Technologies
Scientists Develop ‘Cellular Glue’ That Could Heal Wounds, Regrow Nerves
One day, these special synthetic molecules could also help mitigate the organ shortage crisis.
Researchers from the University of California, San Francisco announced a fascinating innovation on Monday. They call it «cellular glue» and say it could one day open doors to massive medical achievements, like building organs in a lab for transplantation and reconstructing nerves that’ve been damaged beyond the reach of standard surgical repair.
Basically, the team engineered a set of synthetic molecules that can be manipulated to coax cells within the human body to bond with one another. Together, these molecules constitute the so-called «cellular glue» and act like adhesive molecules naturally found in and around cells that involuntarily dictate the way our tissues, nerves and organs are structured and anchored together.
Only in this case scientists can voluntarily control them.
«The properties of a tissue, like your skin for example, are determined in large part by how the different cells are organized within it,» Adam Stevens, a researcher at UCSF’s Cell Design Institute and first author of a paper in the journal Nature, said in a statement. «We’re devising ways to control this organization of cells, which is central to being able to synthesize tissues with the properties we want them to have.»
Doctors could eventually use the sticky material as a viable mechanism to mend patients’ wounds, regrow nerves otherwise deemed destroyed and potentially even work toward regenerating diseased lungs, livers and other vital organs.
That last bit could lend a hand in alleviating the crisis of donor organs rapidly running out of supply. According to the Health Resources and Services Administration, 17 people in the US die each day while on the waitlist for an organ transplant, yet every 10 minutes, another person is added to that list.
«Our work reveals a flexible molecular adhesion code that determines which cells will interact, and in what way,» Stevens said. «Now that we are starting to understand it, we can harness this code to direct how cells assemble into tissues and organs.»
Ikea cells
Right after babies are born (and even when they’re still in the womb) their cells essentially find it easy to reconnect with one another when a bond is lost. This is primarily because kids are still growing, so their cells are still actively coming together. But as a consequence, that’s also why their scratches and scrapes tend to heal quite quickly.
In other words, think of children’s cell molecules as having lots of clear-cut instructions on how to put themselves together to make tissues, organs and nerves. They’re like sentient little pieces of Ikea furniture with the store’s building booklet in hand.
As people get older, however, those biological Ikea instructions get put in the attic, the team explains. That’s because, for the most part, the body is pretty solidified — and this is sometimes a problem. For instance, when someone’s liver gets really damaged, their liver cell molecules may need to refer back to those Ikea instructions but can’t find them.
But that’s where «cellular glue» molecules come in. These rescuers can essentially be primed with those Ikea instructions before being sent into the body, so their blueprint is fresh. Scientists can load them up with information on which cell molecules to bond with and even how strongly to bond with them.
Then, these glue molecules can guide relevant cells toward one another, helping along the healing and regeneration processes.
«In a solid organ, like a lung or a liver, many of the cells will be bonded quite tightly,» explains a UCSF description of the new invention. «But in the immune system, weaker bonds enable the cells to flow through blood vessels or crawl between the tightly bound cells of skin or organ tissues to reach a pathogen or a wound.»
To make this kind of customization possible, the researchers added two important components to their cellular glue. First, part of the molecule acts as a receptor. It remains on the outside of the cell and determines which other cells the molecule is allowed to interact with. Second, there’s the bond-strength-tuner. This section exists within the cell. Mix and match those two traits and, the team says, you can create an array of cell adhesion molecules prepped to bond in various ways.
«We were able to engineer cells in a manner that allows us to control which cells they interact with, and also to control the nature of that interaction,» Wendell Lim, director of UCSF’s Cell Design Institute and senior author of the paper, said in a statement.
In fact, the team says the range of potential molecules is wide enough that they could inform the academic stage of medical studies, too. Researchers could make mock tissues, for example, to deepen understanding of the human body as a whole.
Or as Stevens put it, «These tools could be really transformative.»
Technologies
Metroid Prime 4 Beyond on Switch: This Was Worth Waiting For
Come on in, the space desert’s fine.
Winter’s coming, and Nintendo has delivered an epic Switch game to get lost in for the season. After a week of playing Metroid Prime 4: Beyond, I know this is the one I’ve been waiting for. It’s full of alien motorbikes, alien relics, psychic powers and a lot of puzzle-solving.
