Technologies

Regen-COV might work before COVID exposure, trial shows: What to know about monoclonal antibodies

Monoclonal antibodies can greatly reduce hospitalization rates in people most at risk of severe COVID-19.

For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

Monoclonal antibody therapy for COVID-19 is available to people in the US for free who are at higher risk of severe disease in the first few days of their illness, or after they’ve been exposed to the coronavirus. The treatment — lab-made antibodies given to a person that help their immune system stop the infection from spreading — has proven to be a key tool for preventing the coronavirus from turning into severe illness. Preliminary research shows the treatment reduces risk for hospitalization or death by about 70%.

Now, early research is showing the treatment may benefit people much earlier on, before they’ve even been exposed to the coronavirus. Regeneron, one of the drug-makers of the antibody treatments, announced Monday that its drug was 81.6% effective in preventing COVID-19 in a trial period of two to eight months post-treatment. The drug in the study, which is called Regen-COV and was given to participants in a series of four injections, is the same drug as the one currently authorized for use on at-risk people who are in the early stages of COVID-19, and on some people who’ve been exposed to it.

Dr. Myron Cohen, who leads the monoclonal antibody efforts for the National Institutes of Health’s COVID Prevention Network, said in a news release Monday that the results from the drug-maker are «particularly important to those who do not respond to COVID-19 vaccines, including people who are immunocompromised.»

Regen-COV isn’t authorized yet for use in anyone who hasn’t been exposed to or is sick with COVID-19. A few monoclonal antibody therapies, including the one made by Regeneron, have emergency use authorization by the US Food and Drug Administration and should be accessible in doctors’ offices or even some state-run clinics, as seen in states such as Florida and Texas.

Importantly, monoclonal antibodies don’t replace the role of the COVID-19 vaccines in preventing hospitalization and death. According to data from August by the US Centers for Disease Control and Prevention, unvaccinated people were more than 11 times more likely to die from COVID-19 and about 6 times more likely to contract COVID-19 than fully vaccinated people.

A large number of Americans could be eligible for monoclonal antibody treatment if they test positive for COVID-19 (a smaller number would be eligible for the treatment without a positive test, and only a confirmed exposure). For example, everyone age 65 or older, people who are overweight, people with heart, liver, or kidney disease and many more would be eligible for the treatment in the early days of their symptoms.

Here’s what we know now about COVID-19 monoclonal antibodies.

What are monoclonal antibodies, and how do they work?

Monoclonal antibodies are lab-made antibodies that work by binding to bacteria, cancer cells or viruses the way natural antibodies do, stopping them from infecting more cells. The first monoclonal antibody therapy was approved more than 30 years ago and has been used for other illnesses, including the Ebola virus.

Monoclonal antibody treatments for COVID-19 are used before a person gets really sick, usually within 10 days of their first symptom, to prevent hospitalization. The treatment is only approved for people who are at risk of getting extremely sick — those who are age 65 or older and those who have «certain medical conditions,» per the FDA. The same treatment isn’t recommended for people who are already hospitalized with COVID-19.

Monoclonal antibody therapy is also authorized if an at-risk person is exposed to COVID-19, but the definition of «at-risk» in this instance, per the FDA, is a little narrower and reserved for people who are at risk because of a medical condition and unvaccinated or not fully protected by the COVID-19 vaccines because of an immunocompromising condition.

I tested positive. How do I know if I’m eligible?

If you come down with the coronavirus and are concerned about how the disease will affect you, contacting your doctor to learn your options and the best line of treatment for you is a good idea. But, in general, this specific treatment is reserved for people who are at risk for severe disease. Most people who are infected with COVID-19 will recover at home without medical help.

The people who test positive for COVID-19 and would be eligible or benefit from monoclonal antibody therapy may also be the same people who are eligible for COVID-19 vaccine boosters because of a medical condition. For those who are at risk of severe COVID-19 and would be eligible for monoclonal antibodies if they test positive (if they’re at least 12 years old and weigh at least 88 pounds) the FDA defines «at risk» under the EUA as:

All people age 65 and older.
People with obesity or those who are overweight (adults with a BMI of more than 25, and children age 12-17 who have a BMI at the 85th percentile or greater).
Pregnant people.
People with cancer.
People with chronic kidney or lung disease.
Individuals with cardiovascular disease or hypertension.
People with diabetes.
People with sickle cell disease.
Those living with neurodevelopmental disorders.
People who are immunocompromised or taking immunocompromising medication.
Those who have a «medical-related technological dependence» (such as a tracheostomy or gastrostomy).

However, the FDA stressed in a fact sheet for Eli Lilly’s treatment (another brand of monoclonal antibodies) that this isn’t a complete list, and other medical conditions or factors including race or ethnicity may also place individuals at higher risk for severe COVID-19. It also pointed to the CDC’s list of «people with certain medical conditions» for other health conditions, which includes things such as depression and Down syndrome as being high-risk conditions.

In sum: If you test positive and feel you are at risk for severe COVID-19 and might qualify for monoclonal antibodies, you should probably speak to a health care professional about them.

