Technologies

COVID delta variant fears spur booster shot plans around the world. The latest update

The WHO calls for a pause in the world’s booster plans, while San Francisco gives Johnson & Johnson recipients the green light for an mRNA dose. Here’s what’s going on with boosters.

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

Calling the eradication of the COVID-19 virus «unlikely,» a UK scientific advisory group says (PDF) there is a «realistic possibility» that a variant will emerge that is resistant to the current battery of vaccines. Governments, public health organizations and vaccine makers are all tracking developments in coronavirus variants like delta and lambda, hoping to answer the question if booster shotstargeting new variants will be needed soon.

«Things are going to get worse,» Dr. Anthony Fauci, the chief medical advisor to the president, said Sunday on ABC’s This Week.

Currently in the US, «breakthrough» coronavirus cases caused by the dominant delta variant amount to less than 1% of people who are fully vaccinated. Both Moderna and Pfizer vaccines are proven to be over 90% effective against hospitalizations and death. The surge in new COVID-19 cases are primarily affecting unvaccinated people and causing community spread, and in turn, the return of mask mandates and guidance in hard-hit areas, even for people who have full vaccine protection. The debate over mask use and vaccine boosters underscores how scientists and other health experts continue to grapple with the uncertainties of COVID-19.

The Centers for Disease Control and Prevention’s recent study shows that vaccinated people can both contract the highly contagious delta variant and spread it. According to a widely reported internal CDC memo, the delta variant spreads as easily as chicken pox, which is considered more contagious than the flu and less contagious than measles.

To prepare for the possibility of a booster shot, the CDC said it’s weighing a third vaccine dose for people with compromised immune systems. Over the weekend, Israel began administering third doses of the vaccine to those 60 and older, and the UK plans to do the same. However, this is resulting in a backlash among countries that are struggling to deliver first and second shots to residents.

On Wednesday, World Health Organization Director-General Tedros Adhanom Ghebreyesus called for a «moratorium» on booster shots in high-income countries, citing the global disparity in vaccine distribution. Of the 4 billion doses administered globally, 80% have gone to high- and upper-middle income countries that make up less than half of the world’s population, he said.

«We cannot accept countries that have already used most of the global supply of vaccines using even more of it, while the world’s most vulnerable people remain unprotected,» Tedros said.

What does all of this mean in the US? Here’s what we know about COVID booster shots now.

Booster shot vs. new COVID vaccine: There’s a difference

Along with Moderna, Pfizer’s current two-dose vaccine provides powerful and effective protection against all known variants of COVID-19, including the delta variant, according to ongoing studies and self-reported statistics. But Pfizer also announced in July that a third dose of its vaccine is currently under development. The company said its own research showed a booster shot of its current vaccine increased antibody levels five to 10 times higher over its two-dose shots, noting that its results have not been published or peer-reviewed.

Pfizer said it believes the level of protection the first two doses of its vaccine provide can gradually decrease over time, and a third booster dose may be needed «within six to 12 months» after a person is fully vaccinated with the first two doses. Pfizer said a booster shot could enhance protection against the delta variant, which has been known to infect fully vaccinated people. Clinical trials on the booster are set to begin, as Pfizer seeks approval from government regulators for a third dose.

However, while a booster shot would complement the two doses of its existing vaccine, Pfizer is also separately working on a new vaccine formulation targeting the delta variant.

What do the CDC, FDA and WHO think about a booster shot?

The CDC and FDA initially exercised caution over a booster shot.

«People who are fully vaccinated are protected from severe disease and death, including from the variants currently circulating in the country such as delta,» the CDC and FDA said in a July 8 joint statement, without naming Pfizer. The government agencies emphasized the need for all eligible people to receive full doses of one of the approved vaccines, all of which are free.

The CDC and FDA said the question of a booster requires extensive scientific data and doesn’t depend on the input from pharmaceutical companies alone. «Virtually all COVID-19 hospitalizations and deaths are among those who are unvaccinated,» the statement mentioned, adding that the agencies will approve booster doses «if and when the science demonstrates that they are needed.»

