stephen Hoge said the company’s current 50-microgram COVID booster gives “quite respectable” protection. The company is continuing to study an omicron-specific vaccine and a multivalent one that could protect against other variants, including the alpha and delta strains, in case either is needed.
The company said it is also studying a 100-microgram version of its current vaccine booster, which appears to raise antibody protection 83 fold. Hoge said Moderna could have new versions of its vaccine ready early in 2022 but is not planning to ask the CDC and FDA to amend its booster authorization for the 100-microgram trial version of its booster.
Will we need an annual COVID booster shot?
With vaccines appearing to offer waning protectionand a continuing evolution of COVID variants, Hoge said we will most likely needseasonal boosters, much like we do with the flu, at least toprotect those at high risk of infection. The new research from UKHSA strongly indicates reduced protection from vaccine boosters after 10 weeks.
The CDC updated its guidanceto indicate that, starting in 2022, some immunocompromised people will be able to get afourth COVID-19 booster shot.
When is it time to get a COVID-19 vaccine booster shot?
If you got Moderna or Pfizer jab, you’re eligible for a booster six months after the date of the second shot listed on yourvaccination card. Two months after the Johnson & Johnson vaccine is the time for a booster (more below).
The CDC and other health authorities are now urging people to get boosters as soon as they’re eligible, to keep the immune response againstomicron, delta and other coronavirus variants of concern as strong as possible.
On Dec. 2, President Biden outlined a plan forMedicare to contact the 64 million people it serves and for AARP toreach out to its 38 million members about getting a booster shot. Pharmacies like Walgreens,CVS and Rite Aid are contacting customers who got a vaccine attheir stores when it’s time to schedule a booster.
Should people who are pregnant get a booster shot?
The COVID-19 booster recommendations apply to all people 18 years and older, including those who are pregnant. The CDC urges pregnant people to get a COVID-19 vaccine, a booster is half a full vaccine dose.
“People who are pregnant or recently pregnant are more likely to get severely ill with COVID-19 compared with people who are not pregnant,” the CDC says on its website.
While there is no evidence that getting vaccinated decreases fertility in women or men, a recent study also linked COVID-19 infection in pregnant people to a higher risk of stillbirth.
Is the Moderna booster shot a third dose of the vaccine?
Booster shots of COVID-19 vaccines are currently half doses of the same vaccine used in the first two full shots. The goal is to top up the formula and reinforce the body’s immune response against the virus and its variants. While the first two shots of the Moderna vaccine were each 100 micrograms, the booster is a 50-microgram dose.
Moderna is also working on a combination shot that contains this year’s flu vaccine and its COVID-19 booster vaccine, but that’s not available right now.
How do I know which pharmacies have Moderna booster shots available?
Boosters are available at roughly 80,000 locations across the US, including over 40,000 pharmacies. Some 90% of Americans have a vaccine site within five miles of where they live.
A free service backed by the CDC sends you information on vaccine sites when you text your ZIP code to this number: 438829. The response will show you COVID-19 vaccine locations in your area, along with the brands they carry for certain age groups, for instance, Moderna 18+. This can save you from having to call around, or show up to an appointment to find that your booster of choice isn’t available. The text message also offers a shortcut to make your appointment right from your phone screen.
In addition, you can check Vaccines.gov to see which vaccines are available where, or call 800-232-0233 for additional vaccine information.
How can I get a free ride to get my booster shot?
Lyft and Uber are offering free rides for some people who need them. An easy way to access those links for more information is through the text feature above. You can also go to Lyft.com/vax or call Uber at 855-921-0033.
Who can get a Moderna booster shot right now?
On Nov. 19, all US adults 18 and older became eligible to receive COVID-19 booster shots if it’s been at least six months since they’ve received a second dose of either the Moderna or Pfizer vaccine. Those who received the Johnson & Johnson vaccine are eligible for a booster dose after two months. Adults are encouraged to get whatever booster dose is available, even if that means mixing and matching vaccine boosters (more below).
What are the side effects of Moderna’s booster?
