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Woolly mammoths could again walk the Earth in just a few years

Colossal lands $15 million to restore the woolly mammoth to the Arctic. The CRIPSR startup thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bring the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene-editing technology.

The plan isn’t to re-create true woolly mammoths, but instead to bring their cold-adapted genetic traits, which include small ears and more body fat, to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet, too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

There are other ways Colossal hopes to help. Its gene editing technology could artificially add genetic diversity to species with only small surviving populations, Lamm said.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent protecting ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

Today’s NYT Mini Crossword Answers for Tuesday, Oct. 14

Here are the answers for The New York Times Mini Crossword for Oct. 14.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.


Today’s Mini Crossword has an odd vertical shape, with an extra Across clue, and only four Down clues. The clues are not terribly difficult, but one or two could be tricky. Read on if you need the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: Smokes, informally
Answer: CIGS

5A clue: «Don’t have ___, man!» (Bart Simpson catchphrase)
Answer: ACOW

6A clue: What the vehicle in «lane one» of this crossword is winning?
Answer: RACE

7A clue: Pitt of Hollywood
Answer: BRAD

8A clue: «Yeah, whatever»
Answer: SURE

9A clue: Rd. crossers
Answer: STS

Mini down clues and answers

1D clue: Things to «load» before a marathon
Answer: CARBS

2D clue: Mythical figure who inspired the idiom «fly too close to the sun»
Answer: ICARUS

3D clue: Zoomer around a small track
Answer: GOCART

4D clue: Neighbors of Norwegians
Answer: SWEDES

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New California Law Wants Companion Chatbots to Tell Kids to Take Breaks

Gov. Gavin Newsom signed the new requirements on AI companions into law on Monday.

AI companion chatbots will have to remind users in California that they’re not human under a new law signed Monday by Gov. Gavin Newsom.

The law, SB 243, also requires companion chatbot companies to maintain protocols for identifying and addressing cases in which users express suicidal ideation or self-harm. For users under 18, chatbots will have to provide a notification at least every three hours that reminds users to take a break and that the bot is not human.

It’s one of several bills Newsom has signed in recent weeks dealing with social media, artificial intelligence and other consumer technology issues. Another bill signed Monday, AB 56, requires warning labels on social media platforms, similar to those required for tobacco products. Last week, Newsom signed measures requiring internet browsers to make it easy for people to tell websites they don’t want them to sell their data and banning loud advertisements on streaming platforms. 

AI companion chatbots have drawn particular scrutiny from lawmakers and regulators in recent months. The Federal Trade Commission launched an investigation into several companies in response to complaints by consumer groups and parents that the bots were harming children’s mental health. OpenAI introduced new parental controls and other guardrails in its popular ChatGPT platform after the company was sued by parents who allege ChatGPT contributed to their teen son’s suicide. 

«We’ve seen some truly horrific and tragic examples of young people harmed by unregulated tech, and we won’t stand by while companies continue without necessary limits and accountability,» Newsom said in a statement.


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One AI companion developer, Replika, told CNET that it already has protocols to detect self-harm as required by the new law, and that it is working with regulators and others to comply with requirements and protect consumers. 

«As one of the pioneers in AI companionship, we recognize our profound responsibility to lead on safety,» Replika’s Minju Song said in an emailed statement. Song said Replika uses content-filtering systems, community guidelines and safety systems that refer users to crisis resources when needed.

Read more: Using AI as a Therapist? Why Professionals Say You Should Think Again

A Character.ai spokesperson said the company «welcomes working with regulators and lawmakers as they develop regulations and legislation for this emerging space, and will comply with laws, including SB 243.» OpenAI spokesperson Jamie Radice called the bill a «meaningful move forward» for AI safety. «By setting clear guardrails, California is helping shape a more responsible approach to AI development and deployment across the country,» Radice said in an email.

One bill Newsom has yet to sign, AB 1064, would go further by prohibiting developers from making companion chatbots available to children unless the AI companion is «not foreseeably capable of» encouraging harmful activities or engaging in sexually explicit interactions, among other things. 

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