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Regen-COV might work before COVID exposure, trial shows: What to know about monoclonal antibodies

Monoclonal antibodies can greatly reduce hospitalization rates in people most at risk of severe COVID-19.
For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

Monoclonal antibody therapy for COVID-19 is available to people in the US for free who are at higher risk of severe disease in the first few days of their illness, or after they’ve been exposed to the coronavirus. The treatment — lab-made antibodies given to a person that help their immune system stop the infection from spreading — has proven to be a key tool for preventing the coronavirus from turning into severe illness. Preliminary research shows the treatment reduces risk for hospitalization or death by about 70%.

Now, early research is showing the treatment may benefit people much earlier on, before they’ve even been exposed to the coronavirus. Regeneron, one of the drug-makers of the antibody treatments, announced Monday that its drug was 81.6% effective in preventing COVID-19 in a trial period of two to eight months post-treatment. The drug in the study, which is called Regen-COV and was given to participants in a series of four injections, is the same drug as the one currently authorized for use on at-risk people who are in the early stages of COVID-19, and on some people who’ve been exposed to it.

Dr. Myron Cohen, who leads the monoclonal antibody efforts for the National Institutes of Health’s COVID Prevention Network, said in a news release Monday that the results from the drug-maker are «particularly important to those who do not respond to COVID-19 vaccines, including people who are immunocompromised.»

Regen-COV isn’t authorized yet for use in anyone who hasn’t been exposed to or is sick with COVID-19. A few monoclonal antibody therapies, including the one made by Regeneron, have emergency use authorization by the US Food and Drug Administration and should be accessible in doctors’ offices or even some state-run clinics, as seen in states such as Florida and Texas.

Importantly, monoclonal antibodies don’t replace the role of the COVID-19 vaccines in preventing hospitalization and death. According to data from August by the US Centers for Disease Control and Prevention, unvaccinated people were more than 11 times more likely to die from COVID-19 and about 6 times more likely to contract COVID-19 than fully vaccinated people.

A large number of Americans could be eligible for monoclonal antibody treatment if they test positive for COVID-19 (a smaller number would be eligible for the treatment without a positive test, and only a confirmed exposure). For example, everyone age 65 or older, people who are overweight, people with heart, liver, or kidney disease and many more would be eligible for the treatment in the early days of their symptoms.

Here’s what we know now about COVID-19 monoclonal antibodies.

What are monoclonal antibodies, and how do they work?

Monoclonal antibodies are lab-made antibodies that work by binding to bacteria, cancer cells or viruses the way natural antibodies do, stopping them from infecting more cells. The first monoclonal antibody therapy was approved more than 30 years ago and has been used for other illnesses, including the Ebola virus.

Monoclonal antibody treatments for COVID-19 are used before a person gets really sick, usually within 10 days of their first symptom, to prevent hospitalization. The treatment is only approved for people who are at risk of getting extremely sick — those who are age 65 or older and those who have «certain medical conditions,» per the FDA. The same treatment isn’t recommended for people who are already hospitalized with COVID-19.

Monoclonal antibody therapy is also authorized if an at-risk person is exposed to COVID-19, but the definition of «at-risk» in this instance, per the FDA, is a little narrower and reserved for people who are at risk because of a medical condition and unvaccinated or not fully protected by the COVID-19 vaccines because of an immunocompromising condition.

Read more: Pfizer says its COVID-19 antiviral pill reduces risk of serious illness

I tested positive. How do I know if I’m eligible?

If you come down with the coronavirus and are concerned about how the disease will affect you, contacting your doctor to learn your options and the best line of treatment for you is a good idea. But, in general, this specific treatment is reserved for people who are at risk for severe disease. Most people who are infected with COVID-19 will recover at home without medical help.

The people who test positive for COVID-19 and would be eligible or benefit from monoclonal antibody therapy may also be the same people who are eligible for COVID-19 vaccine boosters because of a medical condition. For those who are at risk of severe COVID-19 and would be eligible for monoclonal antibodies if they test positive (if they’re at least 12 years old and weigh at least 88 pounds) the FDA defines «at risk» under the EUA as:

  • All people age 65 and older.
  • People with obesity or those who are overweight (adults with a BMI of more than 25, and children age 12-17 who have a BMI at the 85th percentile or greater).
  • Pregnant people.
  • People with cancer.
  • People with chronic kidney or lung disease.
  • Individuals with cardiovascular disease or hypertension.
  • People with diabetes.
  • People with sickle cell disease.
  • Those living with neurodevelopmental disorders.
  • People who are immunocompromised or taking immunocompromising medication.
  • Those who have a «medical-related technological dependence» (such as a tracheostomy or gastrostomy).