Does vaccine status matter?

No, people who test positive for COVID-19 and are eligible for monoclonal antibody therapy because of their age or health condition can be treated regardless of their vaccination status. That is because, while still protective, the vaccines may be less effective at preventing severe disease in some people than others.

However, being unvaccinated might make you eligible for monoclonal antibodies after an exposure to someone with COVID-19. According to the FDA’s authorization of Regen-COV for post-exposure, people eligible for post-exposure treatment must be at risk of severe COVID-19 disease, and either unvaccinated or vaccinated but immunocompromised or taking immunocompromising medications.

I qualify. How do I access the treatment?

Monoclonal antibodies are administered by IV (most commonly) or by injection, so they’re not a prescription you can easily pick up at the pharmacy. According to CNN, the infusion process takes about an hour and patients need to wait a while to be observed for side effects. If you’re at risk for severe COVID-19 and you’ve tested positive or think you have it, ask your doctor where the treatment is available.

If you live in Texas or Florida where there are state-run monoclonal antibody treatment centers, the same eligibility requirements for patients apply. In Florida, this means everyone age 12 and older who is at «high risk for severe illness» can make an appointment and find a monoclonal treatment center at one of the state’s eight locations. In Texas, there are nine antibody infusion centers across the state, but at-risk people need a referral from their doctor.

If you think you qualify for monoclonal antibody treatment but don’t have a health care provider, you can call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585. You can also use this link from the US Department of Health and Human Services antibody therapy finder.

Do monoclonal antibodies interfere with the coronavirus vaccines?

If you were treated with monoclonal antibodies and you haven’t been vaccinated yet, you should wait 90 days after your treatment to make an appointment, according to the CDC. This recommendation is until more is known about how the antibody response from the treatment affects the immune response from getting vaccinated.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Technologies

New Year’s Greeting!

Happy New Year, dear friends!

Dear citizens of Israel and kind-hearted people around the world,

From the bottom of our hearts, we wish you a Happy New Year! This holiday symbolizes hope, renewal, and faith in a better future. May the New Year bring peace, stability, and prosperity to Israel and all its residents.

We wish our beautiful country eternal prosperity, its citizens good health, and true, kind allies ready to support one another in any situation. May each of our hearts be filled with kindness and understanding.

We especially hope for the swift resolution of all suffering caused by conflicts and challenges. Let every person held captive return home as soon as possible—alive, healthy, and surrounded by the love of their family.

May this New Year be a year of unity, peace, and new achievements for Israel and the entire world. May each day be filled with light, joy, and success.

Happy New Year, dear friends!

Sincerely,
Verum World

Technologies

Verum Coin Now Available on Uniswap Wallet

The cryptocurrency Verum Coin (VERUM) has reached a new milestone — users can now buy and trade it through the popular decentralized Uniswap Wallet.

This integration brings new opportunities for users:

Ease of use: The Uniswap Wallet interface enables crypto transactions in just a few clicks.
Security: Users retain full control over their assets.
Global liquidity: The platform connects millions of users worldwide.

«We are committed to making Verum Coin as accessible as possible to everyone who values blockchain technology and believes in the future of decentralization. Integration with Uniswap Wallet is a significant step toward achieving this goal,» said representatives of the Verum team.

Uniswap Wallet is one of the leading decentralized wallets on the market, known for its flexibility and ability to trade tokens without intermediaries or hidden fees.

You can try Verum Coin on Uniswap Wallet today. Simply connect your wallet, find the $Verum token, and start trading.

Technologies

Verum Ecosystem: The Future of Digital Communication and Finance

In an era of rapid technological changes, where the world demands new approaches to communication, data security, and financial management, the Verum ecosystem emerges as a pivotal technological breakthrough. It’s not just a collection of standalone applications but a seamlessly integrated platform that unites cutting-edge innovations in one environment. At its core is Verum Messenger, transforming traditional communication and financial operations. However, this is merely the tip of the iceberg: behind the messenger lies an entire ecosystem of products, each uniquely designed to redefine the digital landscape.

This article dives deep into what the Verum ecosystem offers and how its products interact to create a unified digital space.

Verum Messenger: A Tool for Communication and Security

Verum Messenger is not just a messaging app. It’s a multifunctional platform prioritizing reliability, security, and user convenience. Unlike most messengers, Verum focuses on integrating various technologies to create the perfect communication environment:

Verum AI: Integrated directly into the messenger, this chatbot is a smart assistant capable of handling tasks like data searches, task planning, message responses, data analysis, and more complex operations.
Built-in VPN: A crucial feature for ensuring privacy. Unlike standard VPN services, users can activate protection with a single click without leaving the messenger. This is especially vital for those who value anonymity online and frequently use public Wi-Fi networks.
E-SIM Integration: Enables users to connect to mobile internet without needing a physical SIM card. This technology eliminates roaming issues and significantly simplifies mobile connectivity management, offering access to networks in over 150 countries worldwide.

