Technologies

CRISPR startup wants to resurrect the woolly mammoth by 2027

Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.

The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

You Can Watch an Exclusive Avatar: Fire and Ash Scene on TikTok Right Now

Disney and TikTok partner on an immersive content hub for James Cameron’s latest movie about the alien Na’vi.

If you’re not quite ready to head to the theater to watch Avatar: Fire and Ash, an exclusive scene preview might sell you on the visual spectacle. As part of a new collaboration with the social media giant, Disney is posting snippets of its new movie to its TikTok account.

This scene isn’t part of any trailer and won’t be posted to other social media accounts, making TikTok the only place you can view it — unless you buy a movie ticket. A first look at the new movie’s scenes isn’t the only Avatar-related bonus on the social media platform right now, either. TikTok has partnered with the house of mouse to bring an entire «immersive content hub» to the app.

A special section of TikTok includes quizzes and educational videos that explore the alien world of Pandora shown off in the movies. On TikTok, you can take a personality quiz to find out what Na’vi clan you most closely align with and unlock a special profile picture border to use on your account.

Science and fiction blend together with a series of videos from real doctors who explain the basis for some of Avatar’s world-building. If you want to learn about exoplanets or how realistic the anatomy of the movie’s alien animals is, these videos will feed your brain while still providing entertainment value.

Perhaps the most enticing part of Disney’s latest social media collaboration is the opportunity for fans to win prizes and trips. TikTok creators who make edits with the #TikTokAvatarContest hashtag are entered into a competition to win Avatar merchandise. The biggest winners will be able to take a trip to visual effects studio Wētā Workshop in New Zealand or visit Avatar director James Cameron’s Lightstorm Entertainment Studio in Los Angeles.

Avatar: Fire and Ash is the third installment in director Cameron’s cinematic passion project. While the first Avatar movie was released in 2009, Cameron didn’t release another entry in the franchise until 2022. In total, there is a five-movie arc planned for the indigo alien Na’vi on the moon of Pandora.

The Avatar movies are known for pushing the boundaries of CGI visual effects in cinema. They are also historically big winners at the box office: the original Avatar is the highest-grossing film of all time, earning $2.9 billion across its theatrical releases. Its sequel, Avatar: The Way of Water, is the third-highest-grossing film of all time, trailing Avengers: Endgame. You can stream those movies on Disney Plus.

It remains to be seen whether Avatar: Fire and Ash will financially live up to its predecessors. The film currently has mixed reviews from critics on Rotten Tomatoes.

Technologies

Brain-Inspired Algorithms Could Dramatically Cut AI Energy Use

A new study dives into a major redesign for AI architecture.

One major issue facing artificial intelligence is the interaction between a computer’s memory and its processing capabilities. When an algorithm is in operation, data flows rapidly between these two components. However, AI models rely on a vast amount of data, which creates a bottleneck.

A new study, published on Monday in the journal Frontiers in Science by Purdue University and the Georgia Institute of Technology, suggests a novel approach to building computer architecture for AI models using brain-inspired algorithms. The researchers say that creating algorithms in this manner could reduce the energy costs associated with AI models.

«Language processing models have grown 5,000-fold in size over the last four years,» Kaushik Roy, a Purdue University computer engineering professor and the study’s lead author, said in a statement. «This alarmingly rapid expansion makes it crucial that AI is as efficient as possible. That means fundamentally rethinking how computers are designed.»

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Most computers today are modeled on an idea from 1945 called the von Neumann architecture, which separates processing and memory. This is where the slowdown occurs. As more people around the world utilize data-hungry AI models, the distinction between a computer’s processing and memory capacity could become a more significant issue.

Researchers at IBM called out this problem in a post earlier this year. The issue computer engineers are running up against is called the ‘memory wall.’

Breaking the memory wall

The memory wall refers to the disparity between memory and processing capabilities. Essentially, computer memory is struggling to keep up with processing speeds. This isn’t a new issue. A pair of researchers from the University of Virginia coined the term back in the 1990s.

But now that AI is prevalent, the memory wall issue is sucking up time and energy in the underlying computers that make AI models work. The paper’s researchers argue that we could try a new computer architecture that integrates memory and processing.

Inspired by how our brains function, the AI algorithms referred to in the paper are known as spiking neural networks. A common criticism of these algorithms in the past is that they can be slow and inaccurate. However, some computer scientists argue that these algorithms have shown significant improvement over the last few years.

The researchers suggest that AI models should utilize a concept related to SNNs, known as compute-in-memory. This concept is still relatively new in the field of AI.

«CIM offers a promising solution to the memory wall problem by integrating computing capabilities directly into the memory system,» the authors write in the paper’s abstract.

Medical devices, transportation, and drones are a few areas where researchers believe improvements could be made if computer processing and memory were integrated into a single system.

«AI is one of the most transformative technologies of the 21st century. However, to move it out of data centers and into the real world, we need to dramatically reduce its energy use,» Tanvi Sharma, co-author and researcher at Purdue University, said in a statement.

«With less data transfer and more efficient processing, AI can fit into small, affordable devices with batteries that last longer,» Sharma said.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Dec. 17, #450

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Dec. 17, No. 450.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition is pretty challenging. How well do you know French soccer? If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Put it on your noggin.

Green group hint: Goes before a division of the year.

Blue group hint: French football.

Purple group hint: Think Louisville Slugger.