Moderna says possible side effects for its booster shot are similar to those from the two primary doses, and include pain or swelling at the injection site, as well as fatigue, muscle pain, headache, fever, chills and nausea.
The good news is, according to the CDC, those who got the Moderna booster dose reported far fewer reactions than they did after the second dose of the vaccine.
Is it safe to mix and match vaccine and booster brands?
Yes. The US Food and Drug Administration has authorized mixing COVID-19 boosters, which in the US means Moderna and Pfizer. Any adult eligible for a booster can get any of the available brands of coronavirus vaccines. If you initially received Johnson & Johnson and it’s been two months or longer since you received the initial dose, you’ll be able to get the Moderna or Pfizer booster. If you received Moderna or Pfizer for your first two shots, you could pick any authorized vaccine available to you, if you qualify and it’s been six months or longer since your second shot.
In its study, the CDC found 95% of those who got Moderna for the first round of vaccine shots chose Moderna for the booster dose.
Is the Moderna COVID-19 booster shot still free?
All booster shots will be free, regardless of immigration or health insurance status. However, depending on where you get your booster shot — for example, at a local pharmacy — you may be asked to provide your insurance card information, including your name, date of birth and membership number. But ou will not be charged for your COVID-19 vaccine or booster shot.
What does the Moderna booster shot do?
As the vaccine’s effectiveness decreases over time, a COVID-19 booster shot — whether from Moderna, Pfizer or Johnson & Johnson — recharges your body’s immune response and guards against a breakthrough infection.
Recent studies of the Pfizer and AstraZeneca vaccines show that their effectiveness can begin to wane after six months. Moderna said early data suggests that those who received the Moderna vaccine in 2020 are showing a higher rate of breakthrough COVID-19 infections than those vaccinated this year, suggesting the need for a booster to maintain high levels of protection.
For more on coronavirus treatments and vaccines, here’s what we know about monoclonal antibody treatments, the new federal vaccine mandates and why some people may not want the shot.
The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.
Technologies
U.S. diesel price tops $6 per gallon, a record high as Ukraine and Iran wars ripple through economy
U.S. diesel prices hit their highest level ever as fuel supply disruption stemming from the Ukraine and Iran wars lifts transportation costs.
U.S. diesel prices hit $6 per gallon on Friday for the first time ever, as fuel supply disruptions triggered by the Ukraine and Iran wars raises transportation costs across the entire economy.
Truckers and farmers are paying about 63% more to fill up their semis and tractors than they did at this time last year, according to data from AAA. The average price nationwide is now about $6.06 per gallon.
Prices are even higher in California, the biggest agriculture state in the U.S., at $7.98 per gallon.
Fuel costs are rising as crude oil prices have surged in response to a sharp escalation in fighting between the U.S. and Iran this month. U.S. crude oil futures topped $100 per barrel on Thursday for the first time since May. The contract has gained about 20% in September.
Diesel is the real lifeblood of the economy even though consumers tend to pay more attention to retail gasoline prices, said Bob McNally, president of Rapidan Energy, in an interview with CNBC’s “The Exchange” on Tuesday.
Higher diesel prices are passed down to consumers in what they pay for food, consumer goods and energy. Diesel fuels the trucks, trains and ships that bring goods to market. It powers the machinery that farmers use to plant and harvest food. And it heats homes and generates electricity in some cases.
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“It’s the more insidious, more costly, and more impactful fuel,” McNally said. “As we climb higher, it is a real concern.”
Diesel prices at these levels will be a “silent killer” for the economy, said Patrick De Haan, head of petroleum analysis at GasBuddy, in an interview with CNBC’s “Power Lunch” Tuesday.
Gasoline prices, meanwhile, have never been this high this late in the year, De Haan said. Prices at the pump hit a Labor Day record of $4.15 per gallon earlier this week. Americans are spending about $700 million more per day on gas and diesel than they did a year ago, the analyst said.
“There’s sticker shock there for consumers,” De Haan said.
Fuel costs are rising as the Iran and Ukraine wars have disrupted global supplies. Kyiv has pounded Russian refineries, forcing Moscow to ban diesel exports. Iran and its militant Houthi allies in Yemen have also hit the refineries of U.S. Gulf allies. Fuel exports through the Strait of Hormuz are constrained due to the Iranian attacks on tankers.