However, the FDA stressed in a fact sheet for Eli Lilly’s treatment (another brand of monoclonal antibodies) that this isn’t a complete list, and other medical conditions or factors including race or ethnicity may also place individuals at higher risk for severe COVID-19. It also pointed to the CDC’s list of «people with certain medical conditions» for other health conditions, which includes things such as depression and Down syndrome as being high-risk conditions.

In sum: If you test positive and feel you are at risk for severe COVID-19 and might qualify for monoclonal antibodies, you should probably speak to a health care professional about them.

Does vaccine status matter?

No, people who test positive for COVID-19 and are eligible for monoclonal antibody therapy because of their age or health condition can be treated regardless of their vaccination status. That is because, while still protective, the vaccines may be less effective at preventing severe disease in some people than others.

However, being unvaccinated might make you eligible for monoclonal antibodies after an exposure to someone with COVID-19. According to the FDA’s authorization of Regen-COV for post-exposure, people eligible for post-exposure treatment must be at risk of severe COVID-19 disease, and either unvaccinated or vaccinated but immunocompromised or taking immunocompromising medications.

I qualify. How do I access the treatment?

Monoclonal antibodies are administered by IV (most commonly) or by injection, so they’re not a prescription you can easily pick up at the pharmacy. According to CNN, the infusion process takes about an hour and patients need to wait a while to be observed for side effects. If you’re at risk for severe COVID-19 and you’ve tested positive or think you have it, ask your doctor where the treatment is available.

If you live in Texas or Florida where there are state-run monoclonal antibody treatment centers, the same eligibility requirements for patients apply. In Florida, this means everyone age 12 and older who is at «high risk for severe illness» can make an appointment and find a monoclonal treatment center at one of the state’s eight locations. In Texas, there are nine antibody infusion centers across the state, but at-risk people need a referral from their doctor.

If you think you qualify for monoclonal antibody treatment but don’t have a health care provider, you can call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585. You can also use this link from the US Department of Health and Human Services antibody therapy finder.

Do monoclonal antibodies interfere with the coronavirus vaccines?

If you were treated with monoclonal antibodies and you haven’t been vaccinated yet, you should wait 90 days after your treatment to make an appointment, according to the CDC. This recommendation is until more is known about how the antibody response from the treatment affects the immune response from getting vaccinated.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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Signal Will Black Out Windows Recall Screenshots to Preserve Privacy

It’s a whole different kind of dark mode for the paparazzi-like AI feature in Windows 11.

The privacy-minded Signal messaging service is putting a blindfold on the prying eyes of the newly returned Windows Recall, Microsoft’s AI-powered feature that will take a screenshot of whatever you’re doing on your computer every few seconds to give your PC the «photographic memory» you never asked for.

In a blog post Wednesday, Signal announced a new «screen security» feature for its Windows 11 app so that said screenshots will appear as a black screen when it tries to snap what you’re doing, much like what happens if you try to take a screenshot of DRM content from Netflix and the like.

Last year, Microsoft pulled Recall from new Copilot Plus PCs in response to backlash over security and privacy concerns, which continued to plague it in the ensuing months as Microsoft worked through revisions. 

Neither Signal nor Microsoft immediately responded to a request for comment. 

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Technologies

I’ve Been Tracking Tariff Price Impacts Every Day: Some Are Steady, But Don’t Get Comfy

CNET is keeping track of prices for several key products as prospects for the months ahead remain uncertain.

Amazon this week claimed that is prices were remaining steady, but the news about President Donald Trump’s tariffs and the economic fallout isn’t getting any rosier: Just this week, Subaru announced that prices on certain models were getting hiked soon. While the Japanese firm didn’t explicitly call out tariffs as the reason, the fact that the increases were only coming for the US market was telling.

This followed on the heels of perhaps the largest retailer to issue a price increase warning: Walmart. During a May 15 earnings call, the country’s largest grocery chain said that prices for things like toys, tech and food would be going up by the summer. This prompted a response from Trump, who demanded that Walmart not increase prices and eat the costs themselves. This wouldn’t be the first time that the president has lashed out against a company for potentially telling the truth about his tariff’s inflating prices — which, as I’ve written about extensively here on CNET, is absolutely the case.

