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Woolly mammoths could again walk the Earth in just a few years

Colossal lands $15 million to restore the woolly mammoth to the Arctic. The CRIPSR startup thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bring the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene-editing technology.

The plan isn’t to re-create true woolly mammoths, but instead to bring their cold-adapted genetic traits, which include small ears and more body fat, to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet, too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

There are other ways Colossal hopes to help. Its gene editing technology could artificially add genetic diversity to species with only small surviving populations, Lamm said.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent protecting ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Feb. 7, #502

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Feb. 7, No. 502.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.


Today’s Connections: Sports Edition features a fun batch of categories. The purple one requires you to find hidden words inside some of the grid words, but they’re not too obscure. If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Golden Gate.

Green group hint: It’s «Shotime!»

Blue group hint: Same first name.

Purple group hint: Tweak a team name.

Answers for today’s Connections: Sports Edition groups

Yellow group: Bay Area teams.

Green group: Associated with Shohei Ohtani.

Blue group: Coaching Mikes.

Purple group: MLB teams, with the last letter changed.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is Bay Area teams. The four answers are 49ers, Giants, Sharks and Valkyries.

The green words in today’s Connections

The theme is associated with Shohei Ohtani. The four answers are Decoy, Dodgers, Japan and two-way.

The blue words in today’s Connections

The theme is coaching Mikes. The four answers are Macdonald, McCarthy, Tomlin and Vrabel.

The purple words in today’s Connections

The theme is MLB teams, with the last letter changed. The four answers are Angelo (Angels), Cuba (Cubs), redo (Reds) and twine (Twins).

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Technologies

Today’s NYT Mini Crossword Answers for Saturday, Feb. 7

Here are the answers for The New York Times Mini Crossword for Feb. 7

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.


Need some help with today’s Mini Crossword? It’s Saturday, so it’s a long one, and a few of the clues are tricky. Read on for all the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.

Mini across clues and answers

1A clue: Lock lips
Answer: KISS

5A clue: Italian author of «Inferno,» «Purgatorio» and «Paradiso»
Answer: DANTE

6A clue: Cerebral ___ (part of the brain)
Answer: CORTEX

7A clue: Leave home with a stuffed pillowcase as luggage, perhaps
Answer: RUNAWAY

8A clue: No more for me, thanks»
Answer: IMGOOD

9A clue: Fancy fabrics
Answer: SILKS

10A clue: Leg joint
Answer: KNEE

Mini down clues and answers

1D clue: Bars sung in a bar
Answer: KARAOKE

2D clue: How the animals boarded Noah’s Ark
Answer: INTWOS

3D clue: Stand in good ___
Answer: STEAD

4D clue: Smokin’ hot
Answer: SEXY

5D clue: Computer attachment
Answer: DONGLE

6D clue: Yotam Ottolenghi called it «the one spice I could never give up»
Answer: CUMIN

7D clue: Hazard
Answer: RISK

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Technologies

Astronauts Can Now Use the Latest Smartphones in Space

Two upcoming missions could see astronauts using smartphones to capture lunar selfies and more.

Astronauts will now be able to bring modern smartphones on space missions, according to a tweet this week from NASA administrator Jared Isaacman. Isaacman said the policy will begin with SpaceX Crew-12 and Artemis II.

The SpaceX Crew-12 mission is scheduled to launch Feb. 11 and will carry four astronauts to the International Space Station. NASA’s Artemis II mission is expected to launch in March; it will send four astronauts on a 10-day flight that will circle the Moon and return to Earth.

«We are giving our crews the tools to capture special moments for their families and share inspiring images and video with the world,» Isaacman wrote. 

An Apple representative noted in an email to CNET that this was «the first time [the] iPhone has been fully qualified for extended use in orbit and beyond.»

«Until now, astronauts were largely limited to legacy cameras and older imaging equipment,» the spokesperson said.

NASA did not mention specific phone brands or models in its tweet.

Ars Technica reported that space missions currently use 2016 Nikon DSLR and GoPro cameras. 

Photography has played an important role in space missions since the Apollo missions of the 1960s and 1970s. Apollo 11 astronauts, the first humans to step on the moon, captured iconic photographs of their famed July 1969 mission with specially modified Hasselblad cameras.

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