Technologies

Scientists Develop ‘Cellular Glue’ That Could Heal Wounds, Regrow Nerves

One day, these special synthetic molecules could also help mitigate the organ shortage crisis.

Researchers from the University of California, San Francisco announced a fascinating innovation on Monday. They call it «cellular glue» and say it could one day open doors to massive medical achievements, like building organs in a lab for transplantation and reconstructing nerves that’ve been damaged beyond the reach of standard surgical repair.

Basically, the team engineered a set of synthetic molecules that can be manipulated to coax cells within the human body to bond with one another. Together, these molecules constitute the so-called «cellular glue» and act like adhesive molecules naturally found in and around cells that involuntarily dictate the way our tissues, nerves and organs are structured and anchored together.

Only in this case scientists can voluntarily control them.

«The properties of a tissue, like your skin for example, are determined in large part by how the different cells are organized within it,» Adam Stevens, a researcher at UCSF’s Cell Design Institute and first author of a paper in the journal Nature, said in a statement. «We’re devising ways to control this organization of cells, which is central to being able to synthesize tissues with the properties we want them to have.»

Doctors could eventually use the sticky material as a viable mechanism to mend patients’ wounds, regrow nerves otherwise deemed destroyed and potentially even work toward regenerating diseased lungs, livers and other vital organs.

That last bit could lend a hand in alleviating the crisis of donor organs rapidly running out of supply. According to the Health Resources and Services Administration, 17 people in the US die each day while on the waitlist for an organ transplant, yet every 10 minutes, another person is added to that list.

«Our work reveals a flexible molecular adhesion code that determines which cells will interact, and in what way,» Stevens said. «Now that we are starting to understand it, we can harness this code to direct how cells assemble into tissues and organs.»

Ikea cells

Right after babies are born (and even when they’re still in the womb) their cells essentially find it easy to reconnect with one another when a bond is lost. This is primarily because kids are still growing, so their cells are still actively coming together. But as a consequence, that’s also why their scratches and scrapes tend to heal quite quickly.

In other words, think of children’s cell molecules as having lots of clear-cut instructions on how to put themselves together to make tissues, organs and nerves. They’re like sentient little pieces of Ikea furniture with the store’s building booklet in hand.

As people get older, however, those biological Ikea instructions get put in the attic, the team explains. That’s because, for the most part, the body is pretty solidified — and this is sometimes a problem. For instance, when someone’s liver gets really damaged, their liver cell molecules may need to refer back to those Ikea instructions but can’t find them.

But that’s where «cellular glue» molecules come in. These rescuers can essentially be primed with those Ikea instructions before being sent into the body, so their blueprint is fresh. Scientists can load them up with information on which cell molecules to bond with and even how strongly to bond with them.

Then, these glue molecules can guide relevant cells toward one another, helping along the healing and regeneration processes.

«In a solid organ, like a lung or a liver, many of the cells will be bonded quite tightly,» explains a UCSF description of the new invention. «But in the immune system, weaker bonds enable the cells to flow through blood vessels or crawl between the tightly bound cells of skin or organ tissues to reach a pathogen or a wound.»

To make this kind of customization possible, the researchers added two important components to their cellular glue. First, part of the molecule acts as a receptor. It remains on the outside of the cell and determines which other cells the molecule is allowed to interact with. Second, there’s the bond-strength-tuner. This section exists within the cell. Mix and match those two traits and, the team says, you can create an array of cell adhesion molecules prepped to bond in various ways.

«We were able to engineer cells in a manner that allows us to control which cells they interact with, and also to control the nature of that interaction,» Wendell Lim, director of UCSF’s Cell Design Institute and senior author of the paper, said in a statement.

In fact, the team says the range of potential molecules is wide enough that they could inform the academic stage of medical studies, too. Researchers could make mock tissues, for example, to deepen understanding of the human body as a whole.

Or as Stevens put it, «These tools could be really transformative.»

Technologies

Chrome Autofill Now Supports Passport, Driver’s License and Vehicle Info

Soon, you’ll never need to remember anything ever again.

Computer users are accustomed to web browsers autofilling everything from names and addresses to credit card numbers. Now, Google Chrome is adding new enhanced autofill options that allow users to automatically populate fields for passports, driver’s licenses, and their vehicle’s license plate or VIN, Google said in a blog post on Monday.

Desktop users must choose to turn on the feature, which is called enhanced autofill. Otherwise, it stays off. To turn it on, open Chrome, and at the top right of your browser, select more, then settings, then autofill and passwords. Finally, choose enhanced autofill and turn it in.

Google says Chrome now can «better understand complex forms and varied formatting requirements, improving accuracy across the web.» The company also says that enhanced autofill will be «private and secure.»

This enhanced autofill update is available in all languages, and more data options will be supported in the coming months.

A representative for Google said the company had no additional comment.

Don’t miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source.

Chrome is a critical component in Google’s business. The web browser, currently the most popular in the world with a 73% market share, according to GlobalStats, provides the company with valuable user data that it uses to sell advertising. Advertising is how Google makes the majority of its revenues. New features help keep users loyal to Chrome, making it more difficult for them to switch to other browsers, including those from companies like Perplexity and OpenAI.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Nov. 4, #407

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Nov. 4, No. 407.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition is a tough one. The Connections: Sports Edition puzzle makers will never run out of categories because they have discovered they can just pick one athlete and make a connections group out of four facts about that person. They do that today with the blue category, so if you don’t know that one player, you’re out of luck. If you’re struggling but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by the Times. It doesn’t show up in the NYT Games app but appears in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Get up and go!

Green group hint: College hoops.

Blue group hint: Famous basketball player.

Purple group hint: Not fair, but…

Answers for today’s Connections: Sports Edition groups

Yellow group: Energy.

Green group: Men’s college basketball teams with the most championships.

Blue group: Associated with Damian Lillard.

Purple group: Foul ____.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is energy. The four answers are pep, verve, vigor and zip.

The green words in today’s Connections

The theme is men’s college basketball teams with the most championships. The four answers are Kentucky, UCLA, UCONN and UNC.

The blue words in today’s Connections

The theme is associated with Damian Lillard. The four answers are 0, Dame Time, Trail Blazers and Weber State.

The purple words in today’s Connections

The theme is foul ____. The four answers are out, shot, territory and tip.

Technologies

Today’s NYT Mini Crossword Answers for Tuesday, Nov. 4

Here are the answers for The New York Times Mini Crossword for Nov. 4.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Need some help with today’s Mini Crossword? There are a few tricky clues, so read on for the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.