Technologies

Delta variant: Could COVID vaccine boosters be here sooner than we thought?

With breakthrough infections in fully vaccinated people, the debate is over whether booster shots are needed to protect against the highly contagious strain.

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

During the third week of July, the World Health Organization reported a 131% increase in new COVID cases in the US. With the delta variant of the coronavirus becoming the dominant strain, pharmaceutical giant Pfizer said it’s working on a booster shot for its COVID-19 vaccine. To prepare for the possibility, the US Centers for Disease Control and Prevention said it’s weighing a third shot for immune-compromised people.

In a July 8 press release, Pfizer said a third shot of its vaccine would enhance the immunity of those who’ve already received the first two vaccine shots. In addition to creating a booster for its existing vaccine, the drugmaker said it would formulate a new version of its COVID-19 vaccine to target the delta variant. The CDC and the Food and Drug Administration responded with a joint statement the same day saying that fully vaccinated Americans «do not need a booster shot at this time.»

But that was all before the CDC’s most recent internal document confirmed in late July that vaccinated people can both contract the highly contagious delta variant and easily spread it. Those recent findings were behind the CDC’s shift in its mask guidance, which now recommends indoor mask use for everyone in areas with high transmission rates. The debate over mask use and vaccine boosters underscores how scientists and other health experts continue to grapple with the uncertainties of COVID-19.

Here’s what we know about Pfizer’s plans for a booster, and why the CDC and FDA caution against it, at least for now.

What are Pfizer’s plans for a COVID-19 booster shot?

Along with Moderna, Pfizer’s current two-dose vaccine provides effective protection against all known variants of COVID-19, including the delta variant. Studies have shown the Pfizer vaccine to be over 90% effective against the virus. But Pfizer also said its own research showed a third booster of its current vaccine increased antibody levels five to 10 times higher over its two-dose shots. The company noted its results have not been published or peer-reviewed.

Pfizer said it believes the level of protection the two doses of its vaccine provide can decrease over time, and a third booster dose may be needed «within six to 12 months» after a person is fully vaccinated. To prepare for the booster, Pfizer is testing both the effectiveness of a third dose of its current vaccine and working on an updated version targeting the delta variant. Pfizer said it would begin clinical trials on the booster this month as it seeks approval from government regulators for a third dose.

The company says a third shot given at least six months after the second shot in its original vaccine series would enhance protection against the delta variant, which has been known to infect fully vaccinated people.

What are the CDC and FDA saying in response?

«People who are fully vaccinated are protected from severe disease and death, including from the variants currently circulating in the country such as Delta,» the CDC and FDA said in a July 8 joint statement, without naming Pfizer. The government agencies emphasized the need for all eligible people to receive full doses of one of the approved vaccines, all of which are free.

The CDC and FDA said the question of a booster requires extensive scientific data and doesn’t depend on the input from pharmaceutical companies alone. «Virtually all COVID-19 hospitalizations and deaths are among those who are unvaccinated,» the statement mentioned, adding that the agencies will approve booster doses «if and when the science demonstrates that they are needed.»

According to a July 23 article in The New York Times, there is a growing consensus among Biden administration health officials that older individuals and those with compromised immune systems may, in fact, need a third shot. The same article notes that the CDC is exploring options to administer third doses even prior to authorization.

Is Moderna also planning to develop a booster shot?

While scientists and public health officials continue to study if those who are fully vaccinated will need a booster shot, Moderna said — along with Pfizer — it is moving ahead and exploring the need for a third shot.

Would the booster shot be free?

The current one-dose vaccine shot from Johnson & Johnson and two-dose versions from Moderna and Pfizer are free to anyone who wants to get vaccinated. According to the Biden administration, COVID-19 booster shots will also be free, if and when they’re approved.

Is it a good idea to mix and match COVID vaccines?

The CDC doesn’t recommend mixing and matching vaccines from the different makers, saying it hasn’t evaluated the effectiveness of mixing vaccine doses and that the «vaccines are not interchangeable.»

However, other global health agencies and countries are testing administered vaccines from two different manufacturers. In England, for example, a recent study found that those who received a first dose of the AstraZeneca vaccine and a second of Pfizer had a higher immune response than those who received two doses of the AstraZeneca vaccine.

While we wait to see how the situation develops, here’s what we know about the delta variant, more about COVID-19 boosters and if you need to continue to wear a mask.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

Today’s NYT Connections Hints, Answers and Help for May 24, #713

Hints and answers for Connections for May 24, #713.

Looking for the most recent Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles.

Today’s Connections puzzle has a fun variety of categories. The purple one appeals to my English major heart. Read on for clues and today’s Connections answers.

The Times now has a Connections Bot, like the one for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. Players who are registered with the Times Games section can now nerd out by following their progress, including number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak.

Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time

Hints for today’s Connections groups

Here are four hints for the groupings in today’s Connections puzzle, ranked from the easiest yellow group, to the tough (and sometimes bizarre) purple group.