The wars in Eastern Europe and the Middle East have shut down refineries with about 5 million barrels per day of capacity, said Valero Chief Operating Officer Gary Simmons on the U.S. refiner’s July 30 earnings call.
The world has lost nearly 8% of its diesel supply with little spare refining capacity available to make up the shortfall, said Andy Lipow, president of Lipow Oil Associates, in a Wednesday note.
Rising diesel prices pose an “enormous challenge” for the Trump administration, said Helima Croft, head of global commodity strategy at RBC Capital Markets, in a Sept. 4 interview with CNBC’s “Power Lunch.”
“U.S. refineries are running at 98% utilization rates — there is just no spare capacity,” Croft said.
Technologies
Buffett’s confidence in troubled decade-old acquisition finally pays off
Warren Buffett has said he paid too much for Precision Castparts in 2016. Now its complex metal castings are in high demand.
(This is the Warren Buffett Watch newsletter, news and analysis on all things Warren Buffett and Berkshire Hathaway. You can sign up here to receive it every Friday evening in your inbox.)
Buffett’s confidence in troubled decade-old acquisition finally pays off
Six years ago, when Berkshire Hathaway took an $11 billion write-down of its $37.2 billion 2016 acquisition of Precision Castparts, Warren Buffett wrote in his annual letter to shareholders he had paid “too much” for the company, which makes “complex metal components and products.”
While it was a “fine company – the best in its business,” he had been “simply too optimistic” about its profit potential, a “miscalculation … laid bare” by the enormous downturn for the aerospace industry, Precision Castparts’ largest customers, amid the Covid pandemic.
In a CNBC interview when the deal was first announced, Buffett admitted it was “a very high multiple for us to pay,” but told shareholders at the 2016 meeting he had great confidence in Mark Donegan, the company’s CEO, both then and now, and the company’s long-term profit outlook.
It’s taken longer than he planned, but Buffett’s purchase is now looking pretty good.
As Reuters puts it, there is currently a shortage of the “complex” products Precision Castparts makes that are essential for engine turbine blades.
They’re also used in natural gas turbines, which are in demand to produce energy for artificial intelligence data centers.
This week, GE Aerospace announced it would pay $11.75 billion to acquire Consolidated Precision Products, one of the few companies that competes against Precision Castparts.
Barron’s calls that “pricey” at 26 times projected 2027 earnings before interest, taxes, depreciation, and amortization.
Using the same multiple, Barron’s estimates Precision Castparts is worth around $100 billion. That’s well above the potential value of $60 billion to $75 billion it cited in an article last month that said the unit “probably has become one of the more valuable divisions” of Berkshire.
It’s also nearly three times the 2016 purchase price.
In the Barron’s piece, Andrew Bary said Berkshire, and its share price, aren’t “getting much credit” for the subsidiary’s rising value, in part because CEO Greg Abel, like Buffett, doesn’t do analyst conference calls or investor events that could draw attention to the unit’s performance.
His recommendation: “Without Warren Buffett at the helm, Berkshire may have to start telling its story if it wants to attract a new generation of investors. This year’s trading action suggests that something may need to change.”
Berkshire bounces a bit as Wall Street sells off
Berkshire Hathaway shares managed a modest gain this week even as Wall Street’s major averages declined, a small departure from the 2026 “trading action” Bary cites.
Both the Class A and Class B shares gained almost 0.9% while the S&P 500 fell by 0.8%.
Until Friday’s bounce, that benchmark index, along with the Dow Industrials and the Nasdaq Composite, had dropped four days in a row as oil and bond yields moved higher.
Even with this week’s outperformance, Berkshire’s B shares still trail the S&P 500 by more than 10 percentage points so far this year.
Nebraska candidate moves to replace ad that included Buffett’s image
The campaign team for the Republican running in Nebraska’s 2nd Congressional District accelerated the deployment of a new campaign ad after Susie Buffett complained about a previous commercial that briefly included an image of her father, Warren Buffett.
