Technologies

CRISPR startup wants to resurrect the woolly mammoth by 2027

Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.

You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.

The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.

«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»

It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.

Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.

Artificial wombs and other technology spinoffs

Church said he expects spinoffs from the company’s biotechnology and genetics work.

«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.

One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.

Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.

At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.

Jurassic Park-style tourism? Nope

Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.

But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.

Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.

Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.

One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.

Is species de-extinction a good idea?

There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.

Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.

But is that really the best use of our resources to help the planet? No, some researchers believe.

Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.

But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.

In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.

At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.

Technologies

Apple Reportedly Planning Cheaper Macs to Compete With Budget Chromebooks, PCs

Apple doesn’t market its machines as affordable, but that could be changing.

Apple may release more affordable Mac laptops to compete with Chromebooks and budget-friendly Windows laptops as early as 2026.

Bloomberg’s Mark Gurman reports the company has plans to roll out a machine for «well under $1,000.» According to Gurman, the new laptop is already in early production under the codename J700. This matches earlier rumors that a low-cost MacBook Air was in the pipeline at around $599, which would allow Apple to directly compete with other cheap laptops, including Chromebooks and Windows PCs.

A representative for Apple did not immediately respond to a request for comment.

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According to the report, costs will be kept down by using a lower-end LCD that’s smaller than the 13.6-inch MacBook Air, potentially making the new affordable MacBook as small as 12 inches.

Another way Apple could reduce the cost is by using an A-series iPhone chip, which falls short of the top-tier performance offered by the MacBook Pro or the current M4 Air. The upcoming chip may be a variant of the A19 Pro chip that debuted with the iPhone 17 Pro and iPhone Air, which Apple says is capable of MacBook-level performance.

As CNET senior editor Matt Elliott noted, the promise is a bold one. He speculates that the rumored $599 MacBook Air may get the same smartphone processor, or an M-series chip based on that architecture.

Bloomberg also reports that a MacBook Pro with an M5 Pro and M5 Max chip is in development, and Apple has completed work on a MacBook Air powered by the M5 chip, which is planned for release early next year.

The affordable laptop would be designed for casual users, students and businesses, specifically individuals who need a device for tasks such as web browsing, light media editing and document creation. The tech giant is also targeting the education market, as well as iPad buyers who may also want a traditional laptop.

«If this is strictly a move to entice consumers with a high-quality, lower-cost MacBook running MacOS in place of an iPad with a keyboard, then yes, Apple can likely take a chunk of that market,» said Josh Goldman, managing editor at CNET.

«Making inroads into the education market at this point, where Chromebooks have taken over since the pandemic, will prove challenging, though I’m sure it’s nothing that throwing billions of dollars at can’t fix,» CNET’s Goldman said.

This price range is ‘a big departure’

Price is likely to be key here. A $599 price tag would place the new Mac in the same range as more affordable Chromebooks and entry-level laptops, representing a significant change from Apple’s previous strategy.

«Apple potentially dipping into the Chromebook range of $300 to $500 with a new MacBook is a big departure,» said Goldman.

He notes that one of Apple’s most affordable MacBooks is the M4 MacBook Air, available new starting at $999 for the 13-inch model. Walmart still sells a new M1 MacBook Air, a 5-year-old laptop, for around $600.

By contrast, an iPad 11th Gen with a Magic Keyboard will run you around $600, making it clear that Apple’s target market for the rumored device is students and lighter users.

Apple typically hasn’t targeted the lower-priced segment of the market with its MacBooks. However, with consumer wallets under pressure from inflation, high tariffs and layoffs, an affordable MacBook could be imperative and timely.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Nov. 5, #408

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Nov. 5, No. 408.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition is pretty diverse. The blue answers stuck out to me right away, because some of them are super famous and the others felt like they belonged with those names. If you’re struggling but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by the Times. It doesn’t show up in the NYT Games app but appears in The Athletic’s own app. Or you can play it free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: How to see a game.

Green group hint: Soccer.

Blue group hint: Giddy up!

Purple group hint: Not a run play.

Answers for today’s Connections: Sports Edition groups

Yellow group: Ways to consume a sporting event.

Green group: NWSL teams.

Blue group: Triple Crown horse racing winners.

Purple group: Pass ____.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is ways to consume a sporting event. The four answers are in person, radio, streaming and television.

The green words in today’s Connections

The theme is NWSL teams. The four answers are Current, Dash, Pride and Spirit.

The blue words in today’s Connections

The theme is Triple Crown horse racing winners. The four answers are Citation, Gallant Fox, Omaha and Secretariat.

The purple words in today’s Connections

The theme is pass ____. The four answers are breakup, interference, protection and rush.

Technologies

Today’s NYT Connections Hints, Answers and Help for Nov. 5, #878

Here are some hints and the answers for the NYT Connections puzzle for Nov. 5, #878.

Looking for the most recent Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles.

Today’s NYT Connections puzzle has a diverse mix of topics, including a neat blue category that music fans will ace. And it isn’t too tough, but if you need help, you’re in the right place. Read on for clues and today’s Connections answers.

The Times now has a Connections Bot, like the one for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. Players who are registered with the Times Games section can now nerd out by following their progress, including the number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak.

Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time

Hints for today’s Connections groups

Here are four hints for the groupings in today’s Connections puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Mess up.

Green group hint: Lead pipe is another one.

Blue group hint: They command the stage.

Purple group hint: Not snow, but …