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Doctors Transplant Genetically Modified Pig’s Heart Into Human in Medical First

The milestone operation shines a hopeful light for the long ledger of patients awaiting organ transplants.

Last month, an ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time, marking a historic moment for medicine. About five weeks post-surgery, the 57-year-old organ recipient, David Bennett, was still doing well.

«His heart function looks great, his blood pressure looks very good, and in fact, he’s on medicine to reduce his blood pressure. That’s how good it is right now,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the heart, said in an update on Feb 11.

On Feb. 14, medical staff caring for Bennett even released an inspiring clip of him watching this year’s Super Bowl and singing «America the Beautiful» as Jhené Aiko performed her rendition at the game. While the team continues to monitor Bennett closely, particularly due to reported preoperative kidney setbacks that persisted after the procedure, Griffith offered encouraging words: «Beyond that, I’d say all thumbs are up.»

This medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis. «There are simply not enough donor human hearts available to meet the long list of potential recipients,» Griffith, who’s also a professor in transplant surgery at the university, said in a statement.

«We are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,» Griffith said. According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant, and more than 17 patients die each day while still on the waitlist.

Leading up to his surgery, Bennett was one of those anxious patients on hold. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, nonhuman-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

«We’ve been asked how we would define success,» Griffith said in the team’s most recent update, underlining his cautious hope. «I think we’ve surpassed, in many measures, what we expected.»

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Technologies

Today’s NYT Connections Hints, Answers and Help for Nov. 22, #895

Here are some hints and the answers for the NYT Connections puzzle for Nov. 22, #895.

Looking for the most recent Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles.

Today’s NYT Connections puzzle has a fun mix of categories. If you know your unusual foods, you should get the blue group easily enough. If you need help sorting the answers into groups, you’re in the right place. Read on for clues and today’s Connections answers.

The Times now has a Connections Bot, like the one for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. Players who are registered with the Times Games section can now nerd out by following their progress, including the number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak.

Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time

Hints for today’s Connections groups

Here are four hints for the groupings in today’s Connections puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Not a lot.

Green group hint: Like Popeye.

Blue group hint: Yum!

Purple group hint: Let’s Make a ____.

Answers for today’s Connections groups

Yellow group: Little bit.

Green group: Sailor.

Blue group: Tropical fruits/vegetables.

Purple group: ____ deal.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections answers?

The yellow words in today’s Connections

The theme is little bit. The four answers are dab, drop, splash and touch.

The green words in today’s Connections

The theme is sailor. The four answers are salty dog, skipper, swab and tar.

The blue words in today’s Connections

The theme is tropical fruits/vegetables. The four answers are bitter melon, chayote, durian and soursop.

The purple words in today’s Connections

The theme is ____ deal. The four answers are big, plea, raw and sweetheart.

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Technologies

Today’s NYT Strands Hints, Answers and Help for Nov. 22 #629

Here are hints and answers for the NYT Strands puzzle for Nov. 22, No. 629.

Looking for the most recent Strands answer? Click here for our daily Strands hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections and Connections: Sports Edition puzzles.

Today’s NYT Strands puzzle is a fun one, if you know your college sports. But some of the answers are difficult to unscramble; if you need hints and answers, read on.

I go into depth about the rules for Strands in this story. 

If you’re looking for today’s Wordle, Connections and Mini Crossword answers, you can visit CNET’s NYT puzzle hints page.

Read more: NYT Connections Turns 1: These Are the 5 Toughest Puzzles So Far

Hint for today’s Strands puzzle

Today’s Strands theme is: Ivy League

If that doesn’t help you, here’s a clue: Academics meets athletics.

Clue words to unlock in-game hints

Your goal is to find hidden words that fit the puzzle’s theme. If you’re stuck, find any words you can. Every time you find three words of four letters or more, Strands will reveal one of the theme words. These are the words I used to get those hints but any words of four or more letters that you find will work:

  • SEAT, SEATS, SITE, BLUR, BEAT, BEATS, RATS, STAR, STARE, STARES, POUR, POURS

Answers for today’s Strands puzzle

These are the answers that tie into the theme. The goal of the puzzle is to find them all, including the spangram, a theme word that reaches from one side of the puzzle to the other. When you have all of them (I originally thought there were always eight but learned that the number can vary), every letter on the board will be used. Here are the nonspangram answers:

  • BEARS, LIONS, TIGERS, QUAKERS, CRIMSON, BULLDOGS

Today’s Strands spangram

Today’s Strands spangram is SPORTSTEAM. To find it, start with the S that’s three letters to the right on the top row, and wind down.

