Technologies

Scientists Develop ‘Cellular Glue’ That Could Heal Wounds, Regrow Nerves

One day, these special synthetic molecules could also help mitigate the organ shortage crisis.

Researchers from the University of California, San Francisco announced a fascinating innovation on Monday. They call it «cellular glue» and say it could one day open doors to massive medical achievements, like building organs in a lab for transplantation and reconstructing nerves that’ve been damaged beyond the reach of standard surgical repair.

Basically, the team engineered a set of synthetic molecules that can be manipulated to coax cells within the human body to bond with one another. Together, these molecules constitute the so-called «cellular glue» and act like adhesive molecules naturally found in and around cells that involuntarily dictate the way our tissues, nerves and organs are structured and anchored together.

Only in this case scientists can voluntarily control them.

«The properties of a tissue, like your skin for example, are determined in large part by how the different cells are organized within it,» Adam Stevens, a researcher at UCSF’s Cell Design Institute and first author of a paper in the journal Nature, said in a statement. «We’re devising ways to control this organization of cells, which is central to being able to synthesize tissues with the properties we want them to have.»

Doctors could eventually use the sticky material as a viable mechanism to mend patients’ wounds, regrow nerves otherwise deemed destroyed and potentially even work toward regenerating diseased lungs, livers and other vital organs.

That last bit could lend a hand in alleviating the crisis of donor organs rapidly running out of supply. According to the Health Resources and Services Administration, 17 people in the US die each day while on the waitlist for an organ transplant, yet every 10 minutes, another person is added to that list.

«Our work reveals a flexible molecular adhesion code that determines which cells will interact, and in what way,» Stevens said. «Now that we are starting to understand it, we can harness this code to direct how cells assemble into tissues and organs.»

Ikea cells

Right after babies are born (and even when they’re still in the womb) their cells essentially find it easy to reconnect with one another when a bond is lost. This is primarily because kids are still growing, so their cells are still actively coming together. But as a consequence, that’s also why their scratches and scrapes tend to heal quite quickly.

In other words, think of children’s cell molecules as having lots of clear-cut instructions on how to put themselves together to make tissues, organs and nerves. They’re like sentient little pieces of Ikea furniture with the store’s building booklet in hand.

As people get older, however, those biological Ikea instructions get put in the attic, the team explains. That’s because, for the most part, the body is pretty solidified — and this is sometimes a problem. For instance, when someone’s liver gets really damaged, their liver cell molecules may need to refer back to those Ikea instructions but can’t find them.

But that’s where «cellular glue» molecules come in. These rescuers can essentially be primed with those Ikea instructions before being sent into the body, so their blueprint is fresh. Scientists can load them up with information on which cell molecules to bond with and even how strongly to bond with them.

Then, these glue molecules can guide relevant cells toward one another, helping along the healing and regeneration processes.

«In a solid organ, like a lung or a liver, many of the cells will be bonded quite tightly,» explains a UCSF description of the new invention. «But in the immune system, weaker bonds enable the cells to flow through blood vessels or crawl between the tightly bound cells of skin or organ tissues to reach a pathogen or a wound.»

To make this kind of customization possible, the researchers added two important components to their cellular glue. First, part of the molecule acts as a receptor. It remains on the outside of the cell and determines which other cells the molecule is allowed to interact with. Second, there’s the bond-strength-tuner. This section exists within the cell. Mix and match those two traits and, the team says, you can create an array of cell adhesion molecules prepped to bond in various ways.

«We were able to engineer cells in a manner that allows us to control which cells they interact with, and also to control the nature of that interaction,» Wendell Lim, director of UCSF’s Cell Design Institute and senior author of the paper, said in a statement.

In fact, the team says the range of potential molecules is wide enough that they could inform the academic stage of medical studies, too. Researchers could make mock tissues, for example, to deepen understanding of the human body as a whole.

Or as Stevens put it, «These tools could be really transformative.»

Technologies

Researchers Discover 18 Popular VPNs Are Connected: Why This Matters

All are owned by 3 separate groups but CNET’s recommended VPNs are not on the list

Virtual private networks are popular ways to keep your online activity private and hide your physical location from your internet service provider and apps. But it’s obviously important to choose a safe and secure VPN.

Three university researchers have discovered that 18 of the most widely used VPNs have shared infrastructures with serious security flaws that could expose customers’ browsing activity and leave their systems vulnerable to corrupted data. These VPNs are among the top 100 most popular on the Google Play Store, comprising more than 700 million downloads.

Read more: Best VPN Service for 2025: Our Top Picks in a Tight Race

The peer-reviewed study by the Privacy Enhancing Technologies Symposium found that these VPNs, despite calling themselves independent businesses, are actually grouped into three separate families of companies.

