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CRISPR startup wants to resurrect the woolly mammoth by 2027

Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.

The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

Act Now to Get This Rare Cyber Monday Nintendo Switch 2 Deal Before It’s Gone

Pick up the Switch 2, Mario Kart World and a Samsung 256GB microSD Express card for $538.

Cyber Monday brings us many exciting offers, from shiny new laptops to record-low prices on televisions and headphones. But few offers are as enticing as a rare bundle deal on the Nintendo Switch 2, like the one we just spotted at Amazon. You get the Nintendo Switch 2, Mario Kart World game download and a Samsung 256GB microSD Express Card for one price of $538. That’s $22 off what might be the greatest gift you’ll ever give.

Considering the tumultuous past of this coveted gaming device, which involved delays and price increases due to tariffs, we didn’t think the Nintendo Switch 2 would go on sale at all this holiday season.

Our reviewer Scott Stein got his hands on a Switch 2 early on, and called it «the best handheld console.» He praised the notably better graphics over the original Switch, the big nearly 8-inch screen and the ergonomic design.

One of the cons he pointed out, though, was the lack of storage. Though the console has 256GB of internal memory, which is a significant upgrade over the previous model, you will quickly use up that storage as game files are bigger. Stein notes that the microSD Express cards could be hard to find, as the Switch 2 only take the Express cards, not the ones that worked with the previous Switch model. This bundle eliminates that issue, and the included Samsung 256GB microSD Express card will instantly double your storage.

You will also get a download of Mario Kart World included in the price. Amazon also has a bundle that includes the Nintendo Switch 2 and Mario Kart World for $499. This isn’t a significant savings, however it is in stock. The microSD Express card is not included. If you’re looking to pick one up separately, you can get one at Walmart right now for $39, a $20 savings.

Why this deal matters

To be honest, we didn’t expect to see any Black Friday or Cyber Week deals on the Switch 2. They are hard to come by and stock has been selling out fast. If you’ve been hoping to get your hands on one, this bundle offers modest savings but big perks and pretty much makes one of the best gifts out there — for yourself or someone you really, really like. And if you’re looking for more great gaming gifts, check out our Cyber Monday gaming deals.

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Cyber Monday Brings a Record-Low Price on the Apple Watch Ultra 3, but It Won’t Last

Apple’s newest and most powerful smartwatch is now $99 off at Amazon, but don’t count on this deal being around all day.

The Apple Watch Ultra 3 is one of Apple’s latest models, debuting just a couple of months ago. Apple discounts can be scarce, especially on new devices, but we’ve spotted a Cyber Monday deal on Amazon that brings the Apple Watch Ultra 3 down by $99. That means you’ll pay $700 today. That’s a record low price for one of the best smartwatches on the market.

Currently, black and natural titanium are the only ones reflecting the discount.These prices often fluctuate, so we suggest checking out soon to lock in your price, as Apple Watch Ultra 3 deals tend to come and go quickly. If you’re considering this as a gift, word to the wise: these are shipped through Amazon, but shipping times can vary depending on your location — so it may not arrive in time for Christmas.

All Apple Watch Ultra 3 models come with cellular modems inside, so you can connect them to your carrier, assuming it supports the Apple Watch’s eSIM. That’ll allow you to stay connected even when you don’t have your iPhone with you.

The Apple Watch Ultra 3 comes in a large 49mm size, so it’s easy to read. Despite that huge display, Apple Watch Ultra 3 owners can expect long-lasting battery life. In fact, the Apple Watch Ultra 3 can run for up to 42 hours in normal mode and a whopping 72 hours in low-power mode.

This being an Apple Watch, it comes with all the usual health and fitness monitoring features, as well as sleep tracking. It can monitor your heart rate, track your progress thanks to its precise dual-frequency GPS and do a whole lot more.

If the standard Apple Watch models can’t quite live up to your busy, active lifestyle, this is the model for you. Be sure to order your new smartwatch before this deal expires.

SMARTWATCH DEALS OF THE WEEK

Deals are selected by the CNET Group commerce team, and may be unrelated to this article.

Why this deal matters

The latest Apple Watch Ultra 3 is the best of its kind. It has a new display that’s designed to be easier to read and has an impressive battery life. It isn’t the cheapest smartwatch on the market, but if you want the best that Apple has to offer, now is the time to place your order — before this deal ends.

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Cyber Monday Is Hours Away, but I’ve Already Found 53 Incredible Apple Deals Available Now

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