In this article, I’ve been tracking just that: the daily effect of Trump’s tariffs on the prices of 11 popular products you might want or need to buy, whether it be a new phone, laptop or your daily coffee. So far, we’ve seen notable price hikes for the flagship Xbox game console, while everything else has, as Amazon claimed, remained steady aside from occasional fluctuations that might not be tariff-related. That sort of consistency is far from certain, however, especially with new reports emerging that Apple might be looking to make iPhones more expensive this year.

CNET Tariff Tracker Index

Above, you can check out a chart with the average price of the 11 included items over the course of 2025. This will help give you a sense of the overall price changes and fluctuations going on. Further down, you’ll be able to check out charts for each individual product being tracked.

A recent tariff agreement with China, much-hyped by the White House, did significantly cut tariff rates against the US’s biggest trading partner. The new 30% rate is only temporary, however, and still historically high. It just looks more reasonable next to the ludicrous 145% rate that was previously in place. As those negotiations move along, companies continue to warn of impending price hikes in order to deal with the new tariffs, including Sony, which could potentially mean a price hike for its ever-popular PlayStation 5 consoles.

We’ll be updating this article regularly as prices change. It’s all in the name of helping you make sense of things, so be sure to check back every so often. For more, check out CNET’s guide to whether you should wait to make big purchases or buy them now and get expert tips about how to prepare for a recession.

Methodology

We’re checking prices daily and will update the article and the relevant charts right away to reflect any changes. The following charts show a single bullet point for each month, with the most recent one labeled «Now» and showing the current price. For the past months, we’ve gone with what was the most common price for each item in the given month. 

In most cases, the price stats used in these graphs were pulled from Amazon using the historical price tracker tool Keepa. For the iPhones, the prices come from Apple’s official materials and are based on the 128-gigabyte base model of the latest offering for each year: the iPhone 14, iPhone 15 and iPhone 16. For the Xbox Series X, the prices were sourced from Best Buy using the tool PriceTracker. If any of these products happen to be on sale at a given time, we’ll be sure to let you know and explain how those price drops differ from longer-term pricing trends that tariffs can cause.

The 11 products we’re tracking

Mostly what we’re tracking in this article are electronic devices and digital items that CNET covers in depth, like iPhones and affordable 4K TVs — along with a typical bag of coffee, a more humble product that isn’t produced in the US to any significant degree. 

The products featured were chosen for a few reasons: Some of them are popular and/or affordable representatives for major consumer tech categories, like smartphones, TVs and game consoles. Others are meant to represent things that consumers might buy more frequently, like printer ink or coffee beans. Some products were chosen over others because they are likely more susceptible to tariffs. Some of these products have been reviewed by CNET or have been featured in some of our best lists.

Below, we’ll get into more about each individual product.

iPhone 16

The iPhone is the most popular smartphone brand in the US, so this was a clear priority for price tracking. The iPhone has also emerged as a major focal point for conversations about tariffs, given its popularity and its susceptibility to import taxes because of its overseas production, largely in China. Trump has reportedly been fixated on the idea that the iPhone can and should be manufactured in the US, an idea that experts have dismissed as a fantasy. Estimates have also suggested that a US-made iPhone would cost as much as $3,500.

Apple has made several moves this year to protect its prices in the US as much as possible, like flying in bulk shipments of product ahead of the tariffs taking effect and working to move production for the American market from China to India, where tariff rates are less severe. This latter move provoked a response from Trump, given his noted fixation on the iPhone, saying on Thursday that he «had a little problem» with Tim Cook over the move, claiming without evidence that the Apple CEO pledged to bring more manufacturing to the US. Cook and others close to the company for years say that the supply chains for its products are too complex to move manufacturing entirely to the US.

Duracell AA batteries

A lot of the tech products in your home might boast a rechargeable energy source but individual batteries are still an everyday essential and I can tell you from experience that as soon as you forget about them, you’ll be needing to restock. The Duracell AAs we’re tracking are some of the bestselling batteries on Amazon.

Samsung DU7200 TV

Alongside smartphones, televisions are some of the most popular tech products out there, even if they’re an infrequent purchase. This particular product is a popular entry-level 4K TV and was CNET’s pick for best overall budget TV for 2025. Unlike a lot of tech products that have key supply lines in China, Samsung is a South Korean company, so it might have some measure of tariff resistance. 

