Technologies
CRISPR startup wants to resurrect the woolly mammoth by 2027
Colossal has landed $15m in funding to restore the woolly mammoth to the Arctic — and it thinks it can birth calves in four to six years.
You’ve heard of startups building computer chips, delivery drones and social networks. One called Colossal has a very different goal: bringing the woolly mammoth back from extinction by 2027 using CRISPR, a revolutionary gene editing technology.
The plan isn’t to re-create true woolly mammoths exactly but rather to bring their cold-adapted genetic traits like small ears and more body fat to their elephant cousins, creating a hybrid that can wander the tundra where mammoths haven’t been seen for 10,000 years. Colossal’s co-founders are Chief Executive Ben Lamm, who started five companies before this, and George Church, a Harvard Medical School professor with deep CRISPR expertise.
«Our true North Star is a successful restoration of the woolly mammoth, but also its successful rewilding into interbreeding herds in the Arctic,» Lamm said. «We’re now focusing on having our first calves in the next four to six years.»
It’s an interesting illustration of an imperative sweeping the tech world: Don’t just make money, help the planet too. Tesla’s mission is to electrify transport to get rid of fossil fuels that hurt Earth. Bolt Threads wants to replace leather with a fungal fiber-based equivalent that’s easier on the environment than animal agriculture. Colossal hopes its work will draw attention to biodiversity problems and ultimately help fix them.
Colossal has raised $15 million so far, led by investment firm Tulco. The startup’s 19 employees work at its Dallas headquarters and in offices in Boston and Austin, Texas, and it’s using its funds to hire more.
Artificial wombs and other technology spinoffs
Church said he expects spinoffs from the company’s biotechnology and genetics work.
«The pipeline of large scale genome engineering techniques can be applied to many other applications beyond de-extinction, and therefore [are] most promising for commercialization,» he said.
One technology ripe for commercialization is multiplex genome engineering, a technique Church helped develop that speeds genetic editing by making multiple changes to DNA at once.
Colossal also hopes to develop artificial wombs to grow its mammoth embryos. Just growing 10 woolly mammoths with surrogate elephant mothers isn’t enough to get to the large-scale herds the company envisions.
At the foundation of Colossal’s work is CRISPR. This technology, adapted from a method bacteria evolved to identify attacking viruses and chop up their DNA, is now a mainstay of genetic engineering, and Church has been involved since CRISPR’s earliest days.
Jurassic Park-style tourism? Nope
Selling or licensing spinoff technology is a somewhat indirect way of running a business. A more direct option is selling tickets to tourists. After all, humans already pay lots of money to see charismatic megafauna like lions, elephants and giraffes on African safaris. Seeing a creature that’s been gone for 10,000 years could add to the excitement.
But that’s not Colossal’s game plan. «Our focus is on species preservation and protection of biodiversity right now, not in putting them in zoos,» Lamm said. By re-creating woolly mammoths, Colossal can preserve the genetic legacy of Asian elephants that now are endangered.
Another candidate species Colossal wants to re-create is the woolly rhinoceros, a relative to the critically endangered Sumatran rhino.
Although Colossal doesn’t plan to build a tourist destination, it does have a woolly mammoth rewilding site in mind that sounds awfully close to Jurassic Park: Pleistocene Park. This area of about 60 square miles in northern Russia, named after the geologic period that ended with the last ice age, is where researchers Sergey and Nikita Zimov are trying to test their theories about the ecological and climatic effects of rewilding.
One Zimov idea is that woolly mammoths will trample snow and knock down trees. That, in turn, will restore grasslands that reflect more of the sun’s warming rays and eliminate insulating snow and forests so the ground cools more. And that means the ground will stay frozen instead of releasing its current store of carbon dioxide and methane greenhouse gases. About 260 billion to 300 billion metric tons of carbon could be released from thawing permafrost by 2300, scientists calculate, exacerbating the weather extremes and other problems caused by climate change.
Is species de-extinction a good idea?
There’s an appeal to the idea of de-extinction. Humans have dramatically altered the planet, and the United Nations estimates we threaten 1 million species with extinction as a result.
Colossal hopes its work will raise more attention to the biodiversity collapse. And it also plans to create detailed genetic descriptions of many endangered species «so we have the recipe if that species does go extinct,» Lamm said.
But is that really the best use of our resources to help the planet? No, some researchers believe.
Resurrecting species could have some benefits, but money would be better spent on trying to protect ones that are still around, a group of biologists argued in one paper published in Nature Ecology & Evolution. «Potential sacrifices in conservation of extant species should be a crucial consideration in deciding whether to invest in de-extinction or focus our efforts on extant species,» the researchers wrote.
But this isn’t government money Colossal is talking about, and Lamm argues that his startup’s work complements other conservation efforts. And, he argues, startups can move faster than government-funded work.