It’s been a long time since I played a Metroid Prime game. I used to huddle around my GameCube in California, playing the first one. I never got sucked too far into 2D Metroid games, but Prime’s mysterious unfolding caverns and worlds felt like exploring space tombs. It’s always had a bit of a 3D Zelda vibe to me. The Prime games felt more powerful, more immersive than the 2D ones, even Dread. (The original Prime is on Switch too, remastered and worth playing.)
With Prime 4, announced more than eight years ago, it took me some time to get back into it. But now it’s all I think about playing. My recommendation is to just go in for the experience. Go in knowing nothing, and maybe even skip everything in this review, or any other review. Mystery is Metroid’s calling card. Your big adventure on the Switch is here.
If you’re new, here’s the deal: 3D Metroid is a first-person shooter adventure, but with a lot more emphasis on exploration and puzzle-solving than straight-up battle. Once again, you play as Samus, the bounty hunter who quietly explores her world. Enemies and bosses do pop up, and they can be hard, but expect challenges similar to boss battles in a Zelda game. Just like all the other Metroid games, your various powers are lost and must be found again, piece by piece. Besides running and jumping and shooting, you can morph into a ball. Or, this time, hop on a Tron-like space bike called Vi-O-La.
I wasn’t sure if Prime 4 would be for me, or if I’d feel lost in lore I’d forgotten or hadn’t absorbed (since I hadn’t finished Prime 2 or 3, and barely remember what happened in Prime). It’s OK. This game assumes you might be coming in clean, though knowing the Metroid series will help.
Hollywood flair, but not too much
It’s also clear that Nintendo is pushing the Metroid series more into the mainstream. With Nintendo making theme parks and films now, Metroid seems like a future candidate for another franchise spin-off. The game’s stellar opening video sequences feel like being propelled into Star Wars, and yes, the new talking side characters are peppered throughout. Some are annoying, some a bit clichéd, but all seem like they’re possibly auditioning for roles in future entertainment to come.
That annoying guy who seemed to always barge in during early game demos a few weeks ago? He doesn’t bother me too much. Definitely a lot of chat at first, but it settles down later. And, good news: So far, hours into playing, these characters don’t bother you all the time. In fact, in most of the maze-like maps, they’re out of communication range, and you’re on your own. Don’t worry, the lonely Samus vibe is still there.
Just enough feelings of getting truly lost
Samus ends up isolated on a new planet, Viewros, which is full of ancient artifacts from a civilization called the Lamorn that need to be awakened. You don’t know why you’re there, and you don’t know where to go. I mean, there are maps, and suggestions, and sometimes the game pings you a specific map goal. But the game doesn’t hold your hand much. I often wondered what to do next, which isn’t a bad thing at all. There are in-game suggestions and clues, and the design also lends itself to further suggestions.
A semi-open world
And what I’m still wrapping my head around is the vast desert overworld of Viewros, which exists within a mega map where specific regions to visit are scattered throughout. The desert feels largely empty, but there are mysterious things to find in it, some of which can’t even be accessed at first. Underground shrine-like caves. Pieces of rubble. Odd machines.
Also, the motorbike you uncover and ride — Vi-O-La, aka the Zelda Horse of Metroid Prime 4 — adds a nice bit of open-world feel here. Not a massive one so far, but enough to give the game dimension. It’s not Breath of the Wild, but it is a bit like Ocarina of Time’s handling of space. I love riding that Tron bike around, and I want all the Metroid games to add this type of layer. (Would there ever be a spaceship to fly? Is there one later, in this game? I don’t even know yet.)
It’s great (on Switch 2)
I haven’t played Metroid Prime 4 on the original Switch, but just like Pokemon Legends Z-A, it’s both Switch and Switch 2 playable. The Switch 2 version features a silky-smooth 60 frames per second (or 120fps at a lower resolution) and a fun mouse mode with the Joy-Cons, but I barely used it. I just find standard controls perfectly great as they are.
And, you do a lot of scanning of things in this game, using a Psychic Visor mode that sometimes activates relics, or scans and catalogs creatures, items and artifacts. That left trigger is maybe the most-used button in the game.
