Technologies
CRISPR startup wants to resurrect the woolly mammoth by 2027
Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.
You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.
The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.
«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»
It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.
Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.
Artificial wombs and other technology spinoffs
Church said he expects spinoffs from the company’s biotechnology and genetics work.
«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.
One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.
Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.
At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.
Jurassic Park-style tourism? Nope
Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.
But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.
Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.
Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.
One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.
Is species de-extinction a good idea?
There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.
Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.
But is that really the best use of our resources to help the planet? No, some researchers believe.
Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.
But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.
In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.
At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.
Technologies
Today’s NYT Connections Hints, Answers and Help for Nov. 30, #903
Here are some hints and the answers for the NYT Connections puzzle for Nov. 30, #903.
Looking for the most recent Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles.
Today’s NYT Connections puzzle has one of those purple categories where you need to look inside of the words for hidden words that relate to each other. If you need help sorting them into groups, you’re in the right place. Read on for clues and today’s Connections answers.
The Times now has a Connections Bot, like the one for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. Players who are registered with the Times Games section can now nerd out by following their progress, including the number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak.
Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time
Hints for today’s Connections groups
Here are four hints for the groupings in today’s Connections puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.
Yellow group hint: Put up with.
Green group hint: Bad ending.
Blue group hint: Yo-ho-ho!
Purple group hint: Think rainbow.
Answers for today’s Connections groups
Yellow group: Tolerate.
Green group: Flop.
Blue group: Fictional pirates.
Purple group: Ending in color homophones.
Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words
What are today’s Connections answers?
The yellow words in today’s Connections
The theme is tolerate. The four answers are bear, stand, stomach and swallow.
The green words in today’s Connections
The theme is flop. The four answers are bust, lemon, miss and turkey.
The blue words in today’s Connections
The theme is fictional pirates. The four answers are Hook, Luffy, Silver and Sparrow.
The purple words in today’s Connections
The theme is ending in color homophones. The four answers are Cameroon (maroon), cockatiel (teal), unread (red) and whistleblew (blue).
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Technologies
Today’s Wordle Hints, Answer and Help for Nov. 30, #1625
Here are hints and the answer for today’s Wordle for Nov. 30, No. 1,625.
Looking for the most recent Wordle answer? Click here for today’s Wordle hints, as well as our daily answers and hints for The New York Times Mini Crossword, Connections, Connections: Sports Edition and Strands puzzles.
Today’s Wordle puzzle is a tough one. If you need a new starter word, check out our list of which letters show up the most in English words. If you need hints and the answer, read on.
Today’s Wordle hints
Before we show you today’s Wordle answer, we’ll give you some hints. If you don’t want a spoiler, look away now.
Wordle hint No. 1: Repeats
Today’s Wordle answer has one repeated letter.
Wordle hint No. 2: Vowels
Today’s Wordle answer has one vowel and one sometimes vowel.
Wordle hint No. 3: First letter
Today’s Wordle answer begins with M.
Wordle hint No. 4: Last letter
Today’s Wordle answer ends with Y.
Wordle hint No. 5: Meaning
Today’s Wordle answer can refer to weather that is unpleasantly warm and humid.
TODAY’S WORDLE ANSWER
Today’s Wordle answer is MUGGY.
Yesterday’s Wordle answer
Yesterday’s Wordle answer, Nov. 29, No. 1624 was GRUFF.
Recent Wordle answers
Nov. 25, No. 1620: PLEAD
Nov. 26, No. 1621: HOVEL
Nov. 27, No. 1622: REMIT
Nov. 28, No. 1623: COLIC
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Technologies
Anker’s Best MagSafe Car Charger Is Still $27 Off Before Cyber Monday Even Starts
Get wired-like charging speeds and MagSafe compatibility with Anker’s newest wireless car charging bundle, currently just $63.
Black Friday and Cyber Monday are some of the best shopping days of the year. You can find huge discounts on big ticket items like TVs and laptops. But it’s also a great time of year to snap up essential tech, like the kind designed to make life a little easier. This Anker MagSafe wireless car charging bundle is currently 30% off at Amazon, which means it’s down to just $63. That saves you $27 on a handy device you’ll use every day.
The Anker MagSafe wireless car charging gives your iPhone a fast and steady way to power up while you navigate. It delivers up to 25-watt wireless charging speeds and with onboard active cooling, your phone stays comfortable to the touch.
Hey, did you know? CNET Deals texts are free, easy and save you money.
What sets this charger apart is that its performance and cooling tech is built into a surprisingly compact package. The stand uses an ultra-strong Qi2 magnetic lock to keep your phone secure through bumps and turns. You can even tilt the mount and switch between portrait and landscape modes for navigation without blocking the view. The bundle has everything you need to get started including a 60-watt dual-USB-C charger, an adequately long USB-C cable, and cable organizers for a clean setup. Anker also includes a two-year warranty for peace of mind.
If you are getting your car prepped up for driving to a holiday vacation or just need a faster charging mount for your daily commute, this deal makes a lot of sense. CNET’s experts are also tracking more Black Friday and Cyber Monday picks across Apple products, headphones, and more, so you can score more savings before the sales season wraps up. We’ve also got a list of our favorite Anker products currently on sale.
Why this deal matters
A high-quality charger is a great addition to any car, allowing you to quickly top up your phone on the go. You will especially want to look out for options from a top-tier brand like Anker for its fast charging speeds and reliability. This Black Friday deal is an excellent opportunity to save big on a staple car accessory. With holiday shopping heating up and tech accessories being one of the most popular categories, we expect the deal to sell out quick. So don’t wait too long before jumping on it.
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