In the ad, a picture of Buffett and his name appear on screen for roughly two seconds as candidate Brinker Harding says, “Here in Omaha, we know a thing or two about the stock market, some more than others. But we do it without insider information.”
He then goes on to highlight his call for a ban on Congressional stock trading, saying some lawmakers “trade on secrets you’ll never know,” as they “get rich” while “we barely get by.”
In a report that led its 10 PM CT newscast Wednesday evening, ABC affiliate KETV in Omaha reported Susie Buffett had asked Harding on Sept. 2 to remove the ad.
She told the station, “I think it’s worth it to say that Warren did not give Brinker his permission to use his face or name in his ad.
“It implies that my dad endorses him. He did not have permission to use it.”
The KETV report quoted Harding as saying in a statement, “In Nebraska, we work hard and support each other, and we do it honestly. Warren Buffett exemplifies that, and that was the point of my ad.”
The report said Harding did not comment on whether the ad would be taken down but noted “it does look like new ads from his campaign are beginning to run on some stations.”
A Harding campaign spokesperson told me the campaign did not think its ad implied a Buffett endorsement, but to be respectful to the Buffett family, it responded to her concern by accelerating the rollout of its next planned ad by several days, although its effort was hampered by the Labor Day weekend.
The commercial now running does not show or mention Buffett.
BUFFETT & BERKSHIRE AROUND THE INTERNET
Some links may require a subscription:
– Best’s News and Research Service: 2026 Best’s Rankings: Berkshire Hathaway Takes DPW Top Spot Among Accident & Health Lines
– Financial Times: The day Warren Buffett saved Salomon Brothers
HIGHLIGHTS FROM CNBC’S BUFFETT ARCHIVE
The effects of 9/11 on Berkshire and the insurance industry (2002)
Warren Buffett shares his thoughts on the 9/11 attacks and explains how Berkshire’s insurance companies have started taking terrorism into account when writing policies.
AUDIENCE MEMBER: I know you lost a lot of money as a result of 9/11. But I would like to know how 9/11 changed your life and your investment strategy?
WARREN BUFFETT: It made everybody, I think, in the country aware, I mean, we’ve gone through world wars and all of that, and essentially felt quite protected within these borders.
And I have been quite worried about — Charlie can attest to — you know, the possibility, particularly of some kind of nuclear device in this country, by — probably more likely by terrorists than by some, at least, declared act of war by another state.
And 9/11 made everybody realize that as humans have not progressed, particularly, in terms of how they behave with each other over the years, they have progressed enormously in their ability to inflict damage on those they hate for one reason or another…
In terms of the business aspects of it, in your question, obviously the area at Berkshire that it effects most significantly, by miles, is insurance.
And prior to 9/11, even though we recognized that there could be huge monetary damages that flowed from the activities of what I would call deranged people, we hadn’t really written the contracts in such a way as to either get paid for taking that risk or to exclude the risk. In other words, we were throwing it in for nothing.
We had excluded risk for war. I mean, we knew that we’d seen what had happened in England in the 40s, and so we had taken account of something that some of us had seen with our own eyes, but we didn’t take account of something that we knew was possible, but we just hadn’t seen. And that’s, you know, that’s the human condition, to some degree.
Since September 11th, everybody in the insurance business recognizes that they had exposures that they weren’t charging for, and they either had to exclude those exposures or they had to charge for them.
We have written — first thing we had to do, of course, is we had lots of policies on the books that left us exposed to this, and most of those policies ran for a year, starting at different points. Those have run off to a great degree, but they’re not entirely run off.
The other thing we did was on new policies. We have sold a fair amount, quite a large amount, of terrorism insurance that excludes what we call NCB, nuclear, chemical, and biological, as well as fire following nuclear.
And, we can take a fair amount of exposure to that sort of terrorism, because it doesn’t — it won’t aggregate. It aggregated at the Twin Towers in a way that — World Trade Center — in a way that just about was as extreme as you could get for non-NCB-type activities.
I mean, that was a huge amount of damage done without nuclear, chemical, or biological.
