Technologies

Scientists Develop ‘Cellular Glue’ That Could Heal Wounds, Regrow Nerves

One day, these special synthetic molecules could also help mitigate the organ shortage crisis.

Researchers from the University of California, San Francisco announced a fascinating innovation on Monday. They call it «cellular glue» and say it could one day open doors to massive medical achievements, like building organs in a lab for transplantation and reconstructing nerves that’ve been damaged beyond the reach of standard surgical repair.

Basically, the team engineered a set of synthetic molecules that can be manipulated to coax cells within the human body to bond with one another. Together, these molecules constitute the so-called «cellular glue» and act like adhesive molecules naturally found in and around cells that involuntarily dictate the way our tissues, nerves and organs are structured and anchored together.

Only in this case scientists can voluntarily control them.

«The properties of a tissue, like your skin for example, are determined in large part by how the different cells are organized within it,» Adam Stevens, a researcher at UCSF’s Cell Design Institute and first author of a paper in the journal Nature, said in a statement. «We’re devising ways to control this organization of cells, which is central to being able to synthesize tissues with the properties we want them to have.»

Doctors could eventually use the sticky material as a viable mechanism to mend patients’ wounds, regrow nerves otherwise deemed destroyed and potentially even work toward regenerating diseased lungs, livers and other vital organs.

That last bit could lend a hand in alleviating the crisis of donor organs rapidly running out of supply. According to the Health Resources and Services Administration, 17 people in the US die each day while on the waitlist for an organ transplant, yet every 10 minutes, another person is added to that list.

«Our work reveals a flexible molecular adhesion code that determines which cells will interact, and in what way,» Stevens said. «Now that we are starting to understand it, we can harness this code to direct how cells assemble into tissues and organs.»

Ikea cells

Right after babies are born (and even when they’re still in the womb) their cells essentially find it easy to reconnect with one another when a bond is lost. This is primarily because kids are still growing, so their cells are still actively coming together. But as a consequence, that’s also why their scratches and scrapes tend to heal quite quickly.

In other words, think of children’s cell molecules as having lots of clear-cut instructions on how to put themselves together to make tissues, organs and nerves. They’re like sentient little pieces of Ikea furniture with the store’s building booklet in hand.

As people get older, however, those biological Ikea instructions get put in the attic, the team explains. That’s because, for the most part, the body is pretty solidified — and this is sometimes a problem. For instance, when someone’s liver gets really damaged, their liver cell molecules may need to refer back to those Ikea instructions but can’t find them.

But that’s where «cellular glue» molecules come in. These rescuers can essentially be primed with those Ikea instructions before being sent into the body, so their blueprint is fresh. Scientists can load them up with information on which cell molecules to bond with and even how strongly to bond with them.

Then, these glue molecules can guide relevant cells toward one another, helping along the healing and regeneration processes.

«In a solid organ, like a lung or a liver, many of the cells will be bonded quite tightly,» explains a UCSF description of the new invention. «But in the immune system, weaker bonds enable the cells to flow through blood vessels or crawl between the tightly bound cells of skin or organ tissues to reach a pathogen or a wound.»

To make this kind of customization possible, the researchers added two important components to their cellular glue. First, part of the molecule acts as a receptor. It remains on the outside of the cell and determines which other cells the molecule is allowed to interact with. Second, there’s the bond-strength-tuner. This section exists within the cell. Mix and match those two traits and, the team says, you can create an array of cell adhesion molecules prepped to bond in various ways.

«We were able to engineer cells in a manner that allows us to control which cells they interact with, and also to control the nature of that interaction,» Wendell Lim, director of UCSF’s Cell Design Institute and senior author of the paper, said in a statement.

In fact, the team says the range of potential molecules is wide enough that they could inform the academic stage of medical studies, too. Researchers could make mock tissues, for example, to deepen understanding of the human body as a whole.

Or as Stevens put it, «These tools could be really transformative.»

Technologies

Today’s NYT Mini Crossword Answers for Thursday, Aug. 14

Here are the answers for The New York Times Mini Crossword for Aug. 14

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Today’s Mini Crossword isn’t too tough, and it has some fun movie and TV references. Just remember that «poster» can mean a couple of different things — it’s not always that photo of Def Leppard hanging on the wall. Want help with today’s NYT Mini Crossword? Read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

The Mini Crossword is just one of many games in the Times’ games collection. If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: Animals holding «Eat Mor Chikin» signs, in a classic ad campaign
Answer: COWS

5A clue: Suffix with Beatle or Wrestle
Answer: MANIA

6A clue: «Au revoir!»
Answer: ADIEU

7A clue: Ugly poster?
Answer: TROLL

8A clue: Be likely (to)
Answer: TEND

Mini down clues and answers

1D clue: Core group
Answer: CADRE

2D clue: Vegetable combined with celery and carrot to form «mirepoix»
Answer: ONION

3D clue: Handle, as a sword
Answer: WIELD

4D clue: «Better Call ___» («Breaking Bad» spinoff)
Answer: SAUL

5D clue: Damon of «Oppenheimer»
Answer: MATT

Technologies

The iPhone 17 Hasn’t Been Announced Yet, but There’s Already a Case for It

The new case makes a bold style statement, but there’s no official confirmation that it correctly reflects Apple’s upcoming phone.