New research has demonstrated a need. There is a growing consensus among Biden administration health officials that older individuals and those with compromised immune systems may, in fact, need a third shot. At a White House press briefing Thursday, Fauci said that it is «extremely important for us to move» to get immunocompromised people a booster, citing observational data that they generally aren’t «adequately protected» with the standard vaccine dose.

«We are now working on that, and we’ll make that be implemented as quickly as possible,» Fauci said. About 2.7% of the US adult population is immunosuppressed, CNBC reported, but immunocompromised people make up about 44% of people hospitalized with COVID complications.

Earlier in the week, at a WHO press briefing Wednesday, Tedros said that while he understands «the concern of all governments to protect their people from the delta variant,» booster shots shouldn’t be prioritized until the world’s most vulnerable people and health care workers are vaccinated.

«We call on vaccine producers to prioritize Covax,» Tedros said, referring to the world’s COVID-19 vaccine distribution program.

Is Moderna also planning to develop a booster shot?

While scientists and public health officials continue to study if those who are fully vaccinated will need a booster shot, Moderna said — along with Pfizer — it is exploring a third vaccine dose to complement the initial two vaccine shots.

I got Johnson & Johnson — Do I need a booster?

No, fully vaccinated Americans don’t need a booster yet, including those who got the single dose of Johnson & Johnson’s COVID vaccine, according to the country’s health officials. But residents in San Francisco who received Johnson & Johnson’s one-dose COVID vaccine were given the green light Tuesday to get a dose of an mRNA vaccine, though it still isn’t recommended by the city’s health department.

Dr. Grant Colfax, San Francisco’s health director, said that there isn’t conclusive evidence that getting a dose of Pfizer or Moderna benefits those who got the J&J shot, but there’s also not evidence to show it’s harmful, the San Francisco Chronicle reported.

«If people received the Johnson & Johnson and are requesting a second shot, we will accommodate them, but our policy has not changed,» Colfax said.

San Francisco’s decision to legitimize Johnson & Johnson vaccine recipients getting an mRNA vaccine comes in light of a small study that suggests the vaccine isn’t nearly as effective against the delta variant as the other vaccines. (Another study suggests that Johnson & Johnson remains effective, and the drug-maker continues to claim the vaccine is effective.)

Would the booster shot be free?

The current one-dose vaccine shot from Johnson & Johnson and two-dose versions from Moderna and Pfizer are free to anyone who wants to get vaccinated. According to the Biden administration, COVID-19 booster shots will also be free, if and when they’re approved.

Is it a good idea to mix and match COVID vaccines?

The CDC doesn’t recommend mixing and matching vaccines from the different makers, saying it hasn’t evaluated the effectiveness of mixing vaccine doses and that the «vaccines are not interchangeable.»

However, other global health agencies and countries are testing administered vaccines from two different manufacturers. In the UK, for example, a recent study found that those who received a first dose of the AstraZeneca vaccine and a second of Pfizer had a higher immune response than those who received two doses of the AstraZeneca vaccine.

In early June, the National Institutes of Health started a trial that tests mixing COVID-19 vaccines, and will determine if those who got Pfizer or J&J initially can safely receive a Moderna booster. The initial results of the study are expected in late summer 2021, the NIH said in a news release.

While we wait to see how the situation develops, here’s what we know about the delta variant, more about COVID-19 boosters and if you need to continue to wear a mask.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

Anthropic Launched New Claude 4 Gen AI Models. Here’s What They Do

The models can now use tools like web searches during extended reasoning tasks.

The latest versions of Anthropic’s Claude generative AI models made their debut Thursday, including a heavier-duty model built specifically for coding and complex tasks.

Anthropic launched the new Claude 4 Opus and Claude 4 Sonnet models during its Code with Claude developer conference, and executives said the new tools mark a significant step forward in terms of reasoning and deep thinking skills.