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Technologies

Save $350 on the iPhone of Androids This Black Friday

The Google Pixel 9 Pro is among the best Android has to offer, and it’s easy to see why. Put one in your pocket for less this holiday season.

Black Friday deals alert: The Google Pixel 9 Pro is currently $350 off during early Black Friday sales, making it an impressive $649.

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Deals are selected by the CNET Group commerce team, and may be unrelated to this article.

CNET’s key takeaways

While Android users swear by them, a lot of other people consider Android phones to feel overly complex. The user interface isn’t quite as easy to adjust as Apple’s offering. While it may sound unreasonable, Samsung’s Galaxy S25 range, for example, has deep menu settings that let you tweak nearly every aspect of the phone. It can feel overwhelming — and even a bit off-putting.

For many Android users, the deep customizability of the OS has always been a selling point over the more simplistic iOS found on Apple’s iPhones. But just because you want an Android phone, doesn’t necessarily mean you’re a fanatical tech nerd who wants to tinker with menus all day. 

While it’s not the latest model — the Pixel 10 Pro is $899 right now — the Pixel 9 Pro is the easiest Android phone I’ve ever used, and there are a number of reasons why. 

My experience with the Pixel 9 Pro

First, it’s Google’s own phone, meaning there’s no secondary manufacturer software skin over the top of the operating system. It’s pure, uncut Android. Google’s interface is clean, easy to read and uncluttered. Naturally, it uses Google’s own apps by default. Samsung, meanwhile, loads its phones up with its own browser, email client and photo gallery, all of which sit beside Google’s Chrome, Gmail and Photos apps, meaning you already have duplicates of each tool. 

Samsung is not the only phonemaker to do this. Almost all Android phone companies load their phones up with at least their own browser and gallery app, while some companies, like Samsung and Honor, go as far as making their own email clients and calendars. 

I recently reviewed the Honor 400 Pro, and one of the big issues I found with that phone was how much unsolicited stuff comes pre-loaded as standard. Third-party apps from TikTok, LinkedIn, WPS office, Temu and a variety of others are all there as soon as you turn it on for the first time, making the phone feel cluttered, bloated and complicated before you’ve even had a chance to install one app of your own. The Pixel has none of this.

It’s the same with AI tools. Samsung has its Bixby assistant, plus a huge variety of its own AI functions. The Honor 400 Pro packs a bunch of AI features for real-time translation and transcription, as do the OnePlus 13 and various other recent Android phones. But they all come with Google’s Gemini Advanced, too, along with Circle to Search. The Pixel doesn’t need to pointlessly double up. If you want to use AI with your phone, its tools are baked into the heart of the phone experience without you needing to also activate and sign into a third-party service.

This simple approach extends to the camera, too. Open the default camera app and you’re met with a neat interface, comprised mostly of the shutter button and zoom levels, with other shooting modes found alongside. It doesn’t try to overcomplicate things here, instead letting you quickly shoot images without messing about with settings. 

It’s an approach that works here, and as a result, the Pixel 9 Pro takes some of my favorite automatic images from a phone camera, doing a great job of balancing exposure and colors. I love the Xiaomi 15 Ultra’s camera, but to get the best from it, you need to shoot in Pro mode, taking manual control of the settings, which makes it more suited to advanced photographers who want to fine-tune their images. 

The Pixel does offer deeper control if you want it, conveniently hidden behind a small settings icon, rather than requiring you to switch completely into a «Pro» mode. For those of you wanting to take manual control of your white balance to warm up a beautiful sunset, the Pixel 9 Pro offers an easy way in.

The specs

  • 6.3-inch LTPO OLED display, 2,856×1,280 pixel resolution, 1-120Hz adaptive refresh rate
  • Google Tensor G4 processor
  • 16GB RAM
  • 4,700-mAh battery
  • 50 megapixel main camera, 48 megapixel ultrawide, 48 megapixel telephoto zoom

CNET’s key takeaways

CNET’s buying advice

Google has clearly taken notes from Apple’s approach in making the Pixel range. Apple’s phones may be derided by Android fans for their lack of customization and «locked down» nature, but iPhones are famously more simple to operate. They have integrated hardware, software and services that make them easy to understand whether you’re new to smartphones or a veteran gadget obsessive. 

Apple’s «you do things our way» approach is a big part of the phone’s success, and the Pixel 9 Pro feels like the closest approximation of the Apple experience you can find on Android. If you’re looking for a clean experience with a smartphone that doesn’t try and get in your way with needless extras, the Pixel 9 Pro is certainly worth a look.

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