Technologies

Surgeons transplant pig heart into human for first time

A medical milestone involving an animal’s genetically modified organ shines a hopeful light for the long ledger of patients awaiting organ transplants.

An ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time last week, marking a historic moment for medicine. As of Monday, three days after the surgery, the 57-year-old organ recipient, David Bennett, was reportedly still doing well.

While the team will monitor Bennett closely in coming weeks to ensure long-term benefits from the procedure, their medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis.

«There are simply not enough donor human hearts available to meet the long list of potential recipients,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the pig heart, said in a statement. He’s also a professor in transplant surgery at the medical school.

«We are proceeding cautiously,» Griffith added, «but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future.» According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant and more than 17 patients die each day before making their way to the top of the waitlist.

Leading up to his surgery, Bennett’s story unfortunately mimicked those of the many, many patients awaiting transplants. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, non-human-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

Technologies

Today’s NYT Mini Crossword Answers for Saturday, July 5

Here are the answers for The New York Times Mini Crossword for July 5.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Need some help with today’s Mini Crossword? 14-Across was a real doozy. I hadn’t ever heard anyone use that word to mean what the NYT says it means, even though I do recognize it as part of a related word. Whether this clue or another one has stumped you today, read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

The Mini Crossword is just one of many games in the Times’ games collection. If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: Blasts with unwanted messages
Answer: SPAMS

6A clue: Orderly assortment
Answer: ARRAY

7A clue: Its state mammal is the bison, and its state sport is rodeo
Answer: WYOMING

9A clue: «Let me think …»
Answer: HMM

10A clue: Hawaii’s Mauna ___
Answer: LOA

11A clue: Shanghai-born N.B.A. Hall-of-Famer who stood at 7’6″
Answer: YAOMING

13A clue: Emotionless, as a gaze
Answer: STONY

14A clue: Another name for an earthquake
Answer: SEISM

Mini down clues and answers

1D clue: Lead a Catholic ceremony
Answer: SAYMASS

2D clue: Hype up
Answer: PROMOTE

3D clue: Place for Popeye’s anchor tattoo
Answer: ARM

4D clue: Ballots cast from home
Answer: MAILINS

5D clue: Thesaurus listing
Answer: SYNONYM

7D clue: Alphabetically last of the «five W’s»
Answer: WHY

8D clue: Silly joke
Answer: GAG

12D clue: «Excusez-___!»
Answer: MOI

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for July 5, #285

Here are some hints and the answers for the NYT Connections: Sports Edition puzzle for July 5, No. 285.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition raised my confidence with a very easy yellow category. Then my guesses kind of fell apart. Need some help? Read on for hints and the answers.

Connections: Sports Edition is out of beta now, making its debut on Super Bowl Sunday, Feb. 9. That’s a sign that the game has earned enough loyal players that The Athletic, the subscription-based sports journalism site owned by the Times, will continue to publish it. It doesn’t show up in the NYT Games app but now appears in The Athletic’s own app. Or you can continue to play it free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: First question?

Green group hint: You win it.

Blue group hint: They call it football.

Purple group hint: Baseball accessories.

Answers for today’s Connections: Sports Edition groups

Yellow group: Setting for a news conference.

Green group: Starts of trophy names.

Blue group: England women’s soccer players.

Purple group: ____ base.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is setting for a news conference. The four answers are dais, lectern, podium and stage.

The green words in today’s Connections

The theme is starts of trophy names. The four answers are Ballon, Cy, Heisman and Stanley.

The blue words in today’s Connections

The theme is England women’s soccer players. The four answers are Bronze, Mead, Stanway and Williamson.

The purple words in today’s Connections

The theme is ____ base. The four answers are fan, first, stolen and third.

Technologies

Today’s Wordle Hints, Answer and Help for July 5, #1477

Here are hints and the answer for today’s Wordle for July 5, No. 1,477.

Looking for the most recent Wordle answer? Click here for today’s Wordle hints, as well as our daily answers and hints for The New York Times Mini Crossword, Connections, Connections: Sports Edition and Strands puzzles.

Today’s Wordle puzzle is a pretty tough one. I grew up on a farm, so I know the word, but I didn’t put it together right away, even though the letters are common ones. If you need a new starter word, check out our list of which letters show up the most in English words. If you need hints and the answer, read on.