Yellow group hint: Goo-goo.

Green group hint: Not shirts.

Blue group hint: City that never sleeps.

Purple group hint: Acclaimed writers.

Answers for today’s Connections groups

Yellow group: Baby gear.

Green group: Kinds of pants minus «s.»

Blue group: New York sports team members.

Purple group: Black women authors.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections answers?

The yellow words in today’s Connections

The theme is baby gear. The four answers are bib, bottle, monitor and stroller.

The green words in today’s Connections

The theme is kinds of pants minus «s.» The four answers are capri, jean, jogger and slack.

The blue words in today’s Connections

The theme is New York sports team members. The four answers are Jet, Met, Net and Ranger.

The purple words in today’s Connections

The theme is black women authors. The four answers are Butler, Gay, Hooks and Walker.

Technologies

Today’s NYT Mini Crossword Answers for Tuesday, May 20

Here are the answers for The New York Times Mini Crossword for May 20.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Today’s NYT Mini Crossword is a fun one, and now I’m singing the song from 1-Across in my head. Need some help with today’s Mini Crossword? Read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

The Mini Crossword is just one of many games in the Times’ games collection. If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get at those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: «Pink ___ Club» (Chappell Roan hit)
Answer: PONY

5A clue: Instrument that might be made with a comb and wax paper
Answer: KAZOO

6A clue: How bedtime stories are often read
Answer: ALOUD

7A clue: On edge
Answer: TENSE

8A clue: Short Instagram video
Answer: REEL

Mini down clues and answers

1D clue: Less colorful
Answer: PALER

2D clue: Layer of the upper atmosphere
Answer: OZONE

3D clue: Totally pointless
Answer: NOUSE

4D clue: Hit a high note in a high place, perhaps
Answer: YODEL

5D clue: Kit ___ bar
Answer: KAT

How to play more Mini Crosswords

The New York Times Games section offers a large number of online games, but only some of them are free for all to play. You can play the current day’s Mini Crossword for free, but you’ll need a subscription to the Times Games section to play older puzzles from the archives.

Technologies

Want to Speak to Dolphins? Researchers Won $100,000 AI Prize Studying Their Whistling

The scientists studied a bottlenose dolphin community in Sarasota, Florida, uncovering evidence of language-like communications.

If any dolphins are reading this: hello!

A team of scientists studying a community of Florida dolphins has been awarded the first $100,000 Coller Dolittle Challenge prize, set up to award research in interspecies communication algorithms.

The US-based team, led by Laela Sayigh of the Woods Hole Oceanographic Institution, found that a type of whistle that dolphins employ is used as an alarm. Another whistle they studied is used by dolphins to respond to unexpected or unfamiliar situations. The team used non-invasive hydrophones to perform the research, which provides evidence that dolphins may be using whistles like words, shared with multiple members of their communities.

Capturing the sounds is just the beginning. Researchers will use AI to continue deciphering the whistles to try to find more patterns.

«The main thing stopping us cracking the code of animal communication is a lack of data. Think of the 1 trillion words needed to train a large language model like ChatGPT. We don’t have anything like this for other animals,» said Jonathan Birch, a professor at the London School of Economics and Politics and one of the judges for the prize.

«That’s why we need programs like the Sarasota Dolphin Research Program, which has built up an extraordinary library of dolphin whistles over 40 years. The cumulative result of all that work is that Laela Sayigh and her team can now use deep learning to analyse the whistles and perhaps, one day, crack the code,» he said.

The award was part of a ceremony honoring the work of four teams from across the world. In addition to the dolphin project, researchers studied ways in which nightingales, marmoset monkeys and cuttlefish communicate.

The challenge is a collaboration between the Jeremy Coller Foundation and Tel Aviv University. Submissions for next year open up in August.

Dolphins are just the beginning

Researching animals and trying to learn the secrets of their communication is nothing new; but AI is speeding up the creation of larger and lager datasets.

«Breakthroughs are inevitable,» says Kate Zacarian, CEO and co-founder of Earth Species Project, a California-based nonprofit that also works in breaking down language barriers with the animal world.

«Just as AI has revolutionized the fields of medicine and material science, we see a similar opportunity to bring those advances to the study of animal communication and empower researchers in this space with entirely new capabilities,» Zacarian said.

Zacarian applauded Sayigh’s team and their win and said it will help bring broader recognition to the study of non-human animal communication. It could also bring more attention to ways that AI can change the nature of this type of research.
«The AI systems aren’t just faster — they allow for entirely new types of inquiry,» she said. «We’re moving from decoding isolated signals to exploring communication as a rich, dynamic, and structure phenomenon — whish is a task that’s simply too big for our human brains, but possible for large-scale AI models.»

Earth Species recently released an open-source large audio language model for analyzing animal sounds called NatureLM-audio. The organization is currently working with biologists and ethologists to study species including carrion crows, orcas, jumping spiders and others and plans to release some of their findings later this year, Zacarian said.