In a world dominated by climate crisis headlines, a startup that makes money with an ecosystem-improvement focus has special appeal. One investor, Zack Lynch of Jazz Venture Partners, is excited by software, hardware and biotech he expects Colossal will create.
At the same time, «these breakthroughs will help address issues such as land degradation, animal pollinator loss and other negative biodiversity trends,» Lynch said. Given how big our environmental problems are, you can see why an investor might be interested.
Technologies
Today’s NYT Mini Crossword Answers for Monday, Dec. 1
Here are the answers for The New York Times Mini Crossword for Dec. 1.
Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.
Need some help with today’s Mini Crossword? Read on for the answers. And if you could use some hints and guidance for daily solving, check out our Mini Crossword tips.
If you’re looking for today’s Wordle, Connections, Connections: Sports Edition and Strands answers, you can visit CNET’s NYT puzzle hints page.
Read more: Tips and Tricks for Solving The New York Times Mini Crossword
Let’s get to those Mini Crossword clues and answers.
Mini across clues and answers
1A clue: Tree that’s a symbol of Canada
Answer: MAPLE
6A clue: Back street
Answer: ALLEY
7A clue: Kind of steak with a letter in its name
Answer: TBONE
8A clue: Beer pong targets
Answer: CUPS
9A clue: «___ Pinafore» (Gilbert and Sullivan opera)
Answer: HMS
Mini down clues and answers
1D clue: Show mutual interest, as on a dating app
Answer: MATCH
2D clue: «Bad» or «Good Kid, M.A.A.D City»
Answer: ALBUM
3D clue: Sits (down) heavily
Answer: PLOPS
4D clue: Contact ___
Answer: LENS
5D clue: Look here!
Answer: EYE
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Technologies
Today’s NYT Connections: Sports Edition Hints and Answers for Dec. 1, #434
Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Dec. 1, No. 434.
Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.
Today’s Connections: Sports Edition features one of those classic — and difficult — purple categories. You’ll need to look for words inside of words to get that grouping. (Or just solve the other three, and get purple by default.) If you’re struggling with today’s puzzle but still want to solve it, read on for hints and the answers.
Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t appear in the NYT Games app, but it does in The Athletic’s own app. Or you can play it for free online.
Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta
Hints for today’s Connections: Sports Edition groups
Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.
Yellow group hint: Maybe on the beach.
Green group hint: Deal me in.
Blue group hint: Not necessarily Jim.
Purple group hint: Look at the final part of the words.
Answers for today’s Connections: Sports Edition groups
Yellow group: Volleyball terms.
Green group: Poker terms.
Blue group: Jameses.
Purple group: Ends in an NWSL team.
Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words
What are today’s Connections: Sports Edition answers?
The yellow words in today’s Connections
The theme is volleyball terms. The four answers are dig, serve, set and spike.
The green words in today’s Connections
The theme is poker terms. The four answers are blind, flop, river and turn.
The blue words in today’s Connections
The theme is Jameses.The four answers are Cook, Harden, Shields and Worthy.
The purple words in today’s Connections
The theme is ends in an NWSL team.The four answers are balderdash (Houston Dash), concurrent (Kansas City Current), foreign (Seattle Reign) and microwave (San Diego Wave).
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Technologies
Today’s Wordle Hints, Answer and Help for Dec. 1, #1626
Here are hints and the answer for today’s Wordle for Dec. 1, No. 1,626.
Looking for the most recent Wordle answer? Click here for today’s Wordle hints, as well as our daily answers and hints for The New York Times Mini Crossword, Connections, Connections: Sports Edition and Strands puzzles.
Today’s Wordle puzzle is a little tricky. Many people will confuse it with a similar word that’s spelled differently. If you need a new starter word, check out our list of which letters show up the most in English words. If you need hints and the answer, read on.
Today’s Wordle hints
Before we show you today’s Wordle answer, we’ll give you some hints. If you don’t want a spoiler, look away now.
Wordle hint No. 1: Repeats
Today’s Wordle answer has no repeated letters.
Wordle hint No. 2: Vowels
Today’s Wordle answer has two vowels.
Wordle hint No. 3: First letter
Today’s Wordle answer begins with L.
Wordle hint No. 4: Last letter
Today’s Wordle answer ends with H.
Wordle hint No. 5: Meaning
Today’s Wordle answer can refer to causing a liquid to drain away from something such as soil or ash.
TODAY’S WORDLE ANSWER
Today’s Wordle answer is LEACH.
Yesterday’s Wordle answer
Yesterday’s Wordle answer, Nov. 30, No. 1625 was MUGGY.
Recent Wordle answers
Nov. 26, No. 1621: HOVEL
Nov. 27, No. 1622: REMIT
Nov. 28, No. 1623: COLIC
Nov. 29, No, 1624: GRUFF
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