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CRISPR startup wants to resurrect the woolly mammoth by 2027

Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.

The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

Adorn Your Wrist With a 45mm Pixel Watch 3 for Just $200 This Black Friday

Both Amazon and Walmart are selling Google’s Pixel Watch 3 for just $200, but for how long?

There are tons of reasons to pick up a new smartwatch, not the least of which is monitoring your health and tracking your fitness goals. If you’re in the Android world, there are plenty of options to choose from right now. The Pixel Watch 3 is a solid choice, and it was our favorite Android smartwatch until the new Pixel Watch 4 took its place in the lineup. But the Watch 3 still boasts some great features that can help you stay on top of your wellness goals into the new year as well. And both Amazon and Walmart are running Black Friday deals that make it significantly cheaper than the Pixel Watch 4. 

Both retailers are selling the bigger 45mm model with a solid $100 discount, so you can pick one up for just $200. That’s $100 less than the Pixel Watch 4’s Black Friday price. Again, this offer is available at both Walmart and Amazon, so take your pick as to where you place your order. Just do it soon because we don’t know how long these Black Friday deals will last.

The impressive watch was previously our top Android smartwatch because of its attractive design, large screen and speedy charging. It no longer requires a Fitbit Premium membership to access your readiness score, and it has plenty of great tools for runners. However, although the watch comes with Google Assistant, it doesn’t include Gemini, Google’s AI

Lisa Eadicicco, a former senior editor, said in her CNET review, «The Pixel Watch 3’s upgrades are enough to keep it as my top pick for a general-purpose Android smartwatch. If you’re anything like me and consider yourself a casual runner in need of a general-purpose Android watch that’s sleek and comfortable, the Pixel Watch 3 won’t disappoint.»

If this isn’t the Pixel Watch for you, take a look at our full roundup on the best Pixel Watch deals going on right now.

SMARTWATCH DEALS OF THE WEEK

Deals are selected by the CNET Group commerce team, and may be unrelated to this article.

Why this deal matters

Google Watches don’t go on sale often. These rare discounts on the Pixel Watch 3 are thanks to the release of the Pixel Watch 4 earlier this year. This deal drops the 45mm model to just $200 — a new all-time low, and a strong value for one of the most versatile Android smartwatches available. 

Don’t miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source.

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I Regularly Buy Belkin Gear at Full Price, but You Can Save Up to 63% for Black Friday

Belkin makes excellent mobile accessories, from cables to wireless charging stands. Snag some of our favorites for less this Black Friday.

You can never have too many charging options, especially when you can stock up during an epic sale. We’re just hours away from Black Friday, and Belkin is offering up to 65% off its mobile accessories at Amazon. Belkin regularly shows up in our best lists, including our roundup of top wireless chargers.

The brand makes excellent gear at reasonable prices, and those prices just got even lower. Whether you’re looking for a charging station for your nightstand or a sleek power bank for travel days, there’s a Belkin Black Friday deal for you.

The Belkin MagSafe three-in-one wireless charging stand landed on our list of best wireless chargers for its impressive fast-charging performance. Our expert, David Carnoy, praised the stand’s convenient design and its ability to fast charge Apple’s entire ecosystem. That means you’ll be able to charge your iPhone, Apple Watch and any AirPods with a wireless charging case — all at once. Carnoy’s only complaint was the price; however, it’s substantially discounted for Black Friday. Belkin’s MagSafe three-in-one wireless charging stand is now just $78 — 35% off the usual $120 price.

If you spend a lot of time in your car, be it a long commute or regular road trips, a good car mount is a must. The Belkin MagSafe car mount is another one of our favorite accessories. The magnets provide a strong, secure hold for your phone, and you can rotate it for easy access. The mount plus charger is currently available for $55, down from $80.

Speaking of road trips, if you’re traveling this holiday season, you definitely need a portable power bank. Belkin has a 10,000 mAh power bank with a built-in USB-C power delivery cable for $15. This 20-watt charger typically retails for $40, so you’re saving 63%. There are four colors, but this price only applies to the black model. Other colors are available for $30.

If you’ve got a Nintendo Switch 2 or you’re gifting it to a loved one, you’ll love Belkin’s Switch 2 travel case. It’s lightweight with a hard shell and has storage pockets for up to 12 game cards. Snag one right now for $22. Just make sure you click the on-page coupon to get the full discount.

Belkin also has huge discounts on headphones and earbuds if those are on your gift list this year.

Why this deal matters

Phone accessories, including chargers and earbuds, can wear quickly and are easy to lose. Third-party retailers like Belkin offer a solid selection of mobile accessories for all budgets. This Black Friday deal makes now an excellent time to shop with up to 63% off top-rated charging stations, car mounts and even headphones.

Impulse Buys Under $25 That Make Unexpectedly Great Gifts

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The Black Friday Gaming Deals You Want Are Already Here, Including PlayStation, Xbox and Alienware

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