Technologies

Regen-COV might work before COVID exposure, trial shows: What to know about monoclonal antibodies

Monoclonal antibodies can greatly reduce hospitalization rates in people most at risk of severe COVID-19.

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

Monoclonal antibody therapy for COVID-19 is available to people in the US for free who are at higher risk of severe disease in the first few days of their illness, or after they’ve been exposed to the coronavirus. The treatment — lab-made antibodies given to a person that help their immune system stop the infection from spreading — has proven to be a key tool for preventing the coronavirus from turning into severe illness. Preliminary research shows the treatment reduces risk for hospitalization or death by about 70%.

Now, early research is showing the treatment may benefit people much earlier on, before they’ve even been exposed to the coronavirus. Regeneron, one of the drug-makers of the antibody treatments, announced Monday that its drug was 81.6% effective in preventing COVID-19 in a trial period of two to eight months post-treatment. The drug in the study, which is called Regen-COV and was given to participants in a series of four injections, is the same drug as the one currently authorized for use on at-risk people who are in the early stages of COVID-19, and on some people who’ve been exposed to it.

Dr. Myron Cohen, who leads the monoclonal antibody efforts for the National Institutes of Health’s COVID Prevention Network, said in a news release Monday that the results from the drug-maker are «particularly important to those who do not respond to COVID-19 vaccines, including people who are immunocompromised.»

Regen-COV isn’t authorized yet for use in anyone who hasn’t been exposed to or is sick with COVID-19. A few monoclonal antibody therapies, including the one made by Regeneron, have emergency use authorization by the US Food and Drug Administration and should be accessible in doctors’ offices or even some state-run clinics, as seen in states such as Florida and Texas.

Importantly, monoclonal antibodies don’t replace the role of the COVID-19 vaccines in preventing hospitalization and death. According to data from August by the US Centers for Disease Control and Prevention, unvaccinated people were more than 11 times more likely to die from COVID-19 and about 6 times more likely to contract COVID-19 than fully vaccinated people.

A large number of Americans could be eligible for monoclonal antibody treatment if they test positive for COVID-19 (a smaller number would be eligible for the treatment without a positive test, and only a confirmed exposure). For example, everyone age 65 or older, people who are overweight, people with heart, liver, or kidney disease and many more would be eligible for the treatment in the early days of their symptoms.

Here’s what we know now about COVID-19 monoclonal antibodies.

What are monoclonal antibodies, and how do they work?

Monoclonal antibodies are lab-made antibodies that work by binding to bacteria, cancer cells or viruses the way natural antibodies do, stopping them from infecting more cells. The first monoclonal antibody therapy was approved more than 30 years ago and has been used for other illnesses, including the Ebola virus.

Monoclonal antibody treatments for COVID-19 are used before a person gets really sick, usually within 10 days of their first symptom, to prevent hospitalization. The treatment is only approved for people who are at risk of getting extremely sick — those who are age 65 or older and those who have «certain medical conditions,» per the FDA. The same treatment isn’t recommended for people who are already hospitalized with COVID-19.

Monoclonal antibody therapy is also authorized if an at-risk person is exposed to COVID-19, but the definition of «at-risk» in this instance, per the FDA, is a little narrower and reserved for people who are at risk because of a medical condition and unvaccinated or not fully protected by the COVID-19 vaccines because of an immunocompromising condition.

I tested positive. How do I know if I’m eligible?

If you come down with the coronavirus and are concerned about how the disease will affect you, contacting your doctor to learn your options and the best line of treatment for you is a good idea. But, in general, this specific treatment is reserved for people who are at risk for severe disease. Most people who are infected with COVID-19 will recover at home without medical help.

The people who test positive for COVID-19 and would be eligible or benefit from monoclonal antibody therapy may also be the same people who are eligible for COVID-19 vaccine boosters because of a medical condition. For those who are at risk of severe COVID-19 and would be eligible for monoclonal antibodies if they test positive (if they’re at least 12 years old and weigh at least 88 pounds) the FDA defines «at risk» under the EUA as:

All people age 65 and older.
People with obesity or those who are overweight (adults with a BMI of more than 25, and children age 12-17 who have a BMI at the 85th percentile or greater).
Pregnant people.
People with cancer.
People with chronic kidney or lung disease.
Individuals with cardiovascular disease or hypertension.
People with diabetes.
People with sickle cell disease.
Those living with neurodevelopmental disorders.
People who are immunocompromised or taking immunocompromising medication.
Those who have a «medical-related technological dependence» (such as a tracheostomy or gastrostomy).

However, the FDA stressed in a fact sheet for Eli Lilly’s treatment (another brand of monoclonal antibodies) that this isn’t a complete list, and other medical conditions or factors including race or ethnicity may also place individuals at higher risk for severe COVID-19. It also pointed to the CDC’s list of «people with certain medical conditions» for other health conditions, which includes things such as depression and Down syndrome as being high-risk conditions.

In sum: If you test positive and feel you are at risk for severe COVID-19 and might qualify for monoclonal antibodies, you should probably speak to a health care professional about them.