The company launched the prior model, Claude 3.7 Sonnet, in February. Since then, competing AI developers have also upped their game. OpenAI released GPT-4.1 in April, with an emphasis on an expanded context window, along with the new o3 reasoning model family. Google followed in early May with an updated version of Gemini 2.5 Pro that it said is better at coding.

Claude 4 Opus is a larger, more resource-intensive model built to handle particularly difficult challenges. Anthropic CEO Dario Amodei said test users have seen it quickly handle tasks that might have taken a person several hours to complete.

«In many ways, as we’re often finding with large models, the benchmarks don’t fully do justice to it,» he said during the keynote event.

Claude 4 Sonnet is a leaner model, with improvements built on Anthropic’s Claude 3.7 Sonnet model. The 3.7 model often had problems with overeagerness and sometimes did more than the person asked it to do, Amodei said. While it’s a less resource-intensive model, it still performs well, he said.

«It actually does just as well as Opus on some of the coding benchmarks, but I think it’s leaner and more narrowly focused,» Amodei said.

Anthropic said the models have a new capability, still being beta tested, in which they can use tools like web searches while engaged in extended reasoning. The models can alternate between reasoning and using tools to get better responses to complex queries.

The models both offer near-instant response modes and extended thinking modes.

All of the paid plans offer both Opus and Sonnet models, while the free plan just has the Sonnet model.

Technologies

Today’s NYT Strands Hints, Answers and Help for May 23, #446

Here are hints and answers for the NYT Strands puzzle No. 446 for May 23.

Looking for the most recent Strands answer? Click here for our daily Strands hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections and Connections: Sports Edition puzzles.

Today’s NYT Strands puzzle has a humorous title, and if you understand the reference, you’ll know what words to look for. If you need hints and answers, read on.

I go into depth about the rules for Strands in this story.

If you’re looking for today’s Wordle, Connections and Mini Crossword answers, you can visit CNET’s NYT puzzle hints page.

Read more: NYT Connections Turns 1: These Are the 5 Toughest Puzzles So Far

Hint for today’s Strands puzzle

Today’s Strands theme is: The musical fruit

If that doesn’t help you, here’s a clue: There are magical ones in fairy tales.

Clue words to unlock in-game hints

Your goal is to find hidden words that fit the puzzle’s theme. If you’re stuck, find any words you can. Every time you find three words of four letters or more, Strands will reveal one of the theme words. These are the words I used to get those hints, but any words of four or more letters that you find will work:

REEK, GADS, PLAY, PLAYS, PITA, DIAL, FALL, PALL, PALLS, FALLS, GENIE, BEEN, LACK, DENY, NILL.

Answers for today’s Strands puzzle

These are the answers that tie into the theme. The goal of the puzzle is to find them all, including the spangram, a theme word that reaches from one side of the puzzle to the other. When you’ve got all of them (I originally thought there were always eight but learned that the number can vary), every letter on the board will be used. Here are the nonspangram answers:

FAVA, NAVY, BLACK, GREEN, PINTO, KIDNEY, CANNELLINI

Today’s Strands spangram

Today’s Strands spangram is BEANSALAD. To find it, start with the B that’s three letters to the right on the top row, and wind down.

Technologies

The Marvel Rivals Auto Battler Is a Natural Evolution of Hero Shooters

Move over Teamfight Tactics. Marvel Rivals’ new limited-time mode is the perfect addition to the auto battler genre.

Marvel Rivals has been a breath of fresh air for the hero shooter genre, combining popular comic book characters and chaotic third-person shooter action to create epic team fights that keep me coming back for more.

Fast-paced combat is the name of the game in Marvel Rivals, which is why it could come across as a confusing development that the next limited-time mode launching in Marvel Rivals Season 2.5 is a form of auto battler (also frequently referred to as auto chess).