Xbox Series X

Video game software and hardware are a market segment expected to be hit hard by the Trump tariffs. Microsoft’s Xbox is the first console brand to see price hikes — the company cited «market conditions» along with the rising cost of development. Most notably, this included an increase in the price of the flagship Xbox Series X, up from $500 to $600. Numerous Xbox accessories were also affected, and the company also said that «certain» games will eventually see a price hike from $70 to $80.

Initially, we were tracking the price of the much more popular Nintendo Switch as a representative of the gaming market. Nintendo has not yet hiked the price of its handheld-console hybrid and stressed that the $450 price tag of the upcoming Switch 2 has not yet been inflated because of tariffs. Sony, meanwhile, has so far only increased prices on its PlayStation hardware in markets outside the US.

AirPods Pro 2

The latest iteration of Apple’s wildly popular true-wireless earbuds are here to represent the headphone market. Much to the chagrin of the audiophiles out there, a quick look at sales charts on Amazon shows you just how much the brand dominates all headphone sales. 

HP 962 CMY printer ink

This HP printer ink includes cyan, magenta and yellow all in one product and recently saw its price jump from around $72 — where it stayed for most of 2025 — to $80, which is around its highest price over the last five years. We will be keeping tabs to see if this is a long-term change or a brief uptick.

This product replaced Overture PLA Filament for 3D printers in this piece, but we’re still tracking that item.

Anker 10,000-mAh, 30-watt power bank

Anker’s accessories are perennially popular in the tech space and the company has already announced that some of its products will get more expensive as a direct result of tariffs. This specific product has also been featured in some of CNET’s lists of the best portable chargers. While the price has remained steady throughout the year, it is currently on sale for $16 on Amazon, but only for Prime members.

Bose TV speaker

Soundbars have become important purchases, given the often iffy quality of the speakers built into TVs. While not the biggest or the best offering in the space, the Bose TV Speaker is one of the more affordable soundbar options out there, especially hailing from a brand as popular as Bose.

Oral-B Pro 1000 electric toothbrush

They might be a lot more expensive than their traditional counterparts, but electric toothbrushes remain a popular choice for consumers because of how well they get the job done. I know my dentist won’t let up on how much I need one. This particular Oral-B offering was CNET’s overall choice for the best electric toothbrush for 2025.

Lenovo IdeaPad Flex 5i Chromebook

Lenovo is notable among the big laptop manufacturers for being a Chinese company making its products especially susceptible to Trump’s tariffs.

Starbucks Ground Coffee (28-ounce bag)

Coffee is included in this tracker because of its ubiquity —I’m certainly drinking too much of it these days —and because it’s uniquely susceptible to Trump’s tariff agenda. Famously, coffee beans can only be grown within a certain distance from Earth’s equator, a tropical span largely outside the US and known as the «Coffee Belt.» 

Hawaii is the only part of the US that can produce coffee beans, with data from USAFacts showing that 11.5 million pounds were harvested there in the 2022-23 season — little more than a drop in the mug, as the US consumed 282 times that amount of coffee during that period. Making matters worse, Hawaiian coffee production has declined in the past few years.

All that to say: Americans get almost all of their coffee from overseas, making it one of the most likely products to see price hikes from tariffs.

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I Tested the Honor 400 Pro Phone and This Feature Blew My Mind

Review: The phone is packed with great tech but it’s the AI skills that really surprised me

The Honor 400 Pro phone stood out to me for one big reason during my testing time. It has an AI-powered tool that turns still images into moving video clips. The AI created videos felt at times like magic and took me on an emotional journey that I didn’t expect. But this phone has plenty going for it beyond its AI skills. 

Its screen is bright and vibrant, it’s packed with power and at £700 in the UK, it’s relatively affordable and offers some serious competition to both Samsung’s $650 Galaxy S24 FE and arguably even Google’s $1,000 Pixel 9 Pro. The downside for many of you is that the Honor 400 Pro won’t be officially on sale in the US. And that’s a pity because at a time when nearly every phone release comes with AI features (most of which feel like gimmicks), Honor proves that it’s possible for phone AI to really capture your attention. The 400 Pro’s £700 price converts to $938.

There’s also the base Honor 400, which uses a lower-end processor, has a smaller display but still packs the same AI skills. It’ll cost only £400 in the UK, or $537, converted.

I’ve been testing the phone for the past week so here’s what’s good — and not so good — about the Honor 400 Pro. 