None of CNET’s recommended VPNs — ExpressVPN, NordVPN, Surfshark, Proton VPN and Mullvad — are on the list. (If you currently don’t have a VPN, here’s why you might want to start using one.)

According to the findings, these are the three groups that contain the 18 VPNs:

Family A: Turbo VPN, Turbo VPN Lite, VPN Monster, VPN Proxy Master, VPN Proxy Master Lite, Robot VPN, Snap VPN and SuperNet VPN
Family B: Global VPN, Inf VPN, Melon VPN, Super Z VPN, Touch VPN, VPN ProMaster, XY VPN and 3X VPN
Family C: X-VPN and Fast Potato VPN

Researchers determined that the VPNs in Family A are shared between three providers linked to Qihoo 360, a firm identified by the US Department of Defense as a Chinese military company. The VPNs in Family B use the same IP addresses from the same hosting company.

Know your VPN’s parent company

It’s a cautionary tale about why it’s important to know who’s behind the VPN you’re using, says CNET senior writer Attila Tomaschek.

«It’s also crucial to know what kinds of data the VPN provider is sharing with its parent company and affiliated entities,» Tomaschek said. «Some of these companies may even be compelled to log customer activity and share it with authorities, depending on the jurisdiction in which they operate.»

Despite the warnings, Tomaschek says it’s not so easy to figure out who controls your VPN. But he says there are measures that customers can take.

«Users can do a few things to help ensure the VPN they’re using is reputable,» Tomaschek says. «Check the privacy policy — specifically for terms like ‘logging,’ ‘data sharing’ or ‘data collection.’ A Google search of the provider can help determine whether the VPN has been involved in questionable activity. Read detailed, unbiased reviews from reputable sources. Be especially wary of signing on with a free VPN, even if it’s listed as a top choice in your app store.»

The PETS researchers examined the most downloaded VPNs on Android, looking for overlaps among business paperwork, web presence and codebase. After identifying code similarities, they were able to group the 18 VPNs into three groups. The study was initially spurred by VPN Pro’s own findings, «Who owns your VPN? 105 VPNs run by just 24 companies.»

CNET’s Tomaschek has advice for anyone who has been using one of these 18 VPNs.

«I’d recommend deleting it from your device immediately,» he said. «If you suspect that any sensitive personal data may have been compromised, it’s a good idea to keep an eye on your credit report and look into services like dark web monitoring or identity theft protection.»

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Sept. 6, #348

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Sept. 6, No. 348.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition was a stumper. But if you play cards, the green group is a fun one for sure. If you’re struggling but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by the Times. It doesn’t show up in the NYT Games app but appears in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Racket time.

Green group hint: Ante up!

Blue group hint: NY signal-callers.

Purple group hint: Coach’s CV.

Answers for today’s Connections: Sports Edition groups

Yellow group: Tennis statistics.

Green group: Poker variants, familiarly.

Blue group: Giants QBs, past and present.

Purple group: Teams coached by Lane Kiffin.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is tennis statistics. The four answers are aces, double faults, unforced errors and winners.

The green words in today’s Connections

The theme is poker variants, familiarly. The four answers are hold ’em, horse, Omaha and stud.

The blue words in today’s Connections

The theme is Giants QBs, past and present. The four answers are Manning, Simms, Tittle and Wilson.

The purple words in today’s Connections

The theme is teams coached by Lane Kiffin. The four answers are Mississippi, Raiders, Tennessee and USC.

Technologies

Hollow Knight Silksong Guide: Read These 11 Tips Before Starting

Need help finding rosaries and maps? Here are 11 tips to help you begin your journey.

The indie gaming classic Hollow Knight’s long-awaited sequel, Silksong, is here. Just like the 2019 original, the new game is mysterious and labyrinthine. I’m having an absolute blast playing it, but there are a lot of quirks and challenges you’re going to have to face.

Here are 11 tips to help you navigate the first couple hours of the exciting — and difficult — Silksong.

Read more: I Played Silksong on the ROG Xbox Ally X and I’m Ready for More

11 Hollow Knight: Silksong tips for beginners

Early rosary cache

Rosaries are this game’s version of currency, which you can use to buy amulets and maps from early game merchants. If you die, you’ll have to recover them from your corpse in order to collect what was lost. In the opening area of the game, you can find a rosary cache to give your wallet a boost early on. Right before entering Bone Bottom, there’s a hole to drop down. Hold left as you fall and you’ll find a bone wall you can break. Here you’ll find your reward.

