Technologies
CRISPR startup wants to resurrect the woolly mammoth by 2027
Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.
You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.
The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.
«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»
It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.
Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.
Artificial wombs and other technology spinoffs
Church said he expects spinoffs from the company’s biotechnology and genetics work.
«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.
One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.
Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.
At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.
Jurassic Park-style tourism? Nope
Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.
But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.
Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.
Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.
One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.
Is species de-extinction a good idea?
There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.
Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.
But is that really the best use of our resources to help the planet? No, some researchers believe.
Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.
But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.
In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.
At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.
Technologies
Your Next Vacation Starts in a Chat: TripAdvisor Debuts App Inside ChatGPT
You can tap AI and TripAdvisor for your travel planning.
You may already use artificial intelligence for planning vacations, but now you can use a new TripAdvisor app inside of ChatGPT to book hotels. The app puts TripAdvisor’s reviews and hotel insights directly into ChatGPT. It’s «a new AI-powered way to experience the best of TripAdvisor,» according to the travel company.
(Disclosure: Ziff Davis, CNET’s parent company, in April filed a lawsuit against OpenAI, alleging it infringed Ziff Davis copyrights in training and operating its AI systems.)
Using the app, trip planners can see top-rated TripAdvisor hotels on an interactive map. They can also read TripAdvisor review summaries, access details about hotels, including images and amenities, and refine results with conversational follow-ups.
Once a would-be traveler selects a hotel, they’ll see available deals from booking sites. When they choose one, they will be redirected to TripAdvisor or one of its partners to complete the booking.
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The new app is available to logged-in ChatGPT users in the US on Free, Go, Plus and Pro plans. You can start using it by opening ChatGPT, navigating to Settings, then Apps & Connectors, and Browse Apps and connect to TripAdvisor. (You should only have to follow these steps once.) Then, and on subsequent visits, simply start your message in ChatGPT with the word TripAdvisor.
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Technologies
Group Chats With ChatGPT Are Rolling Out Globally
OpenAI wants you to collaborate with its chatbot in a group setting.
Last week, OpenAI — always looking for opportunities to put its chatbot into new spaces — introduced Group Chats with ChatGPT baked right in. Based on early feedback, it’s now expanding the feature to all logged-in users on ChatGPT Free, Go, Plus and Pro plans globally over the coming days.
The feature is pitched as a new way to use ChatGPT with other people, especially in collaboration efforts, like planning a big event.
Up to 20 people can be added to a group chat, and messages between individuals don’t count against the rate limit to ChatGPT — only when it responds.
(Disclosure: Ziff Davis, CNET’s parent company, in April filed a lawsuit against OpenAI, alleging it infringed Ziff Davis copyrights in training and operating its AI systems.)
Group chats use ChatGPT-5.1 Auto. OpenAI has also introduced some new implementations of how and when the chatbot responds. It’s been taught new social behaviors for group chats and will apparently follow the flow of the conversation and stay quiet or chime in based on what’s being said.
Adding «ChatGPT» to a message you send will always yield a response from the AI chatbot. You can also provide custom instructions to ChatGPT for the entire chat if you want it to reply in a certain tone or personality, and it can react to messages with emoji.
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Group Chats don’t use memory from your existing personal chats, and new memory isn’t created from group conversations, though OpenAI says it’s exploring a way for you to opt in to use existing memory in the future.
If you’re concerned that you’ll be thrown into a dozen chats without your permission, then you’ll likely be happy to hear that you must accept an invitation before you can be added to a group chat with ChatGPT. Additional safeguards are also in place for users under the age of 18, which will reduce sensitive content to all within the group chat.
OpenAI says Group Chats are the beginning of its effort to make ChatGPT more of a shared and collaborative space for people.
Technologies
Today’s NYT Connections: Sports Edition Hints and Answers for Nov. 21, #424
Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Nov. 21, No. 424.
Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.
Today’s Connections: Sports Edition is a fun one. If you know a Gen Z person, you might be familiar with their favorite nonsense phrase, «6-7.» The puzzle editors throw a 6 and a 7 into the puzzle today just to see if we’re paying attention. Do the numbers end up in the same group? I bet you know the answer to that one. If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.
Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.
Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta
Hints for today’s Connections: Sports Edition groups
Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.
Yellow group hint: Splish-splash.
Green group hint: Football score.
Blue group hint: Colorado QB.
Purple group hint: Not small.
Answers for today’s Connections: Sports Edition groups
Yellow group: Four primary swimming strokes.
Green group: Touchdown.
Blue group: Associated with John Elway.
Purple group: Big ____.
Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words
What are today’s Connections: Sports Edition answers?
The yellow words in today’s Connections
The theme is four primary swimming strokes. The four answers are back, breast, fly and free.
The green words in today’s Connections
The theme is touchdown. The four answers are 6, paydirt, TD and tuddy.
The blue words in today’s Connections
The theme is associated with John Elway. The four answers are 7, Broncos, No. 1 pick and Stanford.
The purple words in today’s Connections
The theme is Big ____. The four answers are 12, dance, leagues and ten.
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