Technologies
CRISPR startup wants to resurrect the woolly mammoth by 2027
Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.
																								
												
												
											You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.
The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.
«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»
It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.
Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.
Artificial wombs and other technology spinoffs
Church said he expects spinoffs from the company’s biotechnology and genetics work.
«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.
One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.
Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.
At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.
Jurassic Park-style tourism? Nope
Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.
But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.
Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.
Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.
One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.
Is species de-extinction a good idea?
There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.
Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.
But is that really the best use of our resources to help the planet? No, some researchers believe.
Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.
But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.
In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.
At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.
Technologies
Chrome Autofill Now Supports Passport, Driver’s License and Vehicle Info
Soon, you’ll never need to remember anything ever again.
														Computer users are accustomed to web browsers autofilling everything from names and addresses to credit card numbers. Now, Google Chrome is adding new enhanced autofill options that allow users to automatically populate fields for passports, driver’s licenses, and their vehicle’s license plate or VIN, Google said in a blog post on Monday.
Desktop users must choose to turn on the feature, which is called enhanced autofill. Otherwise, it stays off. To turn it on, open Chrome, and at the top right of your browser, select more, then settings, then autofill and passwords. Finally, choose enhanced autofill and turn it in.
Google says Chrome now can «better understand complex forms and varied formatting requirements, improving accuracy across the web.» The company also says that enhanced autofill will be «private and secure.»
This enhanced autofill update is available in all languages, and more data options will be supported in the coming months.
A representative for Google said the company had no additional comment.
Don’t miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source.
Chrome is a critical component in Google’s business. The web browser, currently the most popular in the world with a 73% market share, according to GlobalStats, provides the company with valuable user data that it uses to sell advertising. Advertising is how Google makes the majority of its revenues. New features help keep users loyal to Chrome, making it more difficult for them to switch to other browsers, including those from companies like Perplexity and OpenAI.
Technologies
Today’s NYT Connections: Sports Edition Hints and Answers for Nov. 4, #407
Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Nov. 4, No. 407.
														Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.
Today’s Connections: Sports Edition is a tough one. The Connections: Sports Edition puzzle makers will never run out of categories because they have discovered they can just pick one athlete and make a connections group out of four facts about that person. They do that today with the blue category, so if you don’t know that one player, you’re out of luck. If you’re struggling but still want to solve it, read on for hints and the answers.
Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by the Times. It doesn’t show up in the NYT Games app but appears in The Athletic’s own app. Or you can play it for free online.
Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta
Hints for today’s Connections: Sports Edition groups
Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.
Yellow group hint: Get up and go!
Green group hint: College hoops.
Blue group hint: Famous basketball player.
Purple group hint: Not fair, but…
Answers for today’s Connections: Sports Edition groups
Yellow group: Energy.
Green group: Men’s college basketball teams with the most championships.
Blue group: Associated with Damian Lillard.
Purple group: Foul ____.
Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words
What are today’s Connections: Sports Edition answers?
The yellow words in today’s Connections
The theme is energy. The four answers are pep, verve, vigor and zip.
The green words in today’s Connections
The theme is men’s college basketball teams with the most championships. The four answers are Kentucky, UCLA, UCONN and UNC.
The blue words in today’s Connections
The theme is associated with Damian Lillard. The four answers are 0, Dame Time, Trail Blazers and Weber State.
The purple words in today’s Connections
The theme is foul ____. The four answers are out, shot, territory and tip.
Technologies
Today’s NYT Mini Crossword Answers for Tuesday, Nov. 4
Here are the answers for The New York Times Mini Crossword for Nov. 4.
														Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.
Need some help with today’s Mini Crossword? There are a few tricky clues, so read on for the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.
If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.
Read more: Tips and Tricks for Solving The New York Times Mini Crossword
Let’s get to those Mini Crossword clues and answers.
Mini across clues and answers
1A clue: Quickly fall asleep after a long day
Answer: CRASH
6A clue: 1/16 of a pound
Answer: OUNCE
7A clue: Where chess, shampoo and the number zero were invented
Answer: INDIA
8A clue: Uproar
Answer: FUROR
9A clue: Opposite of saved
Answer: SPENT
Mini down clues and answers
1D clue: Fancy hairdos
Answer: COIFS
2D clue: Period preceding a big event
Answer: RUNUP
3D clue: Tennis great Agassi
Answer: ANDRE
4D clue: Descendant of a wealthy family
Answer: SCION
5D clue: Symbol for «like» on Instagram
Answer: HEART
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