Technologies

Doctors Transplant Genetically Modified Pig’s Heart Into Human in Medical First

The milestone operation shines a hopeful light for the long ledger of patients awaiting organ transplants.

Last month, an ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time, marking a historic moment for medicine. About five weeks post-surgery, the 57-year-old organ recipient, David Bennett, was still doing well.

«His heart function looks great, his blood pressure looks very good, and in fact, he’s on medicine to reduce his blood pressure. That’s how good it is right now,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the heart, said in an update on Feb 11.

On Feb. 14, medical staff caring for Bennett even released an inspiring clip of him watching this year’s Super Bowl and singing «America the Beautiful» as Jhené Aiko performed her rendition at the game. While the team continues to monitor Bennett closely, particularly due to reported preoperative kidney setbacks that persisted after the procedure, Griffith offered encouraging words: «Beyond that, I’d say all thumbs are up.»

This medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis. «There are simply not enough donor human hearts available to meet the long list of potential recipients,» Griffith, who’s also a professor in transplant surgery at the university, said in a statement.

«We are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,» Griffith said. According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant, and more than 17 patients die each day while still on the waitlist.

Leading up to his surgery, Bennett was one of those anxious patients on hold. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, nonhuman-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

«We’ve been asked how we would define success,» Griffith said in the team’s most recent update, underlining his cautious hope. «I think we’ve surpassed, in many measures, what we expected.»

Technologies

Stuck in a Coffee Rut? ChatGPT Can Now Plan Your Next Starbucks Order

Don’t be surprised if the chatbot suggests mixing espresso with lemonade.

If you like getting your daily cup of coffee from Starbucks, you’ll now be able to consult with ChatGPT for your next beverage. Starbucks said on Wednesday that a new Starbucks app in ChatGPT, now in beta, will help you figure out your next order based on your mood or craving in the moment.

Although you won’t be able to order your Starbucks coffee directly through the ChatGPT app, it will suggest drinks and menu items you may enjoy, then direct you to the Starbucks app or website to complete your order.

OpenAI has added a host of other apps you can interact with in ChatGPT since announcing the functionality last year. You can do everything from browsing home listings to designing playlists without leaving the chatbot interface.

You’ll be able to use prompts like, «@Starbucks, I want something bright to start my morning,» or upload an image to describe your mood and location. Once the menu suggestion appears in ChatGPT, you can start the order through the chatbot and then complete it in the Starbucks app or online.

Paul Riedel, senior vice president of digital and loyalty at Starbucks, said in a statement that Starbucks noticed customers weren’t always starting off by looking at the menu. «They’re starting with a feeling,» he said. «We wanted to meet customers right in that moment of inspiration and make it easier than ever to find a drink that fits.»

Starbucks said interacting with ChatGPT lets you personalize your order more and discover menu options you never considered before.

(Disclosure: Ziff Davis, CNET’s parent company, in 2025 filed a lawsuit against OpenAI, alleging it infringed Ziff Davis copyrights in training and operating its AI systems.)

When I tried out the new feature, I asked it about the oddest beverage combinations you can get at Starbucks. One interesting combo ChatGPT came up with was espresso with lemonade. The AI described another drink as «basically liquid dessert soup,» if that’s more up your alley.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for April 16, #570

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for April 16 No. 570.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition is a fun one, especially if you enjoy unusual team names. If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Put your glasses on for this.

Green group hint: Hoops home.

Blue group hint: The minors.

Purple group hint: Hidden hoops word.

Answers for today’s Connections: Sports Edition groups

Yellow group: Look at.

Green group: Seen at an NBA court.

Blue group: Double-A baseball teams.

Purple group: Starts with a WNBA team.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is look at. The four answers are observe, spectate, view and watch.

The green words in today’s Connections

The theme is seen at an NBA court. The four answers are benches, half-court logo, scorer’s table and shot clock.

The blue words in today’s Connections

The theme is double-A baseball teams. The four answers are Biscuits, Drillers, Trash Pandas and Wind Surge.

The purple words in today’s Connections

The theme is starts with a WNBA team. The four answers are dreamy, firefly, Skype and sundial.

Technologies

Today’s NYT Mini Crossword Answers for Thursday, April 16

Here are the answers for The New York Times Mini Crossword for April 16.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Need some help with today’s Mini Crossword? It’s pretty simple, but 1-Across is a bit tricky. Read on for all the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.