Ultron’s Battle Matrix Protocol is an experimental mode launching on June 6, where six players will draft teams of heroes to go head to head with their opponents’ drafts. You’ll be able to support your AI teams while the new hero Ultron (also debuting in season 2.5) is chipping in extra healing and damage to the fight.

Aside from the fact that it’ll be cool to stage your own version of Marvel Comics’ Secret Wars, is the decision to add an auto battler to Marvel Rivals (which has previously released limited-time modes that mostly tracked with the shooter’s core gameplay loop) really all that far out of left field? I don’t think so.

Why is Marvel Rivals getting an auto battler mode?

The new mode is similar to multiplayer online battle arena spinoffs such as Dota Auto Chess and League of Legends’ Teamfight Tactics. I think drawing the line from a multiplayer online battle arena (MOBA) to auto battler is easy for most people.

MOBAs are strategy games first and foremost, where players pick and choose items to craft builds that will help them win their lane, while also contributing to big team fights. Players need to work together to overwhelm the other team and push them back to their spawn.

MOBAs and auto battlers are both about team synergy, positioning and picking the right upgrades, so it’s not surprising to people when characters from a game in one of these genres appear in another.

There are many people that wouldn’t associate hero shooters with MOBAs in the slightest. Games like Marvel Rivals have a high ceiling for very different mechanical skills — especially aiming. But hero shooters are also complex strategy games that share many of the same fundamentals as a MOBA.

Putting together a viable team composition with strong character is the most important part of a hero shooter — and Marvel Rivals takes this to another level with the strongest team-up abilities that require multiple heroes to activate.

An auto battler will allow people to experiment team compositions that don’t often get played in real Marvel Rivals’ matches, and could even help the community find new experimental hero combinations that have the potential to shake up common ways people play the game.

In Ultron’s Battle Matrix Protocol, as the auto battler mode is called, players will be able to put together balanced teams, lock in the risky GATOR strategy (which is nightmarishly similar to Overwatch’s GOATS meta) or fall back on triple support with brand new upgrades that change how the game works.

Absurd power scaling might look like Overwatch 2’s Stadium mode

There’s a clear rivalry between Overwatch 2 and Marvel Rivals, since they’re the two biggest hero shooters on the market right now. Blizzard’s hero shooter is entering its ninth year of life with flagging interest, but its solid fundamentals have been a high bar for Marvel Rivals to hurdle.

Both games have been trying out bold new things — Overwatch 2 recently shipped the MOBA-like Stadium mode that lets players augment popular abilities and take powerful passives as they fight in a flurry of different objectives in a best of seven gauntlet.

Ultron’s Battle Matrix Protocol in some ways feels like NetEase’s response to Blizzard’s big success with Stadium mode. You might not have quite as much influence on the outcome of each battle, but this serves as a proof of concept for Marvel Rivals’ hero power scaling.

This new mode also lets players pick passive abilities that buff certain roles as well as more powerful hero-specific upgrades that drastically alter the course of a fight, so the snowballing power of a Stadium match is very much emulated here.

In the Season 2.5 developer vision video, we got a look at what some of the upgrades will look like.

Venom can grow into a hulking monster after devouring enemies with his ultimate ability, Hela cuts a swath through the playing field with a field of flying daggers, Psylocke zips around her ultimate ability’s area of effect at twice her normal speed and Namor summons many more squid turrets to attack his enemies.

It’s safe to assume that every character in the game will have some kind of special power unlocked in the later rounds of an Ultron’s Battle Matrix Protocol match. This definitely isn’t NetEase reheating Blizzard’s nachos, but I do think it’s indicative of a broader shift toward making hero shooters feel a little bit more chaotic and unrestrained.

Game balance is important, but one of the biggest draws of this genre is that each character is a unique power fantasy you can’t find elsewhere. I can’t imagine such in-depth upgrades were designed for a one-and-done mode, so it’ll be interesting to see where they might show up next.