But we can have tens of billions of dollars with NCB excluded throughout a greater New York area, or something, but we can’t have hundreds of billions of exposure that would be exposed, say, to, nuclear activities, because there an act or two, or three, coordinated, could cause damage that would destroy the insurance industry.
And if we had coverage on that, it would destroy us as well.
BERKSHIRE STOCK WATCH
Four weeks
Twelve months
BRK.A stock price: $766,000.00
BRK.B stock price: $510.37
BRK.B P/E (TTM): 12.83
Berkshire Cash as of June 30: $365.5 billion (Down 8.0% from March 31)
Excluding Rail Cash and Subtracting T-Bills Payable: $359.2 billion (Down 3.8% from March 31)
Berkshire repurchased $4.5 billion of its shares in Q2 2026.
BERKSHIRE’S TOP EQUITY HOLDINGS – Sep. 11, 2026
Berkshire’s top holdings of disclosed publicly traded stocks in the U.S. and Japan, by market value, based on the latest closing prices.
Holdings are as of June 30, 2026, as reported in Berkshire Hathaway’s 13F filing on August 14, 2026, except for:
– Mitsubishi, which is as of April 30, 2026
The full list of holdings and current market values is available from CNBC.com’s Berkshire Hathaway Portfolio Tracker.
QUESTIONS OR COMMENTS
Please send any questions or comments about the newsletter to me at alex.crippen@cnbc.com. (Sorry, but we don’t forward questions or comments to Buffett himself.)
If you aren’t already subscribed to this newsletter, you can sign up here.
Also, Buffett’s annual letters to shareholders are highly recommended reading. There are collected here on Berkshire’s website.
— Alex Crippen, Editor, Warren Buffett Watch
Technologies
Wall Street firm warns AI stock rally may be nearing its end: key reasons
Capital Economics says that while the S&P 500 may keep rising this year, the AI‑driven rally shows multiple bubble indicators and is expected to peak within months, with a projected decline to 6,500 by late 2027.
Various signs of a market bubble indicate that although the S&P 500’s rally can continue this year, its medium‑term outlook appears weak because the market has become overly frothy, according to Capital Economics.
James Reilly, senior market economist at Capital Economics, noted on Thursday that most indicators point to the AI equity rally being close to its end.
Since mid‑2023, Capital has been more optimistic than most about the stock market, viewing AI as a transformative technology.
The firm’s year‑end 2026 S&P 500 forecast has consistently exceeded consensus estimates.
Nevertheless, Capital maintains that the AI‑driven rally is a bubble destined to burst.
To identify a late‑stage bubble, Reilly examines eight metrics: valuations, earnings, index concentration, equity issuance, and foreign interest in U.S. stocks.
Several of these metrics are already at or near levels seen before past market peaks.
While earnings expectations appear aligned with a market top, measures such as volatility and leverage are somewhat less concerning.
Earnings are the most significant warning sign.
S&P 500 earnings growth expectations are hovering at levels only seen at the dot‑com bubble peak, and long‑term EPS forecasts have reached a record high.
Reilly argues that the tech sector’s heavy concentration of this growth means any weakness in tech earnings will heavily drag on the index.
Additional warning signals are also emerging.
Index concentration is approaching dot‑com era extremes, net equity issuance has turned positive, and foreign ownership of U.S. stocks is at a record level.
Reilly warns that another wave of IPOs and share sales could be especially significant, as past issuance booms have historically coincided with market peaks.
He adds that, based on history, the bubble’s end is likely just months away, not years.
Leverage measures are not yet alarming compared with other factors, though the analyst cautions they are moving in a concerning direction.
Volatility indicators resemble those of a mid‑stage bubble, but constituent‑level volatility is not as extreme as at the dot‑com bust’s end.
Reilly expects the S&P 500 to rise from roughly 7,650 now to about 8,250 by the end of 2026, but ultimately projects a decline to 6,500 by the end of 2027.
These projections imply an 8% gain this year and a 21% drop in 2027.
Most signs point to the AI equity rally being close to its conclusion, Capital Economics senior market economist James Reilly stated on Thursday in a note.
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