Technologies

Surgeons transplant pig heart into human for first time

A medical milestone involving an animal’s genetically modified organ shines a hopeful light for the long ledger of patients awaiting organ transplants.

An ambitious crew of doctors transplanted a genetically modified pig’s heart into a human patient for the first time last week, marking a historic moment for medicine. As of Monday, three days after the surgery, the 57-year-old organ recipient, David Bennett, was reportedly still doing well.

While the team will monitor Bennett closely in coming weeks to ensure long-term benefits from the procedure, their medical milestone undoubtedly lays the groundwork for a new generation of animal-to-human organ transplants, known as xenotransplantation, and directly addresses the organ shortage crisis.

«There are simply not enough donor human hearts available to meet the long list of potential recipients,» Bartley P. Griffith, the University of Maryland School of Medicine physician who surgically transplanted the pig heart, said in a statement. He’s also a professor in transplant surgery at the medical school.

«We are proceeding cautiously,» Griffith added, «but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future.» According to organdonor.gov, well over 100,000 Americans are awaiting an organ transplant and more than 17 patients die each day before making their way to the top of the waitlist.

Leading up to his surgery, Bennett’s story unfortunately mimicked those of the many, many patients awaiting transplants. He was hospitalized and bedridden due to terminal heart disease.

«It was either die, or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,» Bennett said a day before the surgery was conducted, according to a statement provided by the University of Maryland School of Medicine. Several leading transplant centers had previously deemed Bennett ineligible for a conventional heart transplant, including UMSOM, where the groundbreaking surgery was performed.

«I look forward to getting out of bed after I recover,» Bennett said.

To conduct the life-saving operation as a last resort, doctors genetically modified a pig’s heart to increase the chances of Bennett’s body accepting it as its own circulatory control center. Without such modifications, non-human-to-human organ transplants carry risks like triggering severe, and sometimes fatal, immune responses.

Further guarding against the likelihood of a bodily rejection, physicians behind the surgery’s blueprint also administered certain drugs that suppress the immune system, which the UMSOM report says helped Bennett’s body accommodate the foreign organ.

«This is the culmination of years of highly complicated research to hone this technique in animals, with survival times that have reached beyond nine months,» Muhammad M. Mohiuddin, a professor of surgery at the University of Maryland School of Medicinewho established the cardiac xenotransplantation program with Griffith, said in a statement. «The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options.»

Technologies

Today’s NYT Strands Hints, Answers and Help for Oct. 23 #599

Here are hints and answers for the NYT Strands puzzle for Oct. 23, No. 599.

Looking for the most recent Strands answer? Click here for our daily Strands hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections and Connections: Sports Edition puzzles.

Today’s NYT Strands puzzle might be Halloween-themed, as the answers are all rather dangerous. Some of them are a bit tough to unscramble, so if you need hints and answers, read on.

I go into depth about the rules for Strands in this story.

If you’re looking for today’s Wordle, Connections and Mini Crossword answers, you can visit CNET’s NYT puzzle hints page.

Read more: NYT Connections Turns 1: These Are the 5 Toughest Puzzles So Far

Hint for today’s Strands puzzle

Today’s Strands theme is: Please don’t eat me!

If that doesn’t help you, here’s a clue: Remember Mr. Yuk?

Clue words to unlock in-game hints

Your goal is to find hidden words that fit the puzzle’s theme. If you’re stuck, find any words you can. Every time you find three words of four letters or more, Strands will reveal one of the theme words. These are the words I used to get those hints but any words of four or more letters that you find will work:

POND, NOON, NODE, BALE, SOCK, LOVE, LOCK, MOCK, LEER, REEL, GLOVE, DAIS, LEAN, LEAD, REEL

Answers for today’s Strands puzzle

These are the answers that tie into the theme. The goal of the puzzle is to find them all, including the spangram, a theme word that reaches from one side of the puzzle to the other. When you have all of them (I originally thought there were always eight but learned that the number can vary), every letter on the board will be used. Here are the nonspangram answers:

AZALEA, HEMLOCK, FOXGLOVE, OLEANDER, BELLADONNA

Today’s Strands spangram

Today’s Strands spangram is POISONOUS. To find it, look for the P that is the first letter on the far left of the top row, and wind down and across.

Technologies

Today’s NYT Connections: Sports Edition Hints and Answers for Oct. 23, #395

Here are hints and the answers for the NYT Connections: Sports Edition puzzle for Oct. 23, No. 395.

Looking for the most recent regular Connections answers? Click here for today’s Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles.

Today’s Connections: Sports Edition has one of those crazy purple categories, where you wonder if anyone saw the connection, or if people just put that grouping together because only those four words were left. If you’re struggling but still want to solve it, read on for hints and the answers.

Connections: Sports Edition is published by The Athletic, the subscription-based sports journalism site owned by The Times. It doesn’t show up in the NYT Games app but appears in The Athletic’s own app. Or you can play it for free online.

Read more: NYT Connections: Sports Edition Puzzle Comes Out of Beta

Hints for today’s Connections: Sports Edition groups

Here are four hints for the groupings in today’s Connections: Sports Edition puzzle, ranked from the easiest yellow group to the tough (and sometimes bizarre) purple group.

Yellow group hint: Fan noise.

Green group hint: Strategies for hoops.

Blue group hint: Minor league.

Purple group hint: Look for a connection to hoops.

Answers for today’s Connections: Sports Edition groups

Yellow group: Sounds from the crowd.

Green group: Basketball offenses.

Blue group: Triple-A baseball teams.

Purple group: Ends with a basketball stat.

Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words

What are today’s Connections: Sports Edition answers?

The yellow words in today’s Connections

The theme is sounds from the crowd. The four answers are boo, cheer, clap and whistle.

The green words in today’s Connections

The theme is basketball offenses. The four answers are motion, pick and roll, Princeton and triangle.

The blue words in today’s Connections

The theme is triple-A baseball teams. The four answers are Aces, Jumbo Shrimp, Sounds and Storm Chasers.

The purple words in today’s Connections

The theme is ends with a basketball stat. The four answers are afoul, bassist, counterpoint and sunblock.

Technologies

Amazon’s Delivery Drivers Will Soon Wear AI Smart Glasses to Work

The goal is to streamline the delivery process while keeping drivers safe.

Amazon announced on Wednesday that it is developing new AI-powered smart glasses to simplify the delivery experience for its drivers. CNET smart glasses expert Scott Stein mentioned this wearable rollout last month, and now the plan is in its final testing stages.

The goal is to simplify package delivery by reducing the need for drivers to look at their phones, the label on the package they’re delivering and their surroundings to find the correct address.

Don’t miss any of our unbiased tech content and lab-based reviews. Add CNET as a preferred Google source.

A heads-up display will activate as soon as the driver parks, pointing out potential hazards and tasks that must be completed. From there, drivers can locate and scan packages, follow turn-by-turn directions and snap a photograph to prove delivery completion without needing to take out their phone.

The company is testing the glasses in select North American markets.

Watch: See our Instagram post with a video showing the glasses

A representative for Amazon didn’t immediately respond to a request for comment.

To fight battery drain, the glasses pair with a controller attached to the employee’s delivery vest, allowing them to replace depleted batteries and access operational controls. The glasses will support an employee’s eyeglass prescription. An emergency button will be within reach to ensure the driver’s safety.

Amazon is already planning future versions of the glasses, which will feature «real-time defect detection,» notifying the driver if a package was delivered to the incorrect address. They plan to add features to the glasses to detect if pets are in the yard and adjust to low light.