One of the first cases for the iPhone 17 has made its appearance. Canadian tech accessory company Dbrand announced its Tank Case for the iPhone 17 is set to go on sale in September, the same month we’re expecting Apple to announce the eagerly awaited iPhone 17.

While we don’t know the price of the Tank Case yet, Dbrand has certainly made some striking design choices in the hard black shell case, including plenty of number codes, the Freemason Eye of Providence in what looks like a center designed for MagSafe connections and what appears to be Braille. Dbrand is light on details for now, but you can sign up with your email address to get notifications about the case.

A representative for Dbrand did not immediately respond to a request for comment.

Patrick Holland, CNET managing editor and mobile guru, cautions that these early-announced phone designs don’t always end up making it to the release date. Holland saw that happen just last year, when some manufacturers were forced to push quick redesigns to make room for the iPhone 16’s surprise camera control button.

«It’s become a yearly tradition,» Holland said. «We see companies try to be the first out with a new case design for the latest iPhone, even though the phone hasn’t been announced by Apple.»

«For Dbrand, it’s unclear whether the Tank case is designed based on rumors, or if the company got an early look at the iPhone 17 series, or were given a dummy model,» Holland said. «The case does feature a full body width camera bump that has been heavily leaked for the iPhone 17 Pro and 17 Pro Max. There’s one thing that’s for certain: Dbrand’s Tank case looks chunky and busy, especially for a sleek new iPhone.»

That’s why we’re also keeping a close eye on all the latest reports of iPhone 17 features, including rumors of a redesigned camera bump and a movable lens that could throw a curveball for third-party cases like this.

Social media buzz

Commenters on X shared a variety of opinions about the case. While one person wrote, «that case looks fire,» another wrote, «that case looks hideous.»

Commenters also wondered if the case design was revealing some previously unknown details about the iPhone 17.

«So the second button is basically confirmed?» one X commenter wrote. «Why would the case sport an area that looks pressable or ‘slideable’ otherwise?»

Another wrote, «Am I seeing that correctly? Three cameras on a base iPhone model finally.»

Others zeroed in on the idea that Apple likely does not want case manufacturers to reveal details about a phone before the company announces it, noting that Dbrand also unveiled a case for the Nintendo Switch 2 before that console came out.

«First the Switch 2, now the iPhone 17,» the one commenter wrote. «Yeahh, they’re never getting shit early to make cases anymore.»

Technologies

Apple Reportedly Planning AI Comeback, Complete With a Tabletop Robot

Home security cameras and a standalone smart display are also coming, the report says.

Apple wants a bigger place in your home, according to a report posted Wednesday from Bloomberg’s Mark Gurman. While you might think of Apple primarily because it provides your iPhone, Apple Watch, iPad, MacBook, AirPods and more, the tech giant reportedly hopes to use artificial intelligence to sell you a number of new smart home devices. Those devices may include a tabletop robot, home security cameras and a smart speaker with a screen.

A representative for Apple did not immediately respond to a request for comment.

Tabletop robot

According to Bloomberg, it’s the tabletop robot, reportedly coming in 2027, that is the center of the plan. Bloomberg — and CNET — have reported on this plan before. At that time, the company reportedly had two concepts in mind: a robot that can move around the home, and a tabletop robotic device.

Now, Bloomberg says the robot «will feature a lifelike version of Siri and the ability to engage with users throughout the day.» It reportedly resembles an iPad mounted on a movable limb that can reposition itself to face you.

Former CNET senior editor Lisa Eadicicco wrote in 2024 that «perhaps the biggest challenge when it comes to a home robot is that the market is unproven.» We’ve all seen the robot maid Rosie on the old Jetsons cartoon, but do we really need or want a robotic helper in our homes?

Standalone smart display

Another item Apple is reportedly working on is essentially a smart speaker with a screen. Bloomberg calls this a «stripped-down version of the robot.»

It won’t have a robotic arm or conversational Siri, but it should be able to do such things as music playback, note taking, control home devices and video conferencing. Bloomberg says it will run a new operating system called Charismatic.

Home security cameras

Home security cameras are becoming more and more popular, and Apple wants to move into that realm as well. The company will make cameras that will anchor an Apple security system, the report says.