The game plays great both docked and handheld, which is good news because I’ll be traveling with this one for a while. I’m nowhere near finishing (sorry, I’m a slow gamer), but this earns the hype, even if it’s not a total reinvention of the control and play style. Now erase your brain of everything I said and dive in. Better you know nothing at all.
Technologies
Cyber Monday Might Be Gone, but This Record-Low Price on the Google Pixel 9 Is Still Here
Take hundreds off the Google Pixel 9. But hurry, there’s not much time left to score this after-Cyber Monday deal.
If you’re looking to get your hands on one of the best Android phones out there, Google is the best place to look. The company has been producing stellar phones for some time now. But like all great things, it certainly comes with a pretty big price tag. If you’re not eager to get the latest and greatest model, Cyber Monday had some pretty nice deals you can still grab while they hang around a smidge longer. You can save significantly on previous-generation devices if that works for you.
Right now, you can pick up the previous-gen Google Pixel 9 for just $499. This post-Cyber Monday deal brings the phone to its lowest-ever price with a 38% discount. That’s an exceptional price for one of the best phones you can buy, but that also means it’s unlikely to last for very long. So, if you want to pick this one up, we recommend doing so soon before it sells out.
The Google Pixel 9 is the sweet spot if you’re looking for a compact phone that doesn’t compromise on camera, performance or display specs. It has a 6.3-inch display, a long-lasting battery and is 5G-ready. This previous-gen flagship’s camera system is the same as the bigger model of its series. It also comes equipped with 12GB of RAM and 256GB of storage.
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The phone is available in multiple colors, but the special price isn’t offered for all of them. For that reason, we suggest checking the price of your preferred color before placing your order. Don’t worry if the Pixel 9 isn’t for you, though.
Not the phone you wanted? We’re rounding up all the remaining Cyber Monday phone deals so you don’t wind up paying more than you need to.
MOBILE DEALS OF THE WEEK
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$749 (save $250)
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$475 (save $175)
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$499 (save $300)
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$900 (save $400)
Why this deal matters
This Pixel 9 isn’t the latest that Google has to offer, but it’s still a great option. The Pixel 9 will continue to receive Android feature and security updates for a long time to come. That means you won’t need to replace your Pixel for years, making this deal an even better value. If you’re an Android fan who likes your phones to be as straightforward as possible, Google’s Pixel phones are a great place to start your search. And now that Cyber Monday is behind us, this deal won’t last much longer.
Technologies
I Can’t Believe the Apple Watch SE 3 Is Still on Sale for a Record-Low $199
It’s unlikely that this $50 post-Cyber Monday discount will last for much longer, so you’ll want to get your order in soon.
It’s not easy to find discounts on the latest and greatest Apple tech. So I was pretty surprised when the Apple Watch SE 3 (which just hit shelves this September) went on sale ahead of Black Friday. And I’m even more surprised that it’s still on sale now that Cyber Monday has come and gone.
Amazon still has this budget-friendly smartwatch on sale for an even more affordable $199. That’s a $50 discount and the all-time lowest price we’ve seen since its release. We’re expecting this deal to disappear soon now that most sales are winding down, so be sure to get your order in fast, or you could miss out.
Even at full price, CNET smartwatch expert Vanessa Hand Orellana called the third-gen SE a «$250 steal that delivers nearly everything you’d want from a wearable, with surprisingly few compromises.»
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It’s equipped with the same S10 processor as the Series 11 and Ultra 3, and offers many of the same features, like fast charging, 5G connectivity and new wellness tools.
Plus, the vibrant 40mm display is always on, so you can check the time with a glance. Other helpful features include onboard Siri, fall detection and a durable design that’s water-resistant up to 50 meters.
SMARTWATCH DEALS OF THE WEEK
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$339 (save $60)
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$250 (save $100)
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$300 (save $50)
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$150 (save $100)
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$49 (save $30)
Why this deal matters
Deals on the latest Apple tech are few and far between, which makes this Apple Watch SE 3 discount a welcome surprise. You can pick it up for a record-low $199 right now at Amazon, which is just half the price of the flagship Series 11. If you prefer a larger display, the 44mm model is also $50 off, dropping the price to $229.
You can also find plenty of other bargains on the latest and previous-gen models in our full roundup of all the best Apple Watch deals.
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