A vibrant screen, plenty of power

The 400 Pro has a 6.7-inch screen that offers tons of room to do your favorite mobile games or YouTube videos justice. It’s bright enough to counter midday sun and its colors are vibrant. It’s got a maximum 120Hz refresh rate, which makes scrolling around look nice and smooth. 

The phone runs on a Qualcomm Snapdragon 8 Gen 3 processor that was a mainstay on most 2024 flagship Android phones and which put in some decent scores on our benchmark tests, considering the price. Its scores are in line with last year’s Galaxy S24 and Xiaomi 14 Ultra, which is no surprise as all three phones use the same chip. It’s got more than enough power to handle all of your everyday needs while tackling demanding games like Genshin Impact and PUBG at max settings without breaking a sweat.

Navigating around the Android 15 interface is a breeze. Honor’s skin of the UI is pretty standard, though I’m irked by the number of preinstalled apps the phone comes with. Temu, TikTok, LinkedIn, Booking.com, Amazon and something called ReelShort are all on the phone — along with various others — as soon as you turn it on making it feel quite cluttered from the off. I get that Honor probably makes a healthy bit of cash from these companies by forcing their apps on customers by default, but I’d like to see the phone be even cheaper given that it’s essentially ad-supported. You can uninstall these apps and I advise you to have an immediate clear-out once you get it out of the box. 

Honor says the phone will receive six years of software and security support, which is quite good, though it’s a year behind the seven years of security support offered by both Samsung and Google. I’d like to see Honor (and other mobile companies) continue to battle to see who can support their phones for longer — it’s better for your wallet and it’s better for the planet.

AI. Lots of AI

No phone worth its salt in 2025 would launch without some form of AI, and the Honor 400 Pro is no exception. You’ll find a variety of the usual AI tools that range from a speech-to-text tool that transcribes dialogue in real time and a real-time language translation tool to a function that can rephrase, expand or summarise blocks of text. 

Most of these are things you’ll find on most AI-enabled phones these days. They work about as well as the ones I’ve tried elsewhere. Google’s Gemini Advanced is also built in, another standard part of the Android experience.

The one feature that took me by surprise though was the image to video tool which creates a 5-second video out of a photo you provide. It’s simple: Open the Image to Video tool in the gallery, choose your source image from your camera roll and hit go. It takes around a minute but then you’ll be presented with an animated version of your still photo.

It uses Google’s VEO-2 AI model, and it seems essentially random in how it decides to bring your image to life as there are no options to provide prompts in what you want to see. Some results are quite bland while others have a lot more going on. The results can be hit and miss in their quality but it’s fun to play around with, though it’s arguably pointless beyond the sheer novelty of it. That said, I was conflicted when I fed it an image of my dad who died when I was a young child. 

Right now the tool is available as part of a «free trial» although Honor has yet to confirm how long this trial lasts or how much it will eventually cost. AI is clearly a big part of the phone and while you can use it without using any of the AI tools, it feels like you’d be missing out on a big part of the equation if you chose to. 

Hit and miss cameras, middling battery

On the back is a triple camera setup consisting of a 200-megapixel main camera (yes, I did mean to put two zeroes there), a 50-megapixel telephoto camera and a 12-megapixel ultrawide camera. Shots from all three cameras can look solid, with decent overall exposure (if sometimes a little on the bright side for my taste) and plenty of detail. I say «can» as while I have taken plenty of good images with the phone, I’ve also taken various ones that have disappointed me. 

The 6x telephoto camera seems to struggle with exposure at times, with blown-out highlights visible in multiple test images I took. It doesn’t happen all the time though and there have been various occasions in my testing when its results look great. I can best describe it as «hit and miss.»

The cameras certainly aren’t the best around — you’ll need to splash more cash for the S25 Ultra or the iPhone 16 Pro if you want that — but they’re good enough for those of you looking for quick snaps on your travels to share with family and friends over WhatsApp or Instagram.

Inside the phone is a 5,300-mAh battery which should see you through most of a day of mixed use. It didn’t do great on our demanding battery drain test, but I’ve certainly seen worse. It does support 100W wired charging though so getting the juice back in is a speedy business. 

Honor 400 Pro: Is it worth buying?

The phone’s vibrant display, powerful processor and solid camera setup make it a decent overall option if you’re looking for a phone that’s more affordable than today’s flagships. The AI skills are the cherry on the top, especially the image to video tool which I found genuinely fascinating to use. Will the novelty wear off? Yes, absolutely, but it’s certainly fun to play with for a while. 

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