Learn the pogo

Bouncing off enemies is an early way to double jump. To do it, hold down while attacking in the air. It’s much harder to pull off than it was in Hollow Knight due to Hornet’s attacks, which are angled diagonally rather than straight down. However, if Silksong is anything like the first, you’ll be expected to master this technique in order to find and unlock everything in the game — there could be secret areas that can only be reached or bosses that can only be defeated with this technique. Make sure to master this skill early on.

First spool fragment and shortcut

After meeting Shakra, the map merchant, head left into the next screen. There is a flying enemy near the far left wall. Use the pogo jump technique off of them to reach and exit the room in the top left corner. If you kill the enemy, simply leave the area and rest at the nearby bench to respawn them (benches also save your game). After reaching the next room, drop down the first hole. There’s also a rosary cache to your right as you descend. Continue down until you reach a lever, which activates the elevator, giving you a shortcut back to Bone Bottom.

From the top of the elevator shaft, head right. You’ll also see an enemy glowing green below you as you progress. It holds a Moss Berry, and in order to get it, you’ll either have to keep pogo attacking them or fall and slash repeatedly. You can use your new elevator to keep ascending back up if you fall down.

Eventually, you’ll find another cache of rosaries hanging in a small room, but be careful, as they’re boobytrapped with spikes right underneath. However, these spikes only activate once, so you can just wait for them to disappear. Attack the wall in the bottom left of this room to open a secret door that leads to the Spool Fragment — you’ll want to prioritize collecting these, as they increase your max silk capacity.

Buy the first four items from Shakra

Maps are extremely useful in Silksong, so buy them whenever you have the chance. When you first meet Shakra, they’ll have two for you. In addition, you can also buy the Quill and Compass. These will help fill in the map and, if equipped, show your location. Try and grind out enough cash to buy all four of these items. If you’re low on funds, the enemies in the area to your left will drop around five rosaries each, and there’s a nearby bench you can sit on to keep respawning them.

If you followed my advice and collected the Spool Fragment above, you should have more than enough currency to buy all four.

View the entire map

Holding down LB (on Xbox) will bring up the map of your current area. In order to see the entire area, and how each section connects to one another, double tap LB instead.

Choral Commandment

You can find a Choral Commandment, which can be given to a certain collector later on, shortly after encountering Shakra. Climb upwards from their position and to the left. Up again past the lever and there is a breakable wall immediately left of you.

Moss Druid

Right after obtaining the Silk Spear technique, head to the bottom right corner of the room and destroy the webs with your new skill. Inside and past the right exit is Moss Druid (and a save bench) who will give you your first side quest of finding three moss berries. If you found one early on, and a second one that I mentioned while going for the Spool Fragment, you can collect a third just below them by dropping down the hole left of the bench and past a hidden wall in the bottom right corner of the room. Finishing this side quest will earn you an achievement.

Easier healing

Unlike in Hollow Knight, you don’t need to hold down the bind button (B on an Xbox controller) to heal. In Silksong, you simply need to tap it once you have enough silk. This will grant you three pips of life back. You can also heal while in the air, so take advantage of it when landing could mean your death.

Different types of equipment

Hollow Knight only had one type of equipment, but Silksong has four. They’re distinguished by colors: white, red, blue and yellow. White is for your spells, such as the Silk Spear, red is for tools, blue holds amulets, and yellow is for additional items, such as the compass. You can only equip one of each at a time (at least for now).

How to defeat the Bell Beast

The first real boss fight of the game is the Bell Beast and it’s located shortly after collecting the Silk Spear skill.

The Beast has three main attacks. The first will see either side of the ground rumble followed by the Beast surfacing and charging toward you. Simply jump over it and do a pogo attack as it passes. The second attack begins like the first, with the ground on the side of the arena rumbling, but this time the Beast will launch into the air and arc over you. It’s very easy to just walk the opposite direction to avoid getting crushed. You can also quickly counter and get in two attacks while it tries to get unstuck from the wall. The last attack will start a little differently — this time the center ground will rumble. The Beast will pop up and launch two bell projectiles horizontally. To dodge, just hop over the bell.

When you’ve whittled the boss’s health down halfway, the Beast will surface and scream, shaking the whole area. This will cause bells to start dropping down from the ceiling while you continue the fight. They’re pretty easy to avoid since they only bounce once before disappearing. Simply hop over them as you continue the pattern of attacking and dodging the Beast’s three attacks.

Unlocks after the Bell Beast

After defeating the Bell Beast you get an achievement and a silk heart. This will regenerate a little bit of silk automatically after every use. After falling in combat, the Bell Beast will also have a change of heart and become your mode of fast travel.

Make sure to revisit Bone Bottom once you’re victorious as you’ll now be able to take on additional side quests from a sign in town.

Hopefully these tips give you a better grasp of the dangerous and complex world as you begin your adventure in Silksong.