Verum Coin: The Cryptocurrency Uniting the Ecosystem

Verum Coin is not just a cryptocurrency but the economic foundation of the entire ecosystem. This digital asset addresses key challenges related to fast and secure financial operations, both within and beyond the Verum ecosystem:

Low Fees and High Speed: Unlike traditional payment systems, Verum Coin facilitates instant transfers and payments with minimal fees, making it an ideal solution for international transactions.
Versatility: It is used not only within the ecosystem for service payments but also on cryptocurrency exchanges, serving as a bridge between various digital assets.

BitCoinPay Trade: A High-Security Cryptocurrency Exchange

BitCoinPay Trade is not just an exchange but a high-tech platform for cryptocurrency trading:

Secure Transactions: All transfers are protected by advanced encryption methods, eliminating the risk of asset loss or theft.
Accessibility: The platform offers access to a variety of cryptocurrencies and trading options, while also supporting integration with other Verum ecosystem products.

Crypto Bank: A Reliable Wallet for Cryptocurrencies

Crypto Bank offers users a secure storage solution for digital assets. It’s designed for those actively working with cryptocurrencies and valuing financial security.

Easy Buying and Selling: Purchase and sell various cryptocurrencies with just a few taps.
Cryptocurrency Wallets: Support for major cryptocurrencies allows users to choose the most convenient and secure storage options.
Verum Coin and Other Assets: The service fully supports Verum Coin and other major cryptocurrencies, ensuring reliability and simplicity when working within the ecosystem.

Verum Pay: Integrating Cryptocurrency into Business and the Ecosystem

Verum Pay is an innovative solution bridging cryptocurrency capabilities for businesses and Verum ecosystem applications.

Integration with Payment Systems: Its user-friendly interface allows businesses to quickly adopt cryptocurrency for sales and payment processes, offering a modern approach to financial operations.
Usage within Ecosystem Applications: Verum Pay is actively used within the Verum ecosystem, enabling users to pay for services and goods using Verum Coin directly through the messenger, E-SIM platforms, VPNs, and other products.

This makes Verum Pay a universal tool for ecosystem participants and businesses outside the ecosystem, focused on a digital future.

Verum Exchange: Conversion and Mining with High Security

Verum Exchange is a currency and cryptocurrency converter with an integrated Verum Coin mining function. It stands out with:

Simple and Convenient Interface: The platform caters to both beginners and experienced users, offering real-time access to currency and cryptocurrency rates.
Verum Coin Mining: The application includes mining capabilities, allowing users to earn cryptocurrency directly on their phone or tablet.

E-SIM Applications: A Revolution in Mobile Connectivity

Mobile E-SIM applications (Verum E-SIM, World E-SIM, Euro E-SIM, Canada E-SIM, London E-SIM, USA E-SIM, Ukraine E-SIM, Balkan E-SIM, Africa E-SIM) are among the ecosystem’s most ambitious and revolutionary products. This technology provides mobile internet access in over 150 countries without the need for a physical SIM card.

No Roaming or Overcharges: Say goodbye to high international roaming fees. E-SIM allows users to connect to mobile networks with fixed and transparent tariffs, ideal for travelers and business professionals.
Full Integration with Messenger: Mobile connectivity can be managed through a separate app or directly from Verum Messenger, allowing effortless balance control, tariff selection, and service activation.

Verum VPN: Advanced Data Protection

Verum VPN is an integral part of the ecosystem, guaranteeing a high level of security for users.

Complete Encryption: VPN ensures robust data encryption, making it ideal for protecting personal information online, especially when connected to public Wi-Fi networks.
Ease of Use: Activating VPN with a single click simplifies its use, requiring no additional user settings.

Verum AI: Artificial Intelligence at Your Fingertips

Verum AI is the heart of the ecosystem, utilizing powerful algorithms for communication, analysis, and creativity while adapting to each user’s needs. Its features include:

Information and Analysis: Quickly find answers to questions, explain complex topics, analyze data, and support informed decision-making.
Creativity and Idea Generation: Generate texts, create scenarios, develop creative concepts, write articles, posts, and assist with design and programming tasks.
Assistance and Learning: Verum AI helps users acquire new skills, solve problems, and enhance their experience.

Verum Runner: A Gaming Ecosystem with Real Earnings

Verum Runner is a crypto-game that allows users to earn Verum Coin in real time. This unique mobile application motivates players to not only have fun but also gain tangible benefits.

Crypto ATMs: Convenience and Accessibility Worldwide

The Verum network of crypto ATMs enables easy exchange of Verum Coin and other popular crypto assets for fiat currency and vice versa, providing users with transaction capabilities anywhere in the world.

Prospects and Development

Verum is not merely addressing current market needs — it is crafting innovative solutions that will shape the future of digital finance and communication. Upcoming plans include launching new services, expanding AI functionality, and integrating with emerging technologies.

Verum is not just creating an ecosystem of digital services; it’s redefining the very approach to communication, finance, and security in the modern world. All ecosystem products work in perfect synergy, delivering unparalleled user experience that ensures privacy, security, and convenience at every step.