Does vaccine status matter?

No, people who test positive for COVID-19 and are eligible for monoclonal antibody therapy because of their age or health condition can be treated regardless of their vaccination status. That is because, while still protective, the vaccines may be less effective at preventing severe disease in some people than others.

However, being unvaccinated might make you eligible for monoclonal antibodies after an exposure to someone with COVID-19. According to the FDA’s authorization of Regen-COV for post-exposure, people eligible for post-exposure treatment must be at risk of severe COVID-19 disease, and either unvaccinated or vaccinated but immunocompromised or taking immunocompromising medications.

I qualify. How do I access the treatment?

Monoclonal antibodies are administered by IV (most commonly) or by injection, so they’re not a prescription you can easily pick up at the pharmacy. According to CNN, the infusion process takes about an hour and patients need to wait a while to be observed for side effects. If you’re at risk for severe COVID-19 and you’ve tested positive or think you have it, ask your doctor where the treatment is available.

If you live in Texas or Florida where there are state-run monoclonal antibody treatment centers, the same eligibility requirements for patients apply. In Florida, this means everyone age 12 and older who is at «high risk for severe illness» can make an appointment and find a monoclonal treatment center at one of the state’s eight locations. In Texas, there are nine antibody infusion centers across the state, but at-risk people need a referral from their doctor.

If you think you qualify for monoclonal antibody treatment but don’t have a health care provider, you can call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585. You can also use this link from the US Department of Health and Human Services antibody therapy finder.

Do monoclonal antibodies interfere with the coronavirus vaccines?

If you were treated with monoclonal antibodies and you haven’t been vaccinated yet, you should wait 90 days after your treatment to make an appointment, according to the CDC. This recommendation is until more is known about how the antibody response from the treatment affects the immune response from getting vaccinated.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

Taylor Swift Is Engaged. Her Post Smashed an Instagram Record

The post broke Instagram’s record for most reposts, but reposts are new to the site. Plus: Memes, and details on her dress, his sweater and that ring.

Nobody is shaking this off: Pop superstar Taylor Swift and Kansas City Chiefs tight end Travis Kelce announced their engagement on Instagram on Tuesday, and the likes exploded like pyrotechnics at a concert. The post broke Instagram’s record for reposts, even though, to be fair, reposting just started on Instagram in August. Still, the post hit 1 million reposts in less than 6 hours and earned 14 million likes in just the first hour. By Tuesday evening, it had topped 21.2 million likes.

«Your English teacher and your gym teacher are getting married,» Swift and Kelce wrote on an Instagram post showing multiple photos of the proposal. In the first photo, Kelce is kneeling in front of Swift in a breathtaking floral garden. The second photo shows them standing and holding one another. The next is her hand with an enormous diamond engagement ring, followed by two more of the couple embracing.

The post also features a dynamite emoji and the audio of Swift’s 2024 song So High School. The snippet cuts off with the lyrics, «Are you gonna marry, kiss, or kill me?» (Let’s hope it’s the first or second option.)

Instagram post is already climbing into the millions

As you might expect, the Instagram post delivering the engagement news shot into the stratosphere as soon as it was posted on Tuesday. A representative for Instagram confirmed to CNET that Swift and Kelce’s engagement announcement earned over 14 million likes and 452,000 reposts in just over an hour, reaching 21.2 million by 5 p.m. PT Tuesday.

That’s a huge audience, but it will be interesting to see how high up Swift and Kelce’s engagement news post lands on Instagram’s all-time most popular list.

Right now, the most popular post ever on Instagram is from 2022, when soccer star Lionel Messi posted an image of himself hoisting the just-won World Cup. That post has more than 74 million likes. (Swifties, keep it going if you want to send that post to the top.)

The Instagram representative didn’t immediately comment on whether Swift and Kelce’s post is climbing at the same pace as Messi’s. Messi also has the third-most popular post, again showing him and the World Cup trophy, this time snuggled up in bed together.

But it’s not just soccer photos that top the Instagram most-viewed-ever list. The second most-liked post of all time is a photo of a plain, ordinary egg, posted to the social network back in 2019 as part of someone’s experiment to see if such a mundane image could go hugely viral. I interviewed the person behind Eugene the Egg back in 2019 and am shocked to see it’s still in the No. 2 spot six years later, with more than 60 million likes.

As of Tuesday evening, the post’s 21.2 million likes put it just outside the top 20 list of most-liked, non-soccer posts, just behind post No. 20, singer Billie Eilish’s 2021 reveal of her then-new blond hair. Eilish’s post is at 21.9 million likes and could easily fall off the list and be replaced by Swift and Kelce.

Details on the ring and outfits

According to The New York Post, Swift is wearing a blue silk-blend Polo Ralph Lauren dress in the photo, and Kelce is wearing a navy cable-knit Polo Ralph Lauren sweater. The Post also reports that Swift’s new engagement ring is «an old mine brilliant-cut diamond in a gold bezel setting, which was designed by Kelce himself with the help of Kindred Lubeck of Artifex Fine Jewelry.»

Old mine refers to a historic diamond cut popular from the early 18th century to the late 19th century. Such diamonds are square with rounded corners and have 58 facets, making them anything but a «paper ring.»

The Post delved into everything else Swift had on, including her cognac-colored Louis Vuitton sandals, $18,000 diamond-studded Cartier Santos Demoiselle watch and her «TNT» friendship bracelet by Wove, which was a Christmas gift from her new fiancé.

To no one’s shock, the $400 dress Swift is wearing is selling out fast. Just imagine the excitement when the wedding details start trickling out, and Swift begins to «pick out a white dress,» as Juliet does in Swift’s hit song Love Story.

Memeing the marriage proposal

Until we have more information about the upcoming wedding, fans will have to content themselves by creating and sharing memes because, well, it’s 2025, and that’s part of how we communicate these days.

The Instagram account belonging to the Prince and Princess of Wales even liked the post. (No surprise, really, they hung out when Swift played London.)

Even coffee giant Starbucks got into the act, making a joke about pumpkin spice lattes and posting, «Are we supposed to keep posting about PSL like nothing happened?» The company also noted in the post’s comments that «the long list of Starbucks lovers just got a +1.» («Starbucks lovers» is a sly reference to a lyric in Swift’s 2014 song Blank Space. Swift actually sings, «got a long list of ex-lovers,» but almost anyone with working ears mishears it as something like, «all the lonely Starbucks lovers.»

One meme post on X showed Paul Revere’s famed ride, captioned «me telling everyone I know that Taylor Swift got engaged.»

me telling everyone I know that Taylor Swift got engaged pic.twitter.com/MpS8BLPOZj

— Siobhan ✨ (@Siobachka) August 26, 2025

One Bluesky user wrote, «Very interesting that Taylor Swift got engaged mere months after I did. Get your own thing.»

Another joked, «Can’t believe that on July 8th, 2023, @likethe309, Travis Kelce and I all walked into Arrowhead Stadium to attend the Eras Tour and now one of us is marrying Taylor Swift.»

Matt Ufford warned the billionaire bride-to-be and her NFL star husband to count their pennies, writing, «a word of warning to Taylor Swift and Travis Kelce: weddings can get EXPENSIVE, fast, be sure to leave enough in the account for your monthly expenses.»

There were football jokes, of course.

The Detroit Free Press sought a local connection, using the headline, «Tight end for Detroit Lions’ Week 6 opponent gets engaged to Taylor Swift.»

One person questioned the caption about an English teacher marrying a gym teacher, asking, «Why does Taylor Swift think she’s an English teacher and not a music teacher?»

We’re pretty sure this person really does know who Swift is, but their post was funny anyway. It reads, «Okay, I’ll bite: who’s Taylor Swift? What’s so great about him?»

The two 35-year-old celebrities have been dating for two years. It’s a love story, and Taylor just said yes.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Aug. 27, #338

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Aug. 27, No. 338

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition features a lot of names, and I tend to do terribly on those puzzles. I do even worse when the puzzle editors change a letter in a bunch of names, as they did today. So I did terribly. But you can still solve the puzzle! Read on for hints and the answers.

Connections: Sports Edition is out of beta now, making its debut on Super Bowl Sunday, Feb. 9. That’s a sign that the game has earned enough loyal players that The Athletic, the subscription-based sports journalism site owned by the Times, will continue to publish it. It doesn’t show up in the NYT Games app but now appears in The Athletic’s own app. Or you can continue to play it free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Call a nurse.

Green group hint: Sports shirt.

Blue group hint: Hoops heroes.

Purple group hint: Signal callers, with a twist.

Answers for today’s Connections: Sports Edition groups

Yellow group: Get better.

Green group: Found on a soccer jersey.

Blue group: 2025 Naismith basketball HOF class.

Purple group: Hall of Fame QBs, with the last letter changed.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is get better. The four answers are heal, mend, recover and recuperate.

The green words in today’s Connections

The theme is found on a soccer jersey. The four answers are crest, name, number and sponsor.

The blue words in today’s Connections

The theme is 2025 Naismith basketball HOF class. The four answers are Anthony, Bird, Fowles and Moore.

The purple words in today’s Connections

The theme is Hall of Fame QBs, with the last letter changed. The four answers are Marine (Dan Marino), Moor (Warren Moon), Stables (Ken Stabler) and Warned (Kurt Warner).

Technologies

Today’s NYT Mini Crossword Answers for Wednesday, Aug. 27

Here are the answers for The New York Times Mini Crossword for Aug. 27.

Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.

Today’s Mini Crossword might be the toughest one I’ve ever done! Hint: There’s a trick to it. Not all the words are spelled quite as they seem. Try solving the Down clues first if you get stuck on the Across ones. Need answers? Read on. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.

If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.

Read more: Tips and Tricks for Solving The New York Times Mini Crossword

Let’s get to those